Dr. Bin Rao Profile

Dr. Bin Rao

Postdoc

SPIE Involvement:

Author

Publications (26)

SPIE Journal Paper | 10 September 2022 Open Access

Multiscale photoacoustic tomography of neural activities with GCaMP calcium indicators

Ruiying Zhang, Lei Li, Bin Rao, Haoyang Rong, Min-Yu Sun, Junjie Yao, Ruimin Chen, Qifa Zhou, Steven Mennerick, Baranidharan Raman, Lihong Wang

JBO, Vol. 27, Issue 09, 096004, (September 2022) https://doi.org/10.1117/12.10.1117/1.JBO.27.9.096004

KEYWORDS: Brain, Neuroimaging, Photoacoustic tomography, Calcium, Acquisition tracking and pointing, Neurons, Luminescence, Tissue optics, In vivo imaging, Signal detection

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Proceedings Article | 15 March 2018 Presentation

Endoscopic photoacoustic microscopy probe for human colorectal cancer imaging (Conference Presentation)

Xiandong Leng, Bin Rao, Quing Zhu

Proceedings Volume 10494, 1049419 (2018) https://doi.org/10.1117/12.2292016

KEYWORDS: Colorectal cancer, Colon, Endoscopy, Cancer, Photoacoustic microscopy, Photoacoustic spectroscopy, In vivo imaging, Ultrasonography, Imaging systems, Microscopes

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Proceedings Article | 1 March 2018 Paper

3D visualization of the ovarian tissue scattering coefficient with swept-source optical coherence tomography

Yifeng Zeng, Bin Rao, Sreyankar Nandy, Ian Hagemann, Cary Siegel, Matthew Powell, Quing Zhu

Proceedings Volume 10483, 1048338 (2018) https://doi.org/10.1117/12.2291718

KEYWORDS: Scattering, Tissues, Ovarian cancer, Visualization, Tissue optics, Optical coherence tomography, Ovary, Cancer, Collagen, 3D visualizations

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Proceedings Article | 27 April 2016 Presentation

In vivo photoacoustic neuronal imaging of odor-evoked calcium signals in the drosophila brain (Conference Presentation)

Ruiying Zhang, Bin Rao, Haoyang Rong, Baranidharan Raman, Lihong Wang

Proceedings Volume 9708, 97082V (2016) https://doi.org/10.1117/12.2235935

KEYWORDS: Brain, Neuroimaging, Photoacoustic spectroscopy, Photoacoustic imaging, In vivo imaging, Calcium, Tissue optics, Optical microscopy, Diffusion, Deep tissue imaging

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Proceedings Article | 27 April 2016 Presentation

Photoacoustic imaging of voltage signals (Conference Presentation)

Bin Rao, Ruiying Zhang, Lihong Wang

Proceedings Volume 9708, 97081U (2016) https://doi.org/10.1117/12.2211747

KEYWORDS: Photoacoustic imaging, Neuroimaging, Brain, Tissue optics, In vivo imaging, Tissues, Action potentials, Photoacoustic tomography, Photons, Optical imaging

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Proceedings Article | 11 March 2015 Paper

Label-free optical-resolution photoacoustic endomicroscopy in vivo

Joon-Mo Yang, Chiye Li, Ruimin Chen, Bin Rao, Junjie Yao, Cheng-Hung Yeh, Amos Danielli, Konstantin Maslov, Qifa Zhou, K. Shung, Lihong Wang

Proceedings Volume 9323, 932332 (2015) https://doi.org/10.1117/12.2080224

KEYWORDS: In vivo imaging, Acoustics, GRIN lenses, Transducers, Mirrors, Photoacoustic spectroscopy, Endoscopy, Imaging systems, Optical fibers, Image resolution

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SPIE Journal Paper | 3 March 2014 Open Access

Integrated photoacoustic, confocal, and two-photon microscope

Bin Rao, Florentina Soto, Daniel Kerschensteiner, Lihong Wang

JBO, Vol. 19, Issue 03, 036002, (March 2014) https://doi.org/10.1117/12.10.1117/1.JBO.19.3.036002

KEYWORDS: Confocal microscopy, Luminescence, Microscopes, Mirrors, Microscopy, Absorption, Photoacoustic spectroscopy, Chromophores, Two photon excitation microscopy, Imaging systems

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Proceedings Article | 18 February 2011 Paper

High speed inverted optical-resolution photoacoustic microscopy

Bin Rao, Konstantin Maslov, Amos Danielli, Ruiming Chen, K. Kirk Shung, Qifa Zhou, Lihong Wang

Proceedings Volume 7899, 78990T (2011) https://doi.org/10.1117/12.873568

KEYWORDS: Imaging systems, Transducers, Ultrasonics, Pulsed laser operation, Gold, Photoacoustic microscopy, Tissue optics, In vivo imaging, 3D image processing, Image resolution

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Proceedings Article | 18 February 2011 Paper

Photoacoustic microscopy of human teeth

Bin Rao, Xin Cai, Christopher Favazza, Junjie Yao, Li Li, Steven Duong, Lih-Huei Liaw, Jennifer Holtzman, Petra Wilder-Smith, Lihong Wang

Proceedings Volume 7884, 78840U (2011) https://doi.org/10.1117/12.874070

KEYWORDS: Teeth, Tissue optics, Signal detection, Imaging systems, Photoacoustic microscopy, Pulsed laser operation, Optical imaging, Ultrasonics, Natural surfaces, Near infrared

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Proceedings Article | 3 March 2010 Paper

In vivo, dual-modality imaging of mouse eyes: optical coherence tomography and photoacoustic microscopy within a single instrument

Bin Rao, Li Li, Konstantin Maslov, Lihong Wang

Proceedings Volume 7550, 75501Q (2010) https://doi.org/10.1117/12.843041

KEYWORDS: Optical coherence tomography, In vivo imaging, Image segmentation, Imaging systems, Eye, Tissue optics, Laser safety, Photoacoustic microscopy, Pulsed laser operation, Data acquisition

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Proceedings Article | 24 February 2010 Paper

In vivo label-free photoacoustic microscopy of the anterior segment of the mouse eye

Bin Rao, Song Hu, Li Li, Konstantin Maslov, Lihong Wang

Proceedings Volume 7564, 75643E (2010) https://doi.org/10.1117/12.843052

KEYWORDS: Image segmentation, Imaging systems, In vivo imaging, Eye, Laser safety, Photoacoustic microscopy, Iris recognition, Angiography, Hemodynamics, Ultrasonics

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Proceedings Article | 24 February 2010 Paper

Fast-scanning reflection-mode integrated photoacoustic and optical-coherence microscopy

Li Li, Bin Rao, Konstantin Maslov, Lihong Wang

Proceedings Volume 7564, 75641Z (2010) https://doi.org/10.1117/12.843826

KEYWORDS: Optical coherence tomography, Photoacoustic spectroscopy, Tissue optics, Integrated optics, Image visualization, Soft tissue optics, Microscopy, Microscopes, Imaging systems, Composites

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Proceedings Article | 20 February 2010 Open Access

Three-dimensional speckle suppression in optical coherence tomography based on the curvelet transform

Lingfeng Yu, Zhongping Jian, Bin Rao, Bruce Tromberg, Zhongping Chen

Proceedings Volume 7554, 75542Y (2010) https://doi.org/10.1117/12.841326

KEYWORDS: Optical coherence tomography, Speckle, 3D image processing, Image processing, Signal attenuation, Signal processing, Signal to noise ratio, Interference (communication), Wavelets, Biomedical optics

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Proceedings Article | 3 March 2009 Paper

Rotational second harmonic generation endoscopy with 1µm fiber laser system

Gangjun Liu, Tuqiang Xie, Lingfeng Yu, Jianping Su, Ivan Tomov, Qiang Wang, Bin Rao, Jun Zhang, Zhongping Chen

Proceedings Volume 7172, 71720O (2009) https://doi.org/10.1117/12.808287

KEYWORDS: Fiber lasers, Endoscopy, Microelectromechanical systems, Harmonic generation, Laser systems engineering, Cladding, Microscopy, Diodes, Second-harmonic generation, Amplifiers

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Proceedings Article | 24 February 2009 Paper

Screening retinal transplants with Fourier-domain OCT

Bin Rao

Proceedings Volume 7168, 716828 (2009) https://doi.org/10.1117/12.809547

KEYWORDS: Optical coherence tomography, Surgery, Tissues, Animal model studies, Visual process modeling, Biomedical optics, Medical research, Laser development, Retinal scanning, Imaging systems

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Proceedings Article | 21 February 2009 Paper

Spectral Doppler imaging of micro-vasculature response to laser irradiation

Bin Rao, Wangcun Jia, Lingfeng Yu, Bernard Choi, Ronald Kurtz, J. Stuart Nelson, Zhongping Chen

Proceedings Volume 7168, 71681T (2009) https://doi.org/10.1117/12.809692

KEYWORDS: Doppler tomography, Laser irradiation, Optical coherence tomography, Blood circulation, Ultrasonography, Resistance, Laser speckle imaging, Doppler effect, In vivo imaging, Eye

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SPIE Journal Paper | 1 July 2008 Open Access

Imaging pulsatile retinal blood flow in human eye

Bin Rao, Lingfeng Yu, Huihua Chiang, Leandro Zacharias, Ronald Kurtz, Baruch Kuppermann, Zhongping Chen

JBO, Vol. 13, Issue 04, 040505, (July 2008) https://doi.org/10.1117/12.10.1117/1.2967986

KEYWORDS: Doppler effect, Doppler tomography, Blood circulation, Optical coherence tomography, Eye, Algorithm development, In vivo imaging, Retinal scanning, Imaging systems, Tissues

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Proceedings Article | 28 February 2008 Paper

Thermoelastic optical Doppler tomography of biological tissues

Qiang Wang, Yeh-Chan Ahn, Changsoo Kim, Lingfeng Yu, Wangcun Jia, Bin Rao, Zhongping Chen, HuiHua Chiang

Proceedings Volume 6847, 68471B (2008) https://doi.org/10.1117/12.766962

KEYWORDS: Optical coherence tomography, Tissue optics, Tissues, Thermography, Doppler tomography, Nd:YAG lasers, Biomedical optics, Wave propagation, Q switched lasers, Optical tomography

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Proceedings Article | 11 July 2007 Paper

Coherent amplified optical coherence tomography

Jun Zhang, Bin Rao, Zhongping Chen

Proceedings Volume 6627, 662718 (2007) https://doi.org/10.1117/12.728654

KEYWORDS: Signal to noise ratio, Optical coherence tomography, Image quality, Eye, Light, Tissue optics, Visualization, Image segmentation, Biomedical optics, Sensors

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Proceedings Article | 26 March 2007 Paper

Investigation and visualization of scleral channels created with femtosecond laser in enucleated human eyes using 3D optical coherence tomography images

Gautam Chaudhary, Bin Rao, Dongyul Chai, Zhongping Chen, Tibor Juhasz

Proceedings Volume 6426, 64260B (2007) https://doi.org/10.1117/12.701297

KEYWORDS: Optical coherence tomography, Femtosecond phenomena, 3D image processing, Digital filtering, Image filtering, Visualization, Tissues, Eye, Speckle, Edge detection

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We used optical coherence tomography (OCT) for non-invasive imaging of the anterior segment of the eye for investigating partial-thickness scleral channels created with a femtosecond laser. Glaucoma is associated with elevated intraocular pressure (IOP) due to reduced outflow facility in the eye. A partial-thickness aqueous humor (AH) drainage channel in the sclera was created with 1.7-&mgr;m wavelength femtosecond laser pulses to reduce IOP by increasing the outflow facility, as a solution to retard the progression of glaucoma. It is hypothesized that the precise dimensions and predetermined location of the channel would provide a controlled increase of the outflow rate resulting in IOP reduction. Therefore, it is significant to create the channel at the exact location with predefined dimensions. The aim of this research has two aspects. First, as the drainage channel is subsurface, it is a challenging task to determine its precise location, shape and dimensions, and it becomes very important to investigate the channel attributes after the laser treatment without disturbing the internal anterior structures. Second, to provide a non-invasive, image-based verification that extremely accurate and non-scarring AH drainage channel can be created with femtosecond laser. Partial-thickness scleral channels created in five human cadaver eyes were investigated non-invasively with a 1310-nm time-domain OCT imaging system. Three-dimensional (3D) OCT image stacks of the triangular cornea-sclera junction, also known as anterior chamber angle, were acquired for image-based analysis and visualization. The volumetric cutting-plane approach allowed reconstruction of images at any cross-sectional position in the entire 3D volume of tissue, making it a valuable tool for exploring and evaluating the location, shape and dimension of the channel from all directions. As a two-dimensional image-based methodology, an image-processing pipeline was implemented to enhance the channel features to augment the analysis. In conclusion, we successfully demonstrate that our image-based visualization tool is appropriate for effective investigation and evaluation of femtosecond laser-created, partial-thickness aqueous humor drainage channels in the sclera.

Proceedings Article | 22 February 2007 Paper

Imaging subsurface photodisruption in human sclera with FD-OCT

Bin Rao, Jianping Su, Dongyul Chai, Gautam Chaudhary, Zhongping Chen, Tibor Juhasz

Proceedings Volume 6429, 642910 (2007) https://doi.org/10.1117/12.704857

KEYWORDS: 3D image processing, Sclera, Optical coherence tomography, Femtosecond phenomena, Imaging systems, Laser ablation, Laser tissue interaction, Laser systems engineering, 3D vision, Natural surfaces

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Proceedings Article | 10 February 2007 Paper

Investigation of coherent amplification with a semiconductor optical amplifier employed in a swept source OCT system

Bin Rao, Jun Zhang, Qiang Wang, Zhongping Chen

Proceedings Volume 6429, 642924 (2007) https://doi.org/10.1117/12.704844

KEYWORDS: Signal to noise ratio, Optical coherence tomography, Tissue optics, Optical amplifiers, Signal processing, Semiconductor optical amplifiers, Eye, Reflectors, Sensors, Light

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Proceedings Article | 7 February 2007 Paper

Swept source at 1060 nm for Fourier domain optical coherence tomography

Jun Zhang, Qiang Wang, Bin Rao, Zhongping Chen, Kevin Hsu

Proceedings Volume 6429, 642902 (2007) https://doi.org/10.1117/12.701467

KEYWORDS: Optical coherence tomography, Imaging systems, Laser sources, Optical isolators, Retina, Fiber lasers, Signal detection, Tunable lasers, Tissues, Fabry–Perot interferometers

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Proceedings Article | 22 June 2005 Paper

Fourier domain functional optical coherence tomography

Jun Zhang, Bin Rao, Zhongping Chen

Proceedings Volume 5771, (2005) https://doi.org/10.1117/12.634630

KEYWORDS: Optical coherence tomography, Polarization, Modulators, Mirrors, Phase shifts, Tissue optics, 3D image processing, Doppler tomography, Tissues, Imaging systems

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Proceedings Article | 13 April 2005 Paper

Cartilage disease diagnosis by conventional and polarization-sensitive optical coherence tomography

Tuqiang Xie, Shuguang Guo, Bing Rao, Zhongping Chen, George Peavy

Proceedings Volume 5690, (2005) https://doi.org/10.1117/12.591129

KEYWORDS: Cartilage, Optical coherence tomography, Polarization, Birefringence, Collagen, Image resolution, Tissues, Modulators, Diagnostics, Injuries

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Proceedings Article | 13 July 2004 Paper

Visualizing morphological changes of clear corneal cataract incisions with optical coherence tomography

Bin Rao, Jun Zhang, Mehran Taban, Peter McDonnell, Zhongping Chen

Proceedings Volume 5314, (2004) https://doi.org/10.1117/12.529411

KEYWORDS: Optical coherence tomography, Cornea, Surgery, Eye, Visualization, Natural surfaces, Fluid dynamics, Ophthalmology, Tissues, Clocks

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Showing 5 of 26 publications

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