Dr. Damon T. DePaoli Profile

Dr. Damon T. DePaoli

I am a PhD candidate in biophotonics at CERVO Brain Research center in Quebec City, Canada. My thesis research allows me to investigate the optical properties of the brain using various spectroscopies and to apply that investigation in the development of smart neurosurgical systems.

Proceedings Article | 13 March 2024 Presentation

Human brain tissue identification using CARS and DRS for deep brain stimulation surgery

Mireille Quémener, Sébastien Jerczynski, Valérie Pineau Noël, Antoine Rousseau, Elahe Parham, Alexandre Bédard, Thomas Charland, Anthony Drouin, Jonathan Roussel, Valérie Dionne, Thomas Shooner, Anaïs Parrot, Shadi Masoumi, Damon DePaoli, Leo Cantin, Martin Parent, Daniel Côté

Proceedings Volume PC12831, PC1283103 (2024) https://doi.org/10.1117/12.3000974

KEYWORDS: Brain tissue, Surgery, Brain stimulation, Tissue optics, Lead, Principal component analysis, Brain, Standards development, Magnetic resonance imaging, Electrodes

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SPIE Journal Paper | 17 April 2023 Open Access

Development of polarization-sensitive optical coherence tomography imaging platform and metrics to quantify electrostimulation-induced peripheral nerve injury in vivo in a small animal model

Guillermo Monroy, Mohsen Erfanzadeh, Michael Tao, Damon DePaoli, Ilyas Saytashev, Ahhyun Stephanie Nam, Harmain Rafi, Kasey Kwong, Katherine Shea, Benjamin Vakoc, Srikanth Vasudevan, Daniel Hammer

NPh, Vol. 10, Issue 02, 025004, (April 2023) https://doi.org/10.1117/12.10.1117/1.NPh.10.2.025004

KEYWORDS: Nerve, Optical coherence tomography, Coherence imaging, Animals, Nervous system, Injuries, Biological imaging, Optical imaging, Image segmentation, Tissue optics

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SignificanceNeuromodulation devices are rapidly evolving for the treatment of neurological diseases and conditions. Injury from implantation or long-term use without obvious functional losses is often only detectable through terminal histology. New technologies are needed that assess the peripheral nervous system (PNS) under normal and diseased or injured conditions.AimWe aim to demonstrate an imaging and stimulation platform that can elucidate the biological mechanisms and impacts of neurostimulation in the PNS and apply it to the sciatic nerve to extract imaging metrics indicating electrical overstimulation.ApproachA sciatic nerve injury model in a 15-rat cohort was observed using a newly developed imaging and stimulation platform that can detect electrical overstimulation effects with polarization-sensitive optical coherence tomography. The sciatic nerve was electrically stimulated using a custom-developed nerve holder with embedded electrodes for 1 h, followed by a 1-h recovery period, delivered at above-threshold Shannon model k-values in experimental groups: sham control (SC, n = 5, 0.0 mA / 0 Hz), stimulation level 1 (SL1, n = 5, 3.4 mA / 50 Hz, and k = 2.57), and stimulation level 2 (SL2, n = 5, 6.8 mA / 100 Hz, and k = 3.17).ResultsThe stimulation and imaging system successfully captured study data across the cohort. When compared to a SC after a 1-week recovery, the fascicle closest to the stimulation lead showed an average change of +4 % / − 309 % (SL1/SL2) in phase retardation and −79 % / − 148 % in optical attenuation relative to SC. Analysis of immunohistochemistry (IHC) shows a +1 % / − 36 % difference in myelin pixel counts and −13 % / + 29 % difference in axon pixel counts, and an overall increase in cell nuclei pixel count of +20 % / + 35 % . These metrics were consistent with IHC and hematoxylin/eosin tissue section analysis.ConclusionsThe poststimulation changes observed in our study are manifestations of nerve injury and repair, specifically degeneration and angiogenesis. Optical imaging metrics quantify these processes and may help evaluate the safety and efficacy of neuromodulation devices.

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Proceedings Article | 17 March 2023 Presentation

Diffuse reflectance spectroscopy for optical guidance in neurosurgery and design of a multimodal optic probe

Alexandre Bédard, Pegah Eslami, Damon Depaoli, Mireille Quémener, Martin Parent, Daniel Côté

Proceedings Volume 12364, 1236407 (2023) https://doi.org/10.1117/12.2649348

KEYWORDS: Diffuse reflectance spectroscopy, Principal component analysis, Brain, Tissues, Tissue optics, Surgery, Safety, Resistance, Electrodes, Computer simulations

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Proceedings Article | 7 March 2022 Presentation

High fidelity polarization-sensitive optical coherence tomography through deep learning

Ludovick Bégin, Damon DePaoli, Brett Bouma, Daniel Côté, Martin Villiger

Proceedings Volume PC11963, PC119630F (2022) https://doi.org/10.1117/12.2608232

KEYWORDS: Optical coherence tomography, Reconstruction algorithms, Tissue optics, Speckle, Polarization, Data modeling, Birefringence, Tissues, Signal attenuation, Scattering

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Proceedings Article | 5 March 2021 Presentation

Reconstruction of tissue birefringence from polarization-sensitive optical coherence tomography using machine learning

Ludovick Bégin, Damon DePaoli, Brett Bouma, Daniel Côté, Martin Villiger

Proceedings Volume 11646, 1164612 (2021) https://doi.org/10.1117/12.2578448

KEYWORDS: Tissue optics, Birefringence, Optical coherence tomography, Network architectures, Speckle, Polarization, Machine learning, Tissues, Systems modeling, Statistical modeling

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Proceedings Article | 5 March 2021 Presentation

Endoscopic optic-axis mapping of white matter fiber tracts using polarization-sensitive optical coherence tomography

Damon DePaoli, Daniel Côté, Brett Bouma, Martin Villiger

Proceedings Volume 11629, 116290S (2021) https://doi.org/10.1117/12.2577859

KEYWORDS: Optical coherence tomography, Imaging systems, Endoscopy, Brain mapping, Polarization, Brain, Scattering, Neuroimaging, Magnetic resonance imaging, Light scattering

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SPIE Journal Paper | 1 May 2020 Open Access

Rise of Raman spectroscopy in neurosurgery: a review

Damon DePaoli, Émile Lemoine, Katherine Ember, Martin Parent, Michel Prud’homme, Léo Cantin, Kevin Petrecca, Frédéric Leblond, Daniel Côté

JBO, Vol. 25, Issue 05, 050901, (May 2020) https://doi.org/10.1117/12.10.1117/1.JBO.25.5.050901

KEYWORDS: Raman spectroscopy, Tissues, Brain, Tissue optics, Remote sensing, Imaging systems, Chromium, Tumors, Signal processing, Biopsy

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SPIE Journal Paper | 10 March 2020 Open Access

Anisotropic light scattering from myelinated axons in the spinal cord

Damon DePaoli, Alicja Gasecka, Mohamed Bahdine, Jean Deschenes, Laurent Goetz, Jimena Perez-Sanchez, Robert Bonin, Yves De Koninck, Martin Parent, Daniel Côté

NPh, Vol. 7, Issue 01, 015011, (March 2020) https://doi.org/10.1117/12.10.1117/1.NPh.7.1.015011

KEYWORDS: Spinal cord, Scattering, Light scattering, Tissue optics, Axons, Monte Carlo methods, Tissues, Optogenetics, Brain, Integrating spheres

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SPIE Journal Paper | 17 August 2018 Open Access

Intact primate brain tissue identification using a completely fibered coherent Raman spectroscopy system

Damon DePaoli, Nicolas Lapointe, Younès Messaddeq, Martin Parent, Daniel Côté

NPh, Vol. 5, Issue 03, 035005, (August 2018) https://doi.org/10.1117/12.10.1117/1.NPh.5.3.035005

KEYWORDS: Brain, Raman spectroscopy, Tissues, Electrodes, Signal detection, Fiber lasers, Tissue optics, Laser systems engineering, Signal generators, Spectroscopy

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Proceedings Article | 26 April 2016 Presentation

Fiber-based tissue identification for electrode placement in deep brain stimulation neurosurgery (Conference Presentation)

Damon DePaoli, Nicolas Lapointe, Laurent Goetz, Martin Parent, Michel Prudhomme, Léo Cantin, Tigran Galstian, Younès Messaddeq, Daniel Côté

Proceedings Volume 9690, 96900G (2016) https://doi.org/10.1117/12.2213353

KEYWORDS: Electrodes, Brain stimulation, Tissues, Brain, In vitro testing, Optical design, Optical fibers, Biosensing, Tissue optics, Blood vessels

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SPIE Journal Paper | 21 December 2015 Open Access

Quebec City Frontiers in Neurophotonics 2015 captures the vast spectrum of optical approaches for studying the brain

Damon DePaoli, Gabriel Nadeau, Benoît Audet, Arutyun Bagramyan

NPh, Vol. 2, Issue 04, 040401, (December 2015) https://doi.org/10.1117/12.10.1117/1.NPh.2.4.040401

KEYWORDS: Neurophotonics, Brain, Neurons, Proteins, Super resolution, Tissues, Tissue optics, Fiber optics, Objectives, Signal processing

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