Dr. Costel Flueraru Profile

Dr. Costel Flueraru

at National Research Council Canada

SPIE Involvement:

Author

Publications (44)

Proceedings Article | 19 May 2022 Presentation + Paper

The effects of radiotherapy on tumour microvasculature: insights from optical coherence angiography and dynamic contrast-enhanced MR imaging towards adaptive radiation medicine

Nader Allam, W. Jeffrey Zabel, Valentin Demidov, Blake Jones, Luuk van der Pol, Warren Foltz, Costel Flueraru, Edward Taylor, I. Alex Vitkin

Proceedings Volume 12147, 121470K (2022) https://doi.org/10.1117/12.2624059

KEYWORDS: Magnetic resonance imaging, Optical coherence tomography, Radiotherapy, Angiography, Medicine, Gadolinium, Data acquisition, Oxygen, Data processing, Pre-clinical research

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Stereotactic body radiotherapy (SBRT) shows promise for increasing local tumour control for many of the most lethal cancer types including pancreatic ductal carcinoma (PDA), compared to conventional radiotherapy. Yet SBRT radiation fractionation schedules may still be improved as its mechanism of action remains largely unknown. It has been suggested that this accelerated hypofractionated treatment benefits from vascular damage (in particular of blood capillaries ~10-30μm in diameter). We therefore hypothesize that monitoring radiation-induced microvascular changes will (1) yield insights into SBRT’s radiobiological effects, and (2) enable predictions of long-term tumour response. We addressed this hypothesis pre-clinically in PDA human xenografts grown in immunocompromised mice in a dorsal skinfold window chamber model. We monitored both micro- (via optical coherence tomography angiography (OCTA)) and macro- (via dynamic contrast enhanced magnetic resonance imaging (DCE-MRI)) vascular responses to irradiation over time. We first studied responses to single fraction irradiation, and then to a full typical clinical SBRT regimen delivered via a small animal irradiator. Candidate predictive vascular biomarkers of radiobiological relevance were derived from 3D OCTA microvascular networks (micro-scale response) and correlated with the DCE-MRI functional metrics relating to the transport of an MRI contrast agent (macro-scale response). The longitudinal trajectories of both were measured before, during and following treatments. Herein we focus primarily on the DLF150 and λ metrics from OCTA which describe the microvascular heterogeneity and molecular transport efficiency. To assess the predictive power of the various metrics, their temporal trends were compared to the macroscopic tumour response (volume and viability). Efforts are ongoing to train neural networks for this time series analysis. The combined OCTA and DCE-MRI insights should yield a better understanding of tissue functional response to high doses of radiation employed in SBRT and help develop improved SBRT fractionation schedules (dose and time combinations) towards personalized and adaptive radiation therapy.

Proceedings Article | 3 June 2019 Paper

OCT lymphangiography based on speckle statistics evaluation

Lev Matveev, Valentin Demidov, Marina Sirotkina, Dmitry Karashtin, Alexander Moiseev, Ivan Popov, Alexander Sovetsky, Alexander Matveyev, Olga Demidova, Grigory Gelikonov, Costel Flueraru, Elena Zagaynova, Natalia Gladkova, Vladimir Zaitsev, I. Alex Vitkin

Proceedings Volume 11065, 1106502 (2019) https://doi.org/10.1117/12.2523291

KEYWORDS: Speckle, Optical coherence tomography, Lymphatic system, Tissues, Tumors, Interference (communication), Signal attenuation, Angiography, Visualization, In vivo imaging

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SPIE Journal Paper | 12 October 2018 Open Access

Preclinical quantitative in-vivo assessment of skin tissue vascularity in radiation-induced fibrosis with optical coherence tomography

Valentin Demidov, Xiao Zhao, Olga Demidova, Hilary Y. M. Pang, Costel Flueraru, Fei-Fei Liu, I. Alex Vitkin

JBO, Vol. 23, Issue 10, 106003, (October 2018) https://doi.org/10.1117/12.10.1117/1.JBO.23.10.106003

KEYWORDS: Skin, Optical coherence tomography, Tissues, In vivo imaging, Tissue optics, Visualization, Capillaries, Cancer, Natural surfaces, Toxicity

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Proceedings Article | 24 May 2018 Presentation

Pre-clinical parametric imaging for tumor delineation with optical coherence tomography (Conference Presentation)

Valentin Demidov, Dina Guryanova, Costel Flueraru, I. Alex Vitkin

Proceedings Volume 10685, 106851U (2018) https://doi.org/10.1117/12.2309744

KEYWORDS: Tumors, Optical coherence tomography, Tissues, Image segmentation, 3D image processing, Speckle, Confocal microscopy, Luminescence, Melanoma, Skin

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Proceedings Article | 7 November 2012 Paper

Instantaneous spectroscopic SS-OCT imaging using a simultaneous dual-band swept laser and common-path fiber probe

Youxin Mao, Shoude Chang, Costel Flueraru, Erroll Murdock

Proceedings Volume 8421, 84215O (2012) https://doi.org/10.1117/12.974738

KEYWORDS: Optical coherence tomography, Spectroscopy, Fiber lasers, GRIN lenses, Imaging spectroscopy, Laser sources, In vivo imaging, Optical filters, Phase measurement, Polygon scanners

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Proceedings Article | 16 September 2011 Paper

Simultaneous multi-wavelength-band optical frequency domain imaging for spectroscopic investigations

Youxin Mao, Shoude Chang, Erroll Murdock, Costel Flueraru

Proceedings Volume 8155, 81551A (2011) https://doi.org/10.1117/12.901161

KEYWORDS: Optical coherence tomography, Spectroscopy, Optical imaging, Optical filters, Polygon scanners, Imaging spectroscopy, Laser sources, Wavelength division multiplexing, Scanners, In vivo imaging

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Proceedings Article | 31 August 2011 Paper

Labview programming for swept-source full-field optical coherence tomography

Shoude Chang, Youxin Mao, Costel Flueraru

Proceedings Volume 8007, 800705 (2011) https://doi.org/10.1117/12.902703

KEYWORDS: Optical coherence tomography, LabVIEW, Signal detection, 3D image processing, Video, Wavelength tuning, Computer programming, Fourier transforms, Image restoration, Imaging systems

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Proceedings Article | 31 August 2011 Paper

Simultaneous 1310/1550 dual-band swept laser source and fiber-based dual-band common-path swept source optical coherence tomography

Youxin Mao, Shoude Chang, Erroll Murdock, Costel Flueraru

Proceedings Volume 8007, 800704 (2011) https://doi.org/10.1117/12.902617

KEYWORDS: Optical coherence tomography, Optical filters, Laser sources, Spectroscopy, Polygon scanners, Wavelength division multiplexing, Solids, In vivo imaging, Mirrors, Image processing

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Proceedings Article | 11 November 2010 Paper

Optical coherence tomography used for jade industry

Shoude Chang, Youxin Mao, Guangming Chang, Costel Flueraru

Proceedings Volume 7855, 785514 (2010) https://doi.org/10.1117/12.868577

KEYWORDS: Optical coherence tomography, Signal detection, Image segmentation, Light sources, Sensors, Fourier transforms, Biological research, Statistical analysis, Diagnostics, Image resolution

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Proceedings Article | 21 September 2010 Paper

Detection and analysis of jade material using optical coherence tomography

Shoude Chang, Youxin Mao, Guangming Chang, Costel Flueraru

Proceedings Volume 7750, 77500I (2010) https://doi.org/10.1117/12.872724

KEYWORDS: Optical coherence tomography, Signal detection, Light sources, Diagnostics, Imaging systems, Interferometers, Erbium, Mirrors, Image resolution, Fourier transforms

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Proceedings Article | 21 September 2010 Paper

Spectral signal processing in swept source optical coherence tomography

Shoude Chang, Youxin Mao, Costel Flueraru

Proceedings Volume 7750, 77500A (2010) https://doi.org/10.1117/12.872874

KEYWORDS: Optical coherence tomography, Fourier transforms, Sensors, Light sources, Image filtering, Linear filtering, Signal detection, Signal processing, Imaging systems, Bandpass filters

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Proceedings Article | 16 September 2010 Paper

Images of arterial tissues using catheter swept source optical coherence tomography

Youxin Mao, Costel Flueraru, Shoude Chang, Dan Popescu, M. Sowa

Proceedings Volume 7750, 77500C (2010) https://doi.org/10.1117/12.872422

KEYWORDS: Optical coherence tomography, Tissues, Signal to noise ratio, Blood circulation, Arteries, Biomedical optics, Interferometers, Tissue optics, Semiconductor optical amplifiers, In vivo imaging

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SPIE Journal Paper | 1 June 2010

Jade detection and analysis based on optical coherence tomography images

Shoude Chang, Yinxin Mao, Guangming Chang, Costel Flueraru

OE, Vol. 49, Issue 06, 063602, (June 2010) https://doi.org/10.1117/12.10.1117/1.3449112

KEYWORDS: Optical coherence tomography, Statistical analysis, Translucency, Image segmentation, Optical engineering, Imaging systems, Diagnostics, Light sources, Image resolution, Eye

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Proceedings Article | 23 February 2010 Paper

Extracting information from optical coherence tomography images of tissues: signal attenuation and fractal analysis of speckle pattern

Dan Popescu, Costel Flueraru, Youxin Mao, Shoude Chang, Michael Sowa

Proceedings Volume 7555, 75550C (2010) https://doi.org/10.1117/12.839791

KEYWORDS: Optical coherence tomography, Signal attenuation, Fractal analysis, Tissues, Arteries, Blood circulation, Signal detection, Head, Speckle pattern, Image analysis

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Proceedings Article | 29 August 2009 Paper

Complex swept source optical coherence tomography with ultra-small fiber probe for biomedical imaging

Youxin Mao, Shoude Chang, Costel Flueraru

Proceedings Volume 7382, 73820B (2009) https://doi.org/10.1117/12.835363

KEYWORDS: GRIN lenses, Optical coherence tomography, Biomedical optics, Imaging systems, Signal detection, Tissue optics, Tissues, Interferometers, Interferometry, In vivo imaging

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Proceedings Article | 5 August 2009 Paper

Swept-source full-field optical coherence microscopy

Shoude Chang, Sherif Sherif, Youxin Mao, Costel Flueraru

Proceedings Volume 7386, 738604 (2009) https://doi.org/10.1117/12.838213

KEYWORDS: Optical coherence tomography, Mirrors, Image resolution, Imaging systems, Microscopes, Optical coherence microscopy, Signal to noise ratio, Tissue optics, Field programmable gate arrays, Interferometers

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Proceedings Article | 13 July 2009 Paper

Catheter-based complex swept source optical coherence tomography for biomedical imaging

Youxin Mao, Costel Flueraru, Shoude Chang

Proceedings Volume 7380, 73806Q (2009) https://doi.org/10.1117/12.828233

KEYWORDS: GRIN lenses, Optical coherence tomography, Biomedical optics, Imaging systems, Signal detection, Tissue optics, Tissues, Interferometers, Interferometry, In vivo imaging

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Proceedings Article | 8 July 2009 Paper

Quantitative analysis of arterial tissue with optical coherence tomography

Costel Flueraru, Dan Popescu, Youxin Mao, Shoude Chang, Michael Sowa

Proceedings Volume 7368, 736817 (2009) https://doi.org/10.1117/12.831617

KEYWORDS: Optical coherence tomography, Signal attenuation, Tissue optics, Blood circulation, Scattering, Data modeling, Quantitative analysis, Light scattering, Tissues, Confocal microscopy

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Proceedings Article | 27 January 2009 Paper

Optical coherence tomography: technology and applications

Shoude Chang, Youxin Mao, Costel Flueraru, Sherif Sherif

Proceedings Volume 7156, 715606 (2009) https://doi.org/10.1117/12.806813

KEYWORDS: Optical coherence tomography, Tomography, Light sources, Tissues, Imaging systems, Interferometers, Cameras, Image resolution, Mirrors, Fourier transforms

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Proceedings Article | 12 August 2008 Paper

3x3 MZI with unbalanced differential detection for full range swept-source optical coherence tomography

Youxin Mao, Costel Flueraru, Sherif Sherif, Shoude Chang

Proceedings Volume 7099, 709909 (2008) https://doi.org/10.1117/12.807440

KEYWORDS: Optical coherence tomography, Interferometry, Signal detection, Sensors, Fiber couplers, Interferometers, Mach-Zehnder interferometers, Signal to noise ratio, Signal attenuation, Phase shifts

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Proceedings Article | 12 August 2008 Paper

Fiber probes used in optical coherence tomography

Youxin Mao, Shoude Chang, Sherif Sherif, Costel Flueraru

Proceedings Volume 7099, 70990A (2008) https://doi.org/10.1117/12.807442

KEYWORDS: GRIN lenses, Optical coherence tomography, In vivo imaging, Tissue optics, Lenses, Doppler tomography, Imaging systems, Zemax, Biomedical optics, Tissues

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Proceedings Article | 8 January 2008 Paper

Design and implementation of fiber lenses for ultra-small probes used in biomedical imaging

Youxin Mao, Shoude Chang, Sherif Sherif, Costel Flueraru

Proceedings Volume 6826, 68261A (2008) https://doi.org/10.1117/12.754725

KEYWORDS: GRIN lenses, Optical coherence tomography, Biomedical optics, Lenses, Imaging systems, In vivo imaging, Tissue optics, Doppler tomography, Tissues, Zemax

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Proceedings Article | 26 October 2007 Paper

Numerical dispersion compensation for optical coherence tomography in the Wigner domain

Sherif Sherif, Kalon Huff, Wahab Almuhtadi, Costel Flueraru, Youxin Mao, Shoude Chang

Proceedings Volume 6796, 67960G (2007) https://doi.org/10.1117/12.778060

KEYWORDS: Optical coherence tomography, Wigner distribution functions, Dispersion, Interferometers, Deconvolution, Tissue optics, Interfaces, Optical resolution, Electronic filtering, Time-frequency analysis

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Proceedings Article | 26 October 2007 Paper

Large area full-field optical coherence tomography using white light source

Shoude Chang, Youxin Mao, Sherif Sherif, Costel Flueraru

Proceedings Volume 6796, 67961F (2007) https://doi.org/10.1117/12.778741

KEYWORDS: Optical coherence tomography, Light sources, Halogens, Tomography, Imaging systems, Lamps, Stereoscopy, 3D image processing, Interferometers, 3D metrology

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Proceedings Article | 26 October 2007 Paper

Sensitivity investigation of instantaneous complex conjugate resolved swept-source OCT using a Mach-Zehnder interferometer with a 3x3 fiber coupler

Youxin Mao, Costel Flueraru, Sherif Sherif, Shoude Chang, E. Murdock

Proceedings Volume 6796, 67960F (2007) https://doi.org/10.1117/12.778058

KEYWORDS: Optical coherence tomography, Signal detection, Interferometry, Fiber couplers, Mach-Zehnder interferometers, Signal to noise ratio, Sensors, Optical fibers, Interference (communication), Interferometers

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Proceedings Article | 26 October 2007 Paper

Optical coherence tomography used for internal biometrics

Shoude Chang, Sherif Sherif, Youxin Mao, Costel Flueraru

Proceedings Volume 6796, 67962C (2007) https://doi.org/10.1117/12.778910

KEYWORDS: Optical coherence tomography, Biometrics, Iris recognition, Skin, Fingerprint recognition, Security technologies, 3D image processing, Information security, Spectroscopy, Tissue optics

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Proceedings Article | 11 July 2007 Paper

Maximum likelihood estimation of depth reflectance in time-domain optical coherence tomography

Sherif Sherif, Costel Flueraru, Youxin Mao, Shoude Chang

Proceedings Volume 6627, 66270S (2007) https://doi.org/10.1117/12.728024

KEYWORDS: Optical coherence tomography, Reflectivity, Sensors, Process modeling, Image restoration, Coherence (optics), Biomedical optics, Thermal effects, Computer simulations, Refractive index

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Proceedings Article | 28 September 2006 Paper

Full-field optical coherence tomography used for security and document identity

Shoude Chang, Youxin Mao, Sherif Sherif, Costel Flueraru

Proceedings Volume 6402, 64020Q (2006) https://doi.org/10.1117/12.692733

KEYWORDS: Optical coherence tomography, Tomography, Information security, Cameras, Imaging systems, Light sources, 3D image processing, Skin, Image resolution, Biometrics

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Proceedings Article | 8 September 2006 Paper

Large area full-field optical coherence tomography

Shoude Chang, Sherif Sherif, Costel Flueraru

Proceedings Volume 6343, 634302 (2006) https://doi.org/10.1117/12.706543

KEYWORDS: Optical coherence tomography, Tomography, Imaging systems, Cameras, Stereoscopy, Image segmentation, Image resolution, Light sources, 3D image processing, Interferometers

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Proceedings Article | 8 September 2006 Paper

Statistics of A-scan photocurrent in time-domain optical coherence tomography

Sherif Sherif, Shoude Chang, Costel Flueraru

Proceedings Volume 6343, 63430F (2006) https://doi.org/10.1117/12.707492

KEYWORDS: Optical coherence tomography, Reflectivity, Photodetectors, Error analysis, Statistical modeling, Tissue optics, Sensors, Biological research, Natural surfaces, Spatial resolution

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Proceedings Article | 8 September 2006 Paper

Novel quadrature interferometric platform with application in optical coherence tomography

C. Flueraru, H. Kumazaki, S. Sherif, S. Chang

Proceedings Volume 6343, 63430G (2006) https://doi.org/10.1117/12.707493

KEYWORDS: Interferometry, Phase shifts, Optical coherence tomography, Interferometers, Mirrors, Sensors, Signal detection, Scattering, Light sources, 3D image processing

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SPIE Journal Paper | 1 July 2006

Compact system for measurement of optical surfaces having a large radius of curvature

Xianyang Cai, Shoude Chang, Costel Flueraru

OE, Vol. 45, Issue 07, 073603, (July 2006) https://doi.org/10.1117/12.10.1117/1.2219101

KEYWORDS: Zoom lenses, Calibration, Optical testing, Lens design, Wavefronts, Spherical lenses, Error analysis, Interferometers, Optical engineering, Fizeau interferometers

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Proceedings Article | 15 October 2005 Paper

Extend focal depth of a tracking lens by phase apodizers

Xianyang Cai, Shoude Chang, Costel Flueraru

Proceedings Volume 5962, 596216 (2005) https://doi.org/10.1117/12.625007

KEYWORDS: Point spread functions, Binary data, Imaging systems, Particles, Particle systems, Lens design, 3D image processing, Diffraction, Optical tracking, Numerical analysis

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Proceedings Article | 14 October 2005 Paper

Resolution enhancement for an OCT system applied to multiple-layer information extraction

Xianyang Cai, Shoude Chang, Erroll Murdock, Costel Flueraru

Proceedings Volume 5969, 59692D (2005) https://doi.org/10.1117/12.628128

KEYWORDS: Optical coherence tomography, Tomography, Image retrieval, Phase shifts, Light sources, Resolution enhancement technologies, Imaging systems, Image resolution, Reflectivity, Image quality

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Proceedings Article | 27 August 2005 Paper

Polarimetry: measurements, error analysis, and application

C. Flueraru, X. Cai, S. Chang

Proceedings Volume 5858, 58580H (2005) https://doi.org/10.1117/12.612648

KEYWORDS: Wave plates, Polarizers, Polarimetry, Polarization, Linear polarizers, Sensors, Error analysis, Optical testing, Optical components, Beam splitters

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Proceedings Article | 13 June 2005 Paper

2D parallel optical coherence tomography and multiple-layer information extraction

Shoude Chang, Xianyang Cai, Erroll Murdock, Costel Flueraru

Proceedings Volume 5856, (2005) https://doi.org/10.1117/12.611825

KEYWORDS: Optical coherence tomography, Tomography, Cameras, Modulation, Phase shift keying, Image processing, Scattering, Spatial frequencies, Phase modulation, CCD cameras

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Proceedings Article | 20 December 2004 Paper

One-to-four optical waveguide power splitters fabricated in fused silica glass using a femtosecond laser

Jiaren Liu, Zhiyi Zhang, Shoude Chang, Costel Flueraru, Chander Grover

Proceedings Volume 5577, (2004) https://doi.org/10.1117/12.567080

KEYWORDS: Waveguides, Femtosecond phenomena, Glasses, Silica, Integrated optics, Directional couplers, Fabrication, Polarization, Optical circuits, Photonic devices

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Proceedings Article | 20 December 2004 Paper

Fabrication and optimization of one-to-two and two-to-two optical directional couplers in glass using a femtosecond laser

Jiaren Liu, Zhiyi Zhang, Shoude Chang, Costel Flueraru, Chander Grover

Proceedings Volume 5577, (2004) https://doi.org/10.1117/12.567083

KEYWORDS: Waveguides, Directional couplers, Femtosecond phenomena, Glasses, Refractive index, Silica, Optical filters, Dielectrics, Integrated optics, Optical switching

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Proceedings Article | 20 December 2004 Paper

Second-order susceptibility measurement of thin films by reflective second harmonic generation method: toward measurement standards in nonlinear optics

Costel Flueraru, Chander Grover

Proceedings Volume 5577, (2004) https://doi.org/10.1117/12.567494

KEYWORDS: Second-harmonic generation, Quartz, Thin films, Reflectivity, Polarization, Polarizers, Calibration, Harmonic generation, Statistical analysis, Nonlinear optics

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Proceedings Article | 16 November 2004 Paper

Accuracy issues in polarization mode dispersion measurements: Stokes parameter evaluation technique, state-of-polarization method, and fixed analyzer technique

Costel Flueraru, Jiaren Liu, Chander Grover

Proceedings Volume 5579, (2004) https://doi.org/10.1117/12.567477

KEYWORDS: Polarization, Polarimetry, Wave plates, Polarizers, Picosecond phenomena, Optical fibers, Interferometry, Telecommunications, Sensors, Optical spheres

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Proceedings Article | 1 September 2004 Paper

Design of a novel star tracker optical system

Xinping Liu, Xianyang Cai, Costel Flueraru, Shoude Chang, Chander Grover

Proceedings Volume 5418, (2004) https://doi.org/10.1117/12.541609

KEYWORDS: Stars, Distortion, Optical tracking, Image sensors, CCD image sensors, Lens design, Glasses, Imaging systems, Aspheric lenses, Point spread functions

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Proceedings Article | 15 December 2003 Paper

Extremely flat ultrawideband supercontinuum for WDM/TDM applications

Ahmad Atieh, Costel Flueraru, Chander Grover

Proceedings Volume 5260, (2003) https://doi.org/10.1117/12.543177

KEYWORDS: Solitons, Dispersion, Fiber lasers, Polarization, Raman spectroscopy, Fiber amplifiers, Supercontinuum sources, Wavelength division multiplexing, Telecommunications, Picosecond phenomena

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Proceedings Article | 25 November 2002 Paper

Investigation of inverted and noninverted organic planar waveguide toward nonlinear optical devices

Costel Flueraru, Chander Grover, Sigurd Schrader, Hubert Motschmann

Proceedings Volume 4805, (2002) https://doi.org/10.1117/12.450897

KEYWORDS: Waveguides, Refractive index, Phase modulation, Second-harmonic generation, Nonlinear optics, Thin films, Planar waveguides, Harmonic generation, Liquids, Tunable lasers

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Proceedings Article | 7 December 2001 Paper

Phase-matched second harmonic generation and nonlinear phase shift in a Langmuir-Blodgett film waveguide

Sigurd Schrader, Costel Flueraru, Hubert Motschmann, Ludwig Brehmer

Proceedings Volume 4461, (2001) https://doi.org/10.1117/12.449835

KEYWORDS: Second-harmonic generation, Refractive index, Phase shifts, Polarization, Harmonic generation, Nonlinear optics, Chromophores, Quartz, Glasses, Interferometry

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Showing 5 of 44 publications

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