Accurate dose definition is vital for ensuring optimal radiation therapy (RT) outcomes. The combination of ionizing radiation acoustic imaging (iRAI) and volumetric ultrasound imaging (US) holds the potential for real-time and precise determination of the radiation dose on anatomical structures. We developed an iRAI-US dual-modality system, utilizing a custom 2D matrix array transducer for iRAI and a commercial 2D MAT for US. The studies on phantoms quantified the system performance, and then the experiments using a rabbit liver model in vivo achieved online monitoring of dose on anatomy during RT in real time. These findings demonstrated the potential of iRAI-US combined imaging for personalized RT with improved efficacy and safety.
Ionizing radiation acoustic imaging (iRAI) provides the potential to map the radiation dose during radiotherapy in real time. Described here is our recent development of an iRAI volumetric imaging system in mapping the three-dimensional (3D) radiation dose deposition of a complex clinical radiotherapy treatment plan. Temporal 3D dose accumulation of a treatment plan was first imaged in a phantom. Then, semi-quantitative iRAI measurements were verified with rabbit liver model in vivo. Finally, for the first time, real-time visualization of radiation dose delivered deep in a patient with liver metastases was successfully performed. These studies demonstrate the potential of iRAI to map the dose distribution in deep body during radiotherapy, potentially leading to personalized radiotherapy with optimal efficacy and safety.
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