Photoacoustic imaging (PAI) has been shown to have higher spatial resolution and optical contrast
than conventional ultrasound imaging due to the high contrast absorption of blood on green and near
infrared (NIR) light. We conducted in-vivo PAI of tumor blood vessels - monitoring 3-24 days
development of tumor after the implant of the tumor cells on the back of nude mice. We observed that
the PAI signals increased with the blood vessel developments and the growth of the tumor. This study
shows that PAI is suitable for monitoring of the development of blood vessels near the superficial
tumors. These results demonstrate the usefulness of the PAI for tumor angiogenesis monitoring in
small animals.
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