Prof. Benjamin L. Miller Profile

Prof. Benjamin L. Miller

Professor of Dermatology at Univ of Rochester Medical Ctr

SPIE Involvement:

Conference Chair | Editor | Author | Special Event Speaker

Publications (35)

Proceedings Article | 17 March 2023 Presentation

Real-time monitoring of tissue chips via integrated photonic sensors (Conference Presentation)

Benjamin Miller, John Cognetti, Maya Moen

Proceedings Volume PC12397, PC1239701 (2023) https://doi.org/10.1117/12.2657458

KEYWORDS: Sensors, Tissue optics, Microfluidics, Integrated photonics, Tissues, Photodetectors, Veins, Systems modeling, Silicon, Resonators

Read Abstract +

Proceedings Article | 17 March 2023 Presentation

Monitoring anti-viral antibody production throughout vaccination and breakthrough Covid-19 infection via arrayed imaging reflectometry (Conference Presentation)

Gabrielle Kosoy, Alanna Klose, Benjamin Miller

Proceedings Volume PC12397, PC1239709 (2023) https://doi.org/10.1117/12.2665014

Read Abstract +

The world is adopting new vaccination strategies to SARS-CoV-2. The ability of a vaccine to provide immunity can be impacted negatively by mutations in the circulating virus or by non-neutralizing cross-reactive from previous coronavirus infections. It is important to monitor immune response and identify cross-reactivity for antigen mutations and common cold coronavirus strains. To study antibody-antigen interactions in a high throughput and label-free manner we use Arrayed Imaging Reflectometry (AIR). AIR provides information about protein binding for an array with a single CCD image by measuring the change in reflectivity of a silicon/silicon dioxide/protein surface (AIR chip). In this talk we discuss our study in which we use a 37-plex AIR array including Influenza and Coronavirus antigens to study changes in the human immune response to vaccination against SARS-CoV-2. Structural changes to viral surface antigens in Coronaviruses and Influenza viruses can change the immune response to those viruses. This talk will discuss the effect of amino acid mutations in SARS-CoV-2 (SARS2) and related coronaviruses, and structural differences in Influenza virus antigens in terms of their presentation: either recombinantly expressed protein or whole virus particles. We hypothesized that the previously mentioned structural differences would lead to changes in amount of antibody binding and cross-reactivity. We have found that in response to SARS2 vaccination, human subjects have significant increases in antibodies against common cold coronavirus 229E, and that those antibodies strongly correlate with increases in antibodies against SARS2 surface antigen proteins. We also found that increase in 229E antibody binding was more strongly correlated with the S2 subunit of the spike protein of SARS2 than with the S1 subunit. We have also found that there is significantly more antibody binding to the S1 D614G mutant protein than to the wild-type protein, though the antibody binding against the two proteins is strongly correlated. In the future, this technology can help understand antibody response as well as antigen cross-reactivity in response to vaccination and infection.

Proceedings Article | 30 May 2022 Presentation + Paper

Waveguide Enhanced Raman Spectroscopy (WERS) for biomarker detection and identification

Nathan Tyndall, Dmitry Kozak, Marcel Pruessner, Todd Stievater, Benjamin Miller, P. Y. Wang, J. Butt

Proceedings Volume 12116, 121160F (2022) https://doi.org/10.1117/12.2623361

KEYWORDS: Waveguides, Raman spectroscopy, Urea, Glucose, Water, Photonic integrated circuits, Optical filters, Cladding

Read Abstract +

Proceedings Article | 30 May 2022 Presentation + Paper

New polymer sorbents for waveguide-enhanced Raman spectroscopy (WERS) and refractive index-based photonic sensing

Ethan Luta, Brittany Watterson, Matthew Yates, Benjamin Miller

Proceedings Volume 12116, 121160E (2022) https://doi.org/10.1117/12.2619383

KEYWORDS: Silicon, Polymers, Waveguides, Sodium, Resonators, Raman spectroscopy, Photodetectors, Polymer multimode waveguides, Photorefractive polymers, Chemical weapons

Read Abstract +

Proceedings Article | 5 March 2022 Presentation + Paper

Waveguide-enhanced Raman spectroscopy for field detection of threat materials

Erik Emmons, Phillip Wilcox, Erik Roese, Ashish Tripathi, Jason Guicheteau, Kevin Hung, Benjamin Miller, Ethan Luta, Matthew Yates, Nathan Tyndall, Todd Stievater

Proceedings Volume 12004, 120040L (2022) https://doi.org/10.1117/12.2610654

KEYWORDS: Raman spectroscopy, Waveguides, Polymers, Spectrometers, Silicon, Sensors, Photonic integrated circuits, Microscopy, Imaging spectroscopy, Polymer multimode waveguides

Read Abstract +

Proceedings Article | 2 March 2022 Presentation + Paper

Strategies for the development of photonic sensors for COVID-19

Benjamin Miller, Alanna Klose, Michael Bryan, John Cognetti, Daniel Steiner, Natalya Tokranova, Brian Piorek, Nicholas Judy, Minhaz Abedin, Ethan Young, Carl Meinhart, Raymond Jakubowicz, Harold Warren, Nathaniel Cady

Proceedings Volume 11951, 1195104 (2022) https://doi.org/10.1117/12.2616682

KEYWORDS: Sensors, Photodetectors, Blood, Microfluidics, Reflectometry, Molecules, Imaging arrays, Diagnostics, Control systems, Viruses

Read Abstract +

Proceedings Article | 12 April 2021 Presentation

Optical sensors for coronavirus antibodies: Analyzing the human response to COVID-19

Benjamin Miller, John Cognetti, Daniel Steiner, Michael Bryan, Alanna Klose, Ethan Luta, Joseph Bucukovski, Conor Shanahan, Minhaz Abedin, Natalya Tokranova, Ethan Young, Carl Meinhart, Jon Schmuke, Harold Warren, Raymond Jakubowicz, Nathaniel Cady

Proceedings Volume 11749, 117490F (2021) https://doi.org/10.1117/12.2586109

KEYWORDS: Optical sensors, Sensors, Pathogens, Viruses, Surveillance, Reflectometry, Photodetectors, Integrated photonics, Imaging arrays, Blood

Read Abstract +

Proceedings Article | 5 March 2021 Presentation

Analyzing the human response to COVID-19 with arrayed imaging reflectometry

Benjamin Miller

Proceedings Volume 11626, 1162607 (2021) https://doi.org/10.1117/12.2577253

KEYWORDS: Reflectometry, Imaging arrays, Pathogens, Viruses, Surveillance, Silicon, Monoclonal antibodies, Diagnostics, Control systems, Biology

Read Abstract +

Proceedings Article | 5 March 2021 Presentation

Welcome and Introduction to SPIE Conference 11662

Amos Danielli, Benjamin Miller, Sharon Weiss

Proceedings Volume 11662, 1166202 (2021) https://doi.org/10.1117/12.2595102

Read Abstract +

Proceedings Article | 5 March 2021 Presentation + Paper

Photonics-enabled lateral flow assay diagnostics

Daniel Steiner, Benjamin Miller

Proceedings Volume 11662, 116620F (2021) https://doi.org/10.1117/12.2582768

KEYWORDS: Sensors, Etching, Diagnostics, Silicon, Photodetectors, Waveguides, Interfaces, Refractive index, HF etching, Silica

Read Abstract +

Proceedings Article | 24 April 2020 Presentation + Paper

Backscatter WERS for trace chemical analyte detection using a handheld spectrometer

N. Tyndall, D. Kozak, M. Pruessner, R. A. McGill, C. Roberts, T. Stievater, B. Miller, E. Luta, M. Yates, E. Emmons, P. Wilcox, J. Guicheteau

Proceedings Volume 11416, 1141603 (2020) https://doi.org/10.1117/12.2559641

KEYWORDS: Waveguides, Spectroscopy, Optical filters, Backscatter, Raman spectroscopy, Chemical analysis, Biological research, Analytical research

Read Abstract +

Proceedings Article | 10 March 2020 Presentation

Silicon nitride ring resonator biosensors fabricated at AIM Photonics: detection of cytokines (Conference Presentation)

Benjamin Miller, Michael Bryan, John Cognetti, Daniel Steiner

Proceedings Volume 11258, 112580C (2020) https://doi.org/10.1117/12.2553072

Read Abstract +

Proceedings Article | 14 May 2019 Presentation

Waveguide-enhanced Raman spectroscopy for characterizing sorbent-analyte binding (Conference Presentation)

Todd Stievater, Nathan Tyndall, Dmitry Kozak, Marcel Pruessner, R. Andrew McGill, Courtney Roberts, Benjamin Miller, Ethan Luta, Matthew Yates

Proceedings Volume 11010, 110100C (2019) https://doi.org/10.1117/12.2521451

KEYWORDS: Raman spectroscopy, Waveguides, Polymers, Photonic integrated circuits, Nerve agents, Molecules

Read Abstract +

Proceedings Article | 4 March 2019 Presentation

Cost-effective optical biosensing using integrated photonics (Conference Presentation)

Daniel Steiner, Michael Bryan, Benjamin Miller

Proceedings Volume 10895, 108950S (2019) https://doi.org/10.1117/12.2509924

KEYWORDS: Integrated photonics, Integrated optics, Biosensing, Medicine, Photoresist materials, Silicon, Manufacturing, Resonators, Diagnostics, Point-of-care devices

Read Abstract +

Proceedings Article | 4 March 2019 Presentation

Development of silicon nitride photonic microring resonator arrays as a biosensing platform for multiplex detection of biologically relevant protein targets (Conference Presentation)

Michael Bryan, Benjamin Miller

Proceedings Volume 10895, 108950R (2019) https://doi.org/10.1117/12.2510453

KEYWORDS: Silicon photonics, Silicon, Resonators, Proteins, Biosensing, Photonic microstructures, Microrings, Target detection, Biosensors, Laser sources

Read Abstract +

Proceedings Article | 16 May 2018 Presentation + Paper

Design, manufacture, and testing of a silicon nitride ring resonator-based biosensing platform

Michael Bryan, Daniel Steiner, John Cognetti, Benjamin Miller

Proceedings Volume 10629, 106290Z (2018) https://doi.org/10.1117/12.2304526

KEYWORDS: Silicon, Resonators, Biosensing, Photonics, Refractive index, Manufacturing, Design for manufacturability, Biosensors, Optics manufacturing, Integrated photonics

Read Abstract +

Proceedings Article | 7 June 2017 Presentation

Single-particle detection of virus simulants under microfluidic flow with two-dimensional photonic crystals (Conference Presentation)

Benjamin Miller, James Baker, Rashmi Sriram

Proceedings Volume 10183, 101830H (2017) https://doi.org/10.1117/12.2265767

KEYWORDS: Microfluidics, Photonic crystals, Integrated photonics, Standards development, Sensors, CMOS sensors, Particles, Explosives, Weapons of mass destruction, Waveguides

Read Abstract +

Proceedings Article | 21 April 2017 Presentation

Towards a manufacturing ecosystem for integrated photonic sensors (Conference Presentation)

Benjamin Miller

Proceedings Volume 10081, 100810I (2017) https://doi.org/10.1117/12.2256252

KEYWORDS: Integrated photonics, Manufacturing, Sensors, Biosensing, Ecosystems, Optics manufacturing, Waveguides, Mach-Zehnder interferometers, Resonators, Photonic crystals

Read Abstract +

Proceedings Article | 12 May 2016 Paper

A label-free optical biosensor for serotyping "unknown" influenza viruses

Hanyuan Zhang, Carole Henry Dunand, Patrick Wilson, Benjamin Miller

Proceedings Volume 9824, 982405 (2016) https://doi.org/10.1117/12.2228245

KEYWORDS: Viruses, Antireflective coatings, Optical biosensors, Monoclonal antibodies, Imaging arrays, Reflectometry, Silicon, Molecules, Helium neon lasers, Control systems

Read Abstract +

Proceedings Article | 2 March 2015 Paper

Examining small molecule: HIV RNA interactions using arrayed imaging reflectometry

Wanaruk Chaimayo, Benjamin Miller

Proceedings Volume 9310, 931006 (2015) https://doi.org/10.1117/12.2085058

KEYWORDS: Molecules, Imaging arrays, Reflectometry, Silica, Silicon, Proteins, Reflectivity, Prisms, Target detection, Molecular interactions

Read Abstract +

Proceedings Article | 2 March 2015 Paper

A novel antibody immobilization strategy for optical biosensors

Mark Lifson, Jared Carter, Benjamin Miller

Proceedings Volume 9310, 931007 (2015) https://doi.org/10.1117/12.2083877

KEYWORDS: Particles, Nanoparticles, Silicon, Oxides, Proteins, Molecules, Polymers, Optical biosensors, Biosensors, Printing

Read Abstract +

Proceedings Article | 5 March 2013 Paper

Two dimensional photonic crystal biosensors as a platform for label-free sensing of biomolecules

Rashmi Sriram, James Baker, Philippe Fauchet, Benjamin Miller

Proceedings Volume 8570, 857007 (2013) https://doi.org/10.1117/12.2007285

KEYWORDS: Photonic crystals, Refractive index, Microfluidics, Waveguides, Particles, Biosensing, Crystals, Biosensors, Silicon, Molecules

Read Abstract +

Proceedings Article | 12 February 2011 Paper

Optical and fluidic design for guaranteed trapping and detection of particles in a silicon microfluidic and photonic crystal system

Adam Heiniger, Benjamin Miller, Philippe Fauchet

Proceedings Volume 7888, 78880L (2011) https://doi.org/10.1117/12.877569

KEYWORDS: Particles, Microfluidics, Resonators, Photonic crystals, Waveguides, Near field optics, Optical design, Photonic devices, Silicon, Finite element methods

Read Abstract +

Proceedings Article | 9 February 2011 Paper

Towards an optical concentrator for nanoparticles

James Baker, Rashmi Sriram, Philippe Fauchet, Benjamin Miller

Proceedings Volume 7888, 78880M (2011) https://doi.org/10.1117/12.877197

KEYWORDS: Waveguides, Microfluidics, Particles, Dielectrics, Nanoparticles, Sensors, Solar concentrators, Finite element methods, Photonic crystals, Channel projecting optics

Read Abstract +

Proceedings Article | 8 February 2011 Paper

Aqueous arrayed imaging reflectometry as a sensitive platform for real-time biomolecular interaction analysis

Amrita Yadav, Charles Mace, Benjamin Miller

Proceedings Volume 7888, 78880I (2011) https://doi.org/10.1117/12.876468

KEYWORDS: Reflectivity, Refractive index, Oxides, Sensors, Silicon, Water, Silica, Silicon films, Imaging arrays, Reflectometry

Read Abstract +

Proceedings Article | 17 February 2010 Paper

Microcavities in photonic crystal waveguides for biosensor applications

Sudeshna Pal, Elisa Guillermain, Rashmi Sriram, Benjamin Miller, Philippe Fauchet

Proceedings Volume 7553, 755304 (2010) https://doi.org/10.1117/12.848237

KEYWORDS: Waveguides, Biosensors, Optical microcavities, Photonic crystals, Molecules, Receptors, Silicon, Reactive ion etching, Target detection, Sensors

Read Abstract +

Proceedings Article | 17 February 2010 Paper

Multiplex detection of disease marker proteins with arrayed imaging reflectometry

Amrita Yadav, Rashmi Sriram, Benjamin Miller

Proceedings Volume 7553, 75530J (2010) https://doi.org/10.1117/12.847363

KEYWORDS: Proteins, Silicon, Reflectivity, Imaging arrays, Reflectometry, Antireflective coatings, Pathogens, Molecules, Oxides, Spectroscopic ellipsometry

Read Abstract +

Proceedings Article | 24 February 2009 Paper

Detection of methicillin-resistant Staphylococcus aureus (MRSA) using the NanoLantern Biosensor

Christopher Strohsahl, Benjamin Miller, Todd Krauss

Proceedings Volume 7167, 71670S (2009) https://doi.org/10.1117/12.808872

KEYWORDS: Resistance, Luminescence, Biosensors, Target detection, Image segmentation, Gold, Charge-coupled devices, Polymers, Distributed interactive simulations, Americium

Read Abstract +

Proceedings Article | 19 February 2009 Paper

Arrayed imaging reflectometry for inexpensive and label-free protein arrays

Christopher Striemer, Charles Mace, Jared Carter, Sourabh Mehta, Benjamin Miller

Proceedings Volume 7167, 71670G (2009) https://doi.org/10.1117/12.809943

KEYWORDS: Proteins, Reflectivity, Imaging arrays, Molecules, Pathogens, Silicon, Oxides, Reflectometry, Semiconducting wafers, Multiplexing

Read Abstract +

Proceedings Article | 19 February 2009 Paper

Tracking serum antibody response to viral antigens with arrayed imaging reflectometry

Charles Mace, Robert Rose, Benjamin Miller

Proceedings Volume 7167, 71670H (2009) https://doi.org/10.1117/12.811859

KEYWORDS: Proteins, Pathogens, Particles, Reflectometry, Imaging arrays, Silicon, Reflectivity, Oxides, Semiconducting wafers, Sensors

Read Abstract +

Proceedings Article | 19 February 2009 Paper

The role of alkanethiol spacers in a metal surface-based label-free DNA detection system

Hsin-I Peng, Zachary Nuffer, Benjamin Miller

Proceedings Volume 7167, 71670T (2009) https://doi.org/10.1117/12.808023

KEYWORDS: Molecules, Gold, Luminescence, Carbon, Metals, Pathogens, Biological detection systems, Charge-coupled devices, Sensors, Target detection

Read Abstract +

Proceedings Article | 13 September 2005 Paper

Silicon photonic bandgap biosensors

Huimin Ouyang, Mindy Lee, Benjamin Miller, Philippe Fauchet

Proceedings Volume 5926, 59260J (2005) https://doi.org/10.1117/12.621890

KEYWORDS: Optical microcavities, Silicon, Refractive index, Sensors, Mirrors, Reflectivity, Biosensing, Scanning electron microscopy, Biosensors, Coating

Read Abstract +

Proceedings Article | 1 June 2005 Paper

The effects of atmospheric compensation upon gaseous plume signatures

Benjamin Miller, David Messinger

Proceedings Volume 5806, (2005) https://doi.org/10.1117/12.603713

KEYWORDS: Atmospheric monitoring, Hyperspectral imaging, Atmospheric corrections, Absorption, 3D modeling, Atmospheric sciences, Image processing, Gases, Solid modeling, Algorithm development

Read Abstract +

Proceedings Article | 14 October 2004 Paper

Biosensing with one-dimensional photonic bandgap structure

Huimin Ouyang, Lisa DeLouise, Marc Christophersen, Benjamin Miller, Philippe Fauchet

Proceedings Volume 5511, (2004) https://doi.org/10.1117/12.561138

KEYWORDS: Optical microcavities, Sensors, Silicon, Reflectivity, Refractive index, Biosensors, Etching, Scanning electron microscopy, Mirrors, Latex

Read Abstract +

Proceedings Article | 1 July 2004 Paper

Trends in porous silicon biomedical devices: tuning microstructure and performance trade-offs in optical biosensors

Lisa DeLouise, Ben Miller

Proceedings Volume 5357, (2004) https://doi.org/10.1117/12.527578

KEYWORDS: Optical microcavities, Silicon, Mirrors, Reflection, Etching, Sensors, Luminescence, Biosensors, Absorbance, Oxidation

Read Abstract +

Showing 5 of 35 publications

Proceedings Volume Editor (16)

SPIE Conference Volume | 29 March 2024

Frontiers in Biological Detection: From Nanosensors to Systems XVI

SPIE Conference Volume | 2 May 2023

Frontiers in Biological Detection: From Nanosensors to Systems XV

SPIE Conference Volume | 14 April 2022

Frontiers in Biological Detection: From Nanosensors to Systems XIV

SPIE Conference Volume | 19 April 2021

Frontiers in Biological Detection: From Nanosensors to Systems XIII

SPIE Conference Volume | 6 April 2020

Frontiers in Biological Detection: From Nanosensors to Systems XII

Showing 5 of 16 publications

Conference Committee Involvement (17)

Frontiers in Biological Detection: From Nanosensors to Systems XVII

25 January 2025 | San Francisco, California, United States

Frontiers in Biological Detection: From Nanosensors to Systems XVI

28 January 2024 | San Francisco, California, United States

Frontiers in Biological Detection: From Nanosensors to Systems XV

29 January 2023 | San Francisco, California, United States

Frontiers in Biological Detection: From Nanosensors to Systems XIV

23 January 2022 | San Francisco, California, United States

Frontiers in Biological Detection: From Nanosensors to Systems XIII

6 March 2021 | Online Only, California, United States

Frontiers in Biological Detection: From Nanosensors to Systems XII

2 February 2020 | San Francisco, California, United States

Frontiers in Biological Detection: From Nanosensors to Systems XI

3 February 2019 | San Francisco, California, United States

Frontiers in Biological Detection: From Nanosensors to Systems X

28 January 2018 | San Francisco, California, United States