Ms. Alina Sharova Profile

Alina Sharova

Msc Student

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Proceedings Article | 28 May 2018 Paper

Optical fiber neurosystem for deep-lying brain tumors phototheranostics

Alina Sharova, Yuliya Maklygina , Igor Romanishkin , Gaukhar Yusubalieva, Anastasia Ryabova, Vladimir Сhekhonin, Victor Loschenov

Proceedings Volume 10695, 106950O (2018) https://doi.org/10.1117/12.2312027

KEYWORDS: Brain, Tumors, Optical fibers, Fiber optics, Tissues, Diagnostics, Photodynamic therapy, Luminescence, Tissue optics

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Current paper presents the results of the optical neurosystem research for intracranial implantation targeted on phototheranostics of deep-lying brain tumors. Brain tumors treatment is a complicated multistage process, and currently there is a need for the user-friendly fiber optic toolkit that could allow carrying out multiple diagnostics and therapy of such neoplasms type without additional surgical intervention. The optical neurosystem developed in the framework of this study is based on the scaffold with the internal optical fiber structure placed into the tumor bed and designed for diagnostic and therapeutic laser radiation delivery. Such neurosystem, along with specific photosensitive agent application will provide malignant cells diagnostics by the fluorescent signal and permanent monitoring of processes occurring in the probed area by means of fiber optic probe with emitting and receiving fibers connected with laser source and spectrometer, respectively. The created neurosystem could be used to direct the growth of randomly proliferated deep lying brain tumor cells along the scaffold fibers towards the extracranial surface where malignant cells could be registered, identified and therapeutically affected by photodynamic action. A set of preliminary experiments devoted to spectral-optical evaluation of brain tissue properties was performed. The research of the scaffold and its inner fiber optical structure was carried out on the model samples of brain tissue phantom and in vitro on C6 glioblastoma cell line. Obtained results are being discussed.

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