Due to the high manufacturing cost of Nickel based alloy compressor blisks, aero engine repairing process research has important engineering significance and economic value. Inconel718 Ni-based superalloy has the advantages of irradiation, corrosion resistance and excellent mechanical and processing properties. In this paper, a production process for the laser additive and subtractive hybrid manufacturing technologies was presented to repair a microcrack of Inconel 718. The whole repairing process includes four steps. Firstly, a pulsed laser was used to clean and etch the crack through materials subtractive. Secondly, a high-power continuous wave laser was used to additive material in the crack by laser deposition. Thirdly, a pulsed laser was applied to remove the excess repair material. Finally, a fiber laser was used to polish surface. The results showed that defect-free repair samples can be obtained with proper processing parameters. Metallurgical bonding could be achieved between the melting Inconel718 powder and the substrate under the action of a high-energy laser beam. The columnar dendrite and inter-dendritic structure in the repair zone are epitaxially grown along the deposition direction. The microstructure in the repair zone was fine and uniform due to the high gradient, high-speed solidification characteristics of the laser rapid fusion. The micro-hardness of the repaired tissue reduced to about 87% of the matrix and there was no new phase produced in the repair zone.