Prof. Cheol-Woo Park Profile

Prof. Cheol-Woo Park

at Kyungpook National Univ

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Author

Publications (5)

Proceedings Article | 18 March 2023 Paper

Fabrication of nano/microparticles patterns for 3D cell cultures

Gyu Man Kim, Cheol Woo Park, Jang Hoon Seo, Jeong Hwa Kim, Young Hun Jeong

Proceedings Volume 12395, 123950A (2023) https://doi.org/10.1117/12.2668868

KEYWORDS: Particles, Fabrication, Polymers, Surface properties, Cytoskeletons

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Proceedings Article | 26 February 2010 Paper

Evaluation of the cell depleted layer of blood flow in vitro using confocal microscopic PIV method

C. Lee, S. Lim, H. Lee, C. Park

Proceedings Volume 7572, 75720F (2010) https://doi.org/10.1117/12.840151

KEYWORDS: Blood circulation, Confocal microscopy, In vitro testing, Blood, Laser scanners, Microscopes, Opacity, Particle image velocimetry, Spatial resolution, Particles

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Proceedings Article | 25 February 2006 Paper

Early diagnosis of diabetic vascular complications: impairment of red blood cell deformability

Jang-Soo Suh, Sehyun Shin, Yunhee Ku, Cheol-Woo Park

Proceedings Volume 6080, 608014 (2006) https://doi.org/10.1117/12.657383

KEYWORDS: Blood, Diffraction, Protactinium, CCD cameras, Semiconductor lasers, Liquids, Cameras, Pathogens, Chemical elements, Kidney

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Reduced deformability of red blood cells (RBCs) may play an important role on the pathogenesis of chronic vascular complications of diabetes mellitus. However, available techniques for measuring RBC deformability often require washing process after each measurement, which is not optimal for day-to-day clinical use at point of care. The objectives of the present study are to develop a device and to delineate the correlation of impaired RBC deformability with diabetic nephropathy. We developed a disposable ektacytometry to measure RBC deformability, which adopted a laser diffraction technique and slit rheometry. The essential features of this design are its simplicity (ease of operation and no moving parts) and a disposable element which is in contact with the blood sample. We studied adult diabetic patients divided into three groups according to diabetic complications. Group I comprised 57 diabetic patients with normal renal function. Group II comprised 26 diabetic patients with chronic renal failure (CRF). Group III consisted of 30 diabetic subjects with end-stage renal disease (ESRD) on hemodialysis. According to the renal function for the diabetic groups, matched non-diabetic groups were served as control. We found substantially impaired red blood cell deformability in those with normal renal function (group I) compared to non-diabetic control (P = 0.0005). As renal function decreases, an increased impairment in RBC deformability was found. Diabetic patients with chronic renal failure (group II) when compared to non-diabetic controls (CRF) had an apparently greater impairment in RBC deformability (P = 0.07). The non-diabetic cohort (CRF), on the other hand, manifested significant impairment in red blood cell deformability compared to healthy control (P = 0.0001). The newly developed slit ektacytometer can measure the RBC deformability with ease and accuracy. In addition, progressive impairment in cell deformability is associated with renal function loss in all patients regardless of the presence or absence of diabetes. In diabetic patients, early impairment in RBC deformability appears in patients with normal renal function.

Proceedings Article | 6 December 2005 Paper

Hemodynamic investigation on blood flow in a rugged microchannel

G. Kim, S. Shin, J. Jang, C. Park, S. Lee, Y. Ku

Proceedings Volume 6050, 60500Y (2005) https://doi.org/10.1117/12.649749

KEYWORDS: Blood circulation, Blood, Velocity measurements, Particles, Microfluidics, Visualization, CCD cameras, Hemodynamics, Spatial resolution, Computing systems

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Proceedings Article | 18 June 2004 Paper

Micro-PIV measurements of blood flow in a microchannel

Sang-Joon Lee, Cheol-Woo Park, Guk-Bae Kim

Proceedings Volume 5325, (2004) https://doi.org/10.1117/12.529963

KEYWORDS: Blood, Blood circulation, Velocity measurements, Capillaries, Particles, Computing systems, Microfluidics, CCD cameras, Visualization, Blood vessels

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