Dr. Sandy Mosse Profile

Dr. Sandy Mosse

at Univ College London

SPIE Involvement:

Author

Publications (19)

Proceedings Article | 14 August 2019 Presentation

Photodynamic therapy in primary breast cancer: the first human study (Conference Presentation)

Shramana Banerjee, Soha El Sheikh, Anmol Malhotra, Sandy Mosse, Sweta Parker, Norman Williams, Sandy MacRobert, Rifat Hamoudi, Stephen Bown, Mo R. Keshtgar

Proceedings Volume 11070, 1107055 (2019) https://doi.org/10.1117/12.2525480

KEYWORDS: Photodynamic therapy, Breast cancer, Therapeutics, Control systems, Surgery, Magnetic resonance imaging, Breast, Tissues, Clinical trials

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Proceedings Article | 22 July 2019 Paper

Optical interferometric temperature sensors for intravascular blood flow measurements

Elizabeth Carr, Eleanor Mackle, Malcolm Finlay, Charles Mosse, Joanna Coote, Ioannis Papakonstantinou, Adrien Desjardins

Proceedings Volume 11075, 1107502 (2019) https://doi.org/10.1117/12.2527056

KEYWORDS: Domes, Temperature sensors, Sensors, Interferometry, Diffusers, Fiber optics, Blood, Optical fibers

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Proceedings Article | 7 March 2019 Presentation

Ultrasonic needle tracking with a high-finesse Fabry-Perot fiber optic hydrophone (Conference Presentation)

Sunish Mathews, Sandy Mosse, Wenfeng Xia, Dzhoshkun Shakir, Yada Kunpalin, Edward Zhang, Paul Beard, Simeon West, Anna David, Adrien Desjardins

Proceedings Volume 10868, 108681D (2019) https://doi.org/10.1117/12.2509670

KEYWORDS: Ultrasonics, Fiber optics, Fabry–Perot interferometers, Ultrasonography, Sensors, Tissues, Tumors, Biopsy, Nerve, Target designation

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Proceedings Article | 27 February 2019 Paper

3D printed kidney phantoms for an LED-based photoacoustic and ultrasound imaging system

D. Nikitichev, K. Murawski, G. Harris, G. Perkins, S. Mosse, E. Maneas, W. Xia, V. Arumuham, Mithun Kunyuil Ajith Singh, S. Choong, A. Desjardins, J. Hebden

Proceedings Volume 10878, 1087868 (2019) https://doi.org/10.1117/12.2509831

KEYWORDS: Kidney, Photoacoustic spectroscopy, Tissue optics, 3D printing, Ultrasonography, 3D modeling, Acoustics, Printing, Photoacoustic imaging, Tissues

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Proceedings Article | 5 September 2018 Presentation + Paper

3D printed micro-scale fiber optic probe for intravascular pressure sensing

Radhika Poduval, Jo Coote, Charles Mosse, Malcolm Finlay, Ioannis Papakonstantinou, Adrien Desjardins

Proceedings Volume 10728, 107280B (2018) https://doi.org/10.1117/12.2321980

KEYWORDS: Sensors, Fiber optics sensors, Fiber optics, Optical components, Temperature metrology, Computer aided design, Printing, Optical fibers, Interferometry, Two photon polymerization, Blood pressure

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SPIE Journal Paper | 21 August 2018 Open Access

Elastic scattering spectroscopy for early detection of breast cancer: partially supervised Bayesian image classification of scanned sentinel lymph nodes

Zhu Ying, Tom Fearn, D. Wayne Chicken, Martin Austwick, Santosh Somasundaram, Charles Mosse, Benjamin Clark, Irving Bigio, Mohammed R. S. Keshtgar, Stephen Bown

JBO, Vol. 23, Issue 08, 085004, (August 2018) https://doi.org/10.1117/12.10.1117/1.JBO.23.8.085004

KEYWORDS: Image classification, Lymphatic system, Breast cancer, Data modeling, Scattering, Cancer, Spectroscopy, Diagnostics, Imaging spectroscopy, Tissues

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Proceedings Article | 15 March 2018 Presentation

Novel 3D printing technology for direct fabrication of tissue-mimicking phantoms (Conference Presentation)

Daniil Nikitichev, Sandy Mosse, Sebastien Ourselin, Tom Vercauteren

Proceedings Volume 10494, 1049424 (2018) https://doi.org/10.1117/12.2287439

KEYWORDS: 3D printing, Tissues, Ultrasonography, Polymers, Soft tissue optics, Tissue optics, Biomedical optics, Imaging systems, Calibration, Medical devices

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Proceedings Article | 14 March 2018 Presentation

Fibre-optic pressure and temperature measurements using phase-resolved low-coherence interferometry (Conference Presentation)

Joanna Coote, Sandy Mosse, Sacha Noimark, Erwin Alles, Callum Little, Chris Loder, Roby Rakhit, Malcolm Finlay, Adrien Desjardins

Proceedings Volume 10488, 104880E (2018) https://doi.org/10.1117/12.2290007

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Proceedings Article | 27 April 2016 Presentation

All-optical pulse-echo ultrasound probe for intravascular imaging (Conference Presentation)

Richard Colchester, Sacha Noimark, Charles Mosse, Edward Zhang, Paul Beard, Ivan Parkin, Ioannis Papakonstantinou, Adrien Desjardins

Proceedings Volume 9689, 96893I (2016) https://doi.org/10.1117/12.2213757

KEYWORDS: Ultrasonography, Tissues, Intravascular ultrasound, Image resolution, Photoacoustic spectroscopy, Echocardiography, Cardiology, Carbon, Composites, Fabry–Perot interferometers

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Proceedings Article | 16 July 2015 Paper

Fiber optic photoacoustic probe with ultrasonic tracking for guiding minimally invasive procedures

Wenfeng Xia, Charles Mosse, Richard Colchester, Jean Martial Mari, Daniil Nikitichev, Simeon West, Sebastien Ourselin, Paul Beard, Adrien Desjardins

Proceedings Volume 9539, 95390K (2015) https://doi.org/10.1117/12.2182647

KEYWORDS: Ultrasonography, Photoacoustic spectroscopy, Tissues, Tissue optics, Ultrasonics, Receivers, Medical devices, Visualization, Coating, Natural surfaces

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Proceedings Article | 11 March 2015 Paper

Real-time needle guidance with photoacoustic and laser-generated ultrasound probes

Richard Colchester, Charles Mosse, Daniil Nikitichev, Edward Zhang, Simeon West, Paul Beard, Ioannis Papakonstantinou, Adrien Desjardins

Proceedings Volume 9323, 932321 (2015) https://doi.org/10.1117/12.2080772

KEYWORDS: Ultrasonography, Optical fibers, Photoacoustic spectroscopy, Coating, Tissue optics, Tissues, Sensors, Laser beam diagnostics, Blood vessels, Imaging systems

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Proceedings Article | 3 March 2014 Paper

Fiber optic ultrasound transducers with carbon/PDMS composite coatings

Charles Mosse, Richard Colchester, Davinder Bhachu, Edward Zhang, Ioannis Papakonstantinou, Adrien Desjardins

Proceedings Volume 8943, 89430P (2014) https://doi.org/10.1117/12.2037283

KEYWORDS: Optical fibers, Ultrasonography, Optical coatings, Composites, Transducers, Tissue optics, Reflectivity, Natural surfaces, Heart, Carbon nanotubes

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Proceedings Article | 13 March 2013 Paper

Photodynamic therapy of locally advanced pancreatic cancer (VERTPAC study): final clinical results

M. Huggett, M. Jermyn, A. Gillams, S. Mosse, E. Kent, S. Bown, T. Hasan, B. Pogue, S. Pereira

Proceedings Volume 8568, 85680J (2013) https://doi.org/10.1117/12.2013648

KEYWORDS: Photodynamic therapy, Computed tomography, Pancreatic cancer, Fiber lasers, Pancreas, Liver, Cancer, Radiotherapy, Laser tissue interaction, Head

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Proceedings Article | 9 March 2012 Paper

Tissue photosensitizer dosimetry using spectrally-resolved fluorescence for pre-clinical and clinical verteporfin-PDT of pancreatic cancer

Martin Isabelle, Scott Davis, Zan Li, Jason Gunn, P. Hoopes, S. Pereira, C. Mosse, T. Hasan, B. Pogue

Proceedings Volume 8210, 821015 (2012) https://doi.org/10.1117/12.921437

KEYWORDS: Tissue optics, Picosecond phenomena, Tumors, Luminescence, Photodynamic therapy, Tissues, Blood, Spectroscopy, Pancreatic cancer, Skin

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Photodynamic therapy (PDT) mediated with verteporfin is currently being investigated to treat pancreatic cancer in patients who are not surgical candidates. Clinically, interstitial light delivery is administered through a fiber, via percutaneous needle implantation guided by ultrasound and/or verified by CT. Tumor response to PDT is based on photosensitizer (PS) dose, light dose, light dose rate and the timing of light application following PS injection. However, studies have shown that even when matching administered PDT treatment parameters such as drug dose and light level, there can be significant inter-patient variation in tissue damage post-PDT, and this has been primarily attributed to imprecise PS concentration at the target tissue site. In order to achieve optimal tumor response from PDT without causing major damage to surrounding tissue, it would be advantageous to measure the PS concentration in the target tissue just prior to light application. From these measurements, the clinician can adapt the light application dose to the measured target tissue PS concentration (i.e. insufficient target tissue PS concentrations compensated by higher light doses and vice versa.) in order to provide an optimal light dose for each patient. In animal studies, a spectrometer-based in-vivo fluorescence dosimetry system has been used to assess accumulated PS levels (verteporfin) in situ. Measurements are taken from skin, leg muscle, buccal mucosa and tumor tissue locations one hour after injection of the photosensitizer. Real-time spectral fitting, subtraction of background autofluorescence and ratiometric analysis is performed on the raw data to extract out only the photosensitizer fluorescence and therefore concentration. Using a pre-measured calibration data set of varying concentrations for verteporfin in tissue phantoms composed of intralipid and whole blood, it was possible detect concentrations of the photosensitizer below 0.5nM. In the clinical studies being performed at UCL Hospital in which verteporfin-PDT treatment is being given to patients with pancreatic cancer, the dosimetry system is being used to assess PS concentration the pancreatic tumor tissue prior to interstitial light dose treatment. The goal of the work here is to determine whether the dosimetry system can accurately and efficiently be used clinically by evaluating the measured local tissue PS concentration to treatment outcome (area of necrosis established). The results of this study will partially determine the need for fluorescence dosimetry to individualize PDT treatment for patients based on local tissue PS concentration.

SPIE Journal Paper | 1 January 2011 Open Access

Light penetration in the human prostate: a whole prostate clinical study at 763 nm

Caroline Moore, Charles Mosse, Clare Allen, Heather Payne, Mark Emberton, Stephen Bown

JBO, Vol. 16, Issue 1, 015003, (January 2011) https://doi.org/10.1117/12.10.1117/1.3528638

KEYWORDS: Prostate, Sensors, Photodynamic therapy, Optical properties, Diffusers, Tissues, Prostate cancer, Optical testing, Computed tomography, Signal attenuation

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SPIE Journal Paper | 1 July 2010 Open Access

Scanning elastic scattering spectroscopy detects metastatic breast cancer in sentinel lymph nodes

Martin Austwick, Benjamin Clark, Charles Mosse, Kristie Johnson, D. Wayne Chicken, Santosh Somasundaram, Katherine Calabro, Ying Zhu, Mary Falzon, Gabrijela Kocjan, Thomas Fearn, Stephen Bown, Irving Bigio, Mohammed Keshtgar

JBO, Vol. 15, Issue 04, 047001, (July 2010) https://doi.org/10.1117/12.10.1117/1.3463005

KEYWORDS: Lymphatic system, Cancer, Scattering, Tissue optics, Breast cancer, Spectroscopy, Tumors, Tissues, Statistical analysis, Fiber optics

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Proceedings Article | 5 March 2010 Paper

In vivo sampling of Verteporfin uptake in pancreas cancer xenograft models: comparison of surface, oral, and interstitial measurements

Martin Isabelle, Julia O'Hara, Kimberley Samkoe, P. Jack Hoopes, Sandy Mosse, Stephen Pereira, Tayyaba Hasan, Brian Pogue

Proceedings Volume 7551, 755116 (2010) https://doi.org/10.1117/12.852779

KEYWORDS: Picosecond phenomena, Tissues, Tissue optics, Laser induced fluorescence, Photodynamic therapy, Tumors, Pancreas, Natural surfaces, In vivo imaging, Luminescence

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