Dr. Anton Liopo Profile

Dr. Anton Liopo

Lead Scientist at TomoWave Labs Inc

SPIE Involvement:

Author

Publications (18)

SPIE Journal Paper | 8 November 2016 Open Access

Imaging technique for real-time temperature monitoring during cryotherapy of lesions

Elena Petrova, Anton Liopo, Vyacheslav Nadvoretskiy, Sergey Ermilov

JBO, Vol. 21, Issue 11, 116007, (November 2016) https://doi.org/10.1117/12.10.1117/1.JBO.21.11.116007

KEYWORDS: Blood, Temperature metrology, Tissues, Thermometry, Calibration, Tissue optics, Real time imaging, Scattering, Statistical analysis, Thermography

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SPIE Journal Paper | 27 May 2016 Open Access

Optical clearing of skin enhanced with hyaluronic acid for increased contrast of optoacoustic imaging

Anton Liopo, Richard Su, Dmitri Tsyboulski, Alexander Oraevsky

JBO, Vol. 21, Issue 08, 081208, (May 2016) https://doi.org/10.1117/12.10.1117/1.JBO.21.8.081208

KEYWORDS: Skin, Tissue optics, Optical clearing, Imaging systems, Biomedical optics, Tissues, Nickel, Water, Polymers, Image segmentation

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Proceedings Article | 18 March 2016 Presentation + Paper

Small animal optoacoustic tomography system for molecular imaging of contrast agents

Richard Su, Anton Liopo, Sergey Ermilov, Alexander Oraevsky

Proceedings Volume 9708, 97081S (2016) https://doi.org/10.1117/12.2217635

KEYWORDS: Molecular imaging, Tomography, Imaging systems, Signal to noise ratio, Pre-clinical research, Indocyanine green, In vivo imaging, Spatial resolution, Preclinical imaging, Animal model studies, Absorption, Tumors, Blood, Image segmentation, Protactinium, Neodymium

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Proceedings Article | 11 March 2015 Paper

Universal temperature-dependent normalized optoacoustic response of blood

Elena Petrova, Anton Liopo, Alexander Oraevsky, Sergey Ermilov

Proceedings Volume 9323, 93231Y (2015) https://doi.org/10.1117/12.2083594

KEYWORDS: Blood, Temperature metrology, Tissues, Absorbance, Calibration, Tissue optics, Ultrasonography, Plasma, Light scattering, Liquids

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Proceedings Article | 3 March 2014 Paper

Controlled bacteria-gold nanorod interactions for enhancement of optoacoustic contrast

Anton Liopo, Paul Derry, Boris Ermolinsky, Richard Su, André Conjusteau, Sergey Ermilov, Eugene Zubarev, Alexander Oraevsky

Proceedings Volume 8943, 894368 (2014) https://doi.org/10.1117/12.2044628

KEYWORDS: Bacteria, Gold, Plasmons, Imaging systems, Absorbance, Scanning electron microscopy, Absorption, Optical properties, Calibration, Nanorods

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Proceedings Article | 4 March 2013 Paper

Towards non-invasive in vivo measurements of nanoparticle concentrations using 3D optoacoustic tomography

Dmitri Tsyboulski, Anton Liopo, Richard Su, Sergei Ermilov, Sergei Bachilo, R. Bruce Weisman, Alexander Oraevsky

Proceedings Volume 8581, 85814V (2013) https://doi.org/10.1117/12.2008897

KEYWORDS: Absorption, Nanoparticles, Spleen, Liver, Kidney, Luminescence, In vivo imaging, Tomography, Tissue optics, Tissues

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SPIE Journal Paper | 15 June 2012 Open Access

Three-dimensional optoacoustic imaging as a new noninvasive technique to study long-term biodistribution of optical contrast agents in small animal models

Richard Su, Sergey Ermilov, Anton Liopo, Alexander Oraevsky

JBO, Vol. 17, Issue 10, 101506, (June 2012) https://doi.org/10.1117/12.10.1117/1.JBO.17.10.101506

KEYWORDS: Blood, 3D image processing, Gold, Nanoparticles, Video, Kidney, Image segmentation, Absorption, 3D modeling, Biomedical optics

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Proceedings Article | 23 February 2012 Paper

PEG-coated gold nanorod monoclonal antibody conjugates in preclinical research with optoacoustic tomography, photothermal therapy, and sensing

Anton Liopo, André Conjusteau, Alexander Oraevsky

Proceedings Volume 8223, 822344 (2012) https://doi.org/10.1117/12.910838

KEYWORDS: Gold, Monoclonal antibodies, Tumors, Leukemia, Liver, Receptors, Pre-clinical research, Tomography, Nanoparticles, Nanorods

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Proceedings Article | 23 February 2012 Paper

Optoacoustic 3D visualization of changes in physiological properties of mouse tissues from live to postmortem

Richard Su, Sergey Ermiliov, Anton Liopo, Alexander Oraevsky

Proceedings Volume 8223, 82230K (2012) https://doi.org/10.1117/12.910975

KEYWORDS: Blood, Tissues, Neodymium, Tomography, Organisms, Kidney, 3D visualizations, Hypoxia, Opacity, Visualization

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Proceedings Article | 15 June 2011 Paper

Optoacoustic tomography in preclinical research: in vivo distribution of highly purified PEG-coated gold nanorods

Richard Su, Anton Liopo, Hans-Peter Brecht, Sergey Ermilov, Kirill Larin, Alexander Oraevsky

Proceedings Volume 8089, 808902 (2011) https://doi.org/10.1117/12.889757

KEYWORDS: Liver, Gold, Absorption, Toxicity, Tomography, In vivo imaging, 3D image processing, Tissues, Kidney, Nanorods

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Proceedings Article | 11 April 2011 Paper

Optoacoustic imaging system with improved collection efficiency

Dmitri Tsyboulski, André Conjusteau, Sergey Ermilov, Hans-Peter Brecht, Anton Liopo, Richard Su, Vyacheslav Nadvoretsky, Alexander Oraevsky

Proceedings Volume 7899, 78991D (2011) https://doi.org/10.1117/12.877723

KEYWORDS: Transducers, Ultrasonography, Wavefronts, Microscopy, Reflectors, Mirrors, Acoustics, Signal attenuation, Imaging systems, Spherical lenses

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Proceedings Article | 28 February 2011 Paper

Gold nanorod distribution in mouse tissues after intravenous injection monitored with optoacoustic tomography

Richard Su, Anton Liopo, Hans-Peter Brecht, Sergey Ermilov, Alexander Oraevsky

Proceedings Volume 7899, 78994B (2011) https://doi.org/10.1117/12.878794

KEYWORDS: Liver, Kidney, Gold, Spleen, Tissues, Nanoparticles, Tomography, In vivo imaging, Silver, Nanorods

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Proceedings Article | 28 February 2011 Paper

Optoacoustic sensor for nanoparticle linked immunosorbent assay (NanoLISA)

André Conjusteau, Anton Liopo, Dmitri Tsyboulski, Sergey Ermilov, William Elliott, Norman Barsalou, Saher Maswadi, Randolph Glickman, Alexander Oraevsky

Proceedings Volume 7899, 789910 (2011) https://doi.org/10.1117/12.879401

KEYWORDS: Gold, Sensors, Nanoparticles, Biosensors, Target detection, Ferroelectric polymers, Pulsed laser operation, Acoustics, Signal to noise ratio, Nanorods

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Proceedings Article | 28 February 2011 Paper

Photothermal therapy of acute leukemia cells in the near-infrared region using gold nanorods CD-33 conjugates

Anton Liopo, André Conjusteau, Marina Konopleva, Michael Andreeff, Alexander Oraevsky

Proceedings Volume 7897, 789710 (2011) https://doi.org/10.1117/12.878802

KEYWORDS: Leukemia, Gold, Proteins, Particles, Cell death, Plasmons, Laser therapeutics, Laser applications, Nanoparticles, Nanorods

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Proceedings Article | 25 February 2009 Paper

Optoacoustic 3D whole-body tomography: experiments in nude mice

Hans-Peter Brecht, Richard Su, Matt Fronheiser, Sergey Ermilov, André Conjusteau, Anton Liopo, Massoud Motamedi, Alexander Oraevsky

Proceedings Volume 7177, 71770E (2009) https://doi.org/10.1117/12.812319

KEYWORDS: Blood vessels, Linear filtering, Wavelets, Tomography, Electronic filtering, Transducers, Imaging systems, Tissue optics, 3D image processing, Alexandrite lasers

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Proceedings Article | 28 February 2008 Paper

Optoacoustic system for 3D functional and molecular imaging in nude mice

Matthew Fronheiser, Alan Stein, Don Herzog, Scott Thompson, Anton Liopo, Mohammad Eghtedari, Massoud Motamedi, Sergey Ermilov, Andre Conjusteau, Reda Gharieb, Ron Lacewell, Tom Miller, Ketan Mehta, Alexander Oraevsky

Proceedings Volume 6856, 68560R (2008) https://doi.org/10.1117/12.770461

KEYWORDS: Imaging systems, Tissues, Tumors, Sensors, Gold, Molecular imaging, Image resolution, 3D image processing, Tissue optics, Nanorods

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A three-dimensional laser optoacoustic imaging system was developed, which combines the advantages of optical spectroscopy and high resolution ultrasonic detection, to produce high contrast maps of optical absorbance in tissues. This system was tested in a nude mouse model of breast cancer and produced tissue images of tumors and vasculature. The imaging can utilize either optical properties of hemoglobin and oxyhemoglobin, which are the main endogenous tissue chromophores in the red and near-infrared spectral ranges, or exogenous contrast agent based on gold nanorods. Visualization of tissue molecules targeted by the contrast agent provides molecular information. Visulization of blood at multiple colors of light provides functional information on blood concentration and oxygen saturation. Optoacoustic imaging, using two or more laser illumination wavelengths, permits an assessment of the angiogenesis-related microvasculature, and thereby, an evaluation of the tumor stage and its metastatic potential. The optoacoustic imaging system was also used to generate molecular images of the malignancy-related receptors induced by the xenografts of BT474 mammary adenocarcinoma cells in nude mice. The development of the latter images was facilitated by the use of an optoacoustic contrast agent that utilizes gold nanorods conjugated to monoclonal antibody raised against HER2/neu antigens. These nanorods possess a very strong optical absorption peak that can be tuned in the near-infrared by changing their aspect ratio. The effective conversion of the optical energy into heat by the gold nanorods, followed by the thermal expansion of the surrounding water, makes these nanoparticles an effective optoacoustic contrast agent. Optical scattering methods and x-ray tomography may also benefit from the application of this contrast agent. Administration of the gold nanorod bioconjugates to mice resulted in an enhanced contrast of breast tumors relative the background of normal tissues in the nude mouse model. The combination of this novel contrast agent and optoacoustic imaging has the potential to become a useful imaging modality, for preclinical research in murine models of cancer and other human diseases.