Prof. Dan Fu Profile

Prof. Dan Fu

Associate Professor at Univ of Washington

SPIE Involvement:

Conference Program Committee | Editorial Board Member: Journal of Biomedical Optics | Author

Publications (25)

Proceedings Article | 13 March 2024 Presentation

Facilitated transport of EGFR inhibitors plays an important role in their cellular uptake

Erin Dunnington, Brian S. Wong, Ruibing Wu, Jonathan Kim, Kailun Hu, Thomas Ro, Dan Fu

Proceedings Volume PC12855, PC128550G (2024) https://doi.org/10.1117/12.2692986

KEYWORDS: Raman scattering, Microscopy, Visualization, Resistance, Lung cancer, Live cell imaging, Visual analytics, Vibration, Temporal resolution, Proteins

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SPIE Journal Paper | 24 January 2024 Open Access

Discrimination of lipid composition and cellular localization in human liver tissues by stimulated Raman scattering microscopy

Fiona Xi Xu, George Ioannou, Sum Lee, Christopher Savard, Christian Horn, Dan Fu

JBO, Vol. 29, Issue 01, 016008, (January 2024) https://doi.org/10.1117/12.10.1117/1.JBO.29.1.016008

KEYWORDS: Tissues, Liver, Molecules, Microscopy, Crystals, Polarization, Imaging systems, Body composition, Hyperspectral imaging, Raman spectroscopy

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Proceedings Article | 17 March 2023 Poster

High-throughput, single-cell drug response measurement using quantitative phase microscopy

Fiona Xu, Dan Fu

Proceedings Volume PC12389, PC1238911 (2023) https://doi.org/10.1117/12.2649431

KEYWORDS: Phase measurement, Microscopy, Resistance, Cancer, Tumors, Testing and analysis, Oncology, Image processing, Image acquisition, Binary data

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Proceedings Article | 15 March 2023 Presentation + Paper

Characterization of lipid composition and localization at different stages of nonalcoholic fatty liver disease using stimulated Raman scattering microscopy

Fiona Xi Xu, George Ioannou, Sum Lee, Christopher Savard, Dan Fu

Proceedings Volume 12392, 1239208 (2023) https://doi.org/10.1117/12.2649422

KEYWORDS: Tissues, Liver, Molecules, Microscopy, Diseases and disorders, Hyperspectral imaging, Body composition, Crystals, Raman scattering, Polarization

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Proceedings Article | 15 March 2023 Presentation

Machine learning augmented cell imaging and classification with stimulated Raman scattering microscopy (Conference Presentation)

Dan Fu

Proceedings Volume PC12392, PC123920L (2023) https://doi.org/10.1117/12.2649567

KEYWORDS: Machine learning, Raman scattering, Microscopy, Tissues, Visualization, Signal to noise ratio, Proteins, Pathology, Mode conditioning cables, Imaging spectroscopy

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Proceedings Article | 6 March 2023 Presentation + Paper

Imaging protein aggregation in biopharmaceutical formulation with stimulated Raman scattering microscopy

Brian Wong, Xi Zhao, Yongchao Su, Dan Fu

Proceedings Volume 12368, 123680E (2023) https://doi.org/10.1117/12.2648675

KEYWORDS: Particles, Proteins, Image segmentation, Therapeutics, Raman spectroscopy, Raman scattering, Microscopy

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Proceedings Article | 27 May 2022 Presentation + Paper

Label-free classification of T-cell differentiation via deep learning of hyperspectral stimulated Raman scattering microscopy images

Bryce Manifold, Ruoqian Hu, Elisa Clark, Hao Yuan Kueh, Dan Fu

Proceedings Volume 12144, 1214406 (2022) https://doi.org/10.1117/12.2621455

KEYWORDS: Microscopy, Hyperspectral imaging, Lymphatic system, Raman scattering, Image classification, Microscopes, Tissues, Objectives, Modulation

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Proceedings Article | 2 March 2022 Presentation

Label-free multiphoton characterization of mouse brain cortical structures

Andrew Francis, Bryce Manifold, Elena Carlson, Ruoqian Hu, Andrew Hill, Shuaiqian Men, Dan Fu

Proceedings Volume PC11973, PC119730A (2022) https://doi.org/10.1117/12.2608995

KEYWORDS: Brain, Multiphoton microscopy, Microscopy, In vivo imaging, Capillaries, Brain mapping, Raman scattering, Proteins, Neurovascular coupling, Neuroimaging

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Proceedings Article | 2 March 2022 Presentation

Deep learning for analysis of hyperspectral stimulated Raman scattering images

Bryce Manifold, Dan Fu

Proceedings Volume PC11973, PC119730Y (2022) https://doi.org/10.1117/12.2609800

KEYWORDS: Raman scattering, Microscopy, Image segmentation, Hyperspectral imaging, Tissues, Mass spectrometry, Luminescence, Image classification

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Proceedings Article | 5 March 2021 Presentation

Imaging the structure and function of live mouse brain with multimodal nonlinear optical microscopy

Dan Fu

Proceedings Volume 11656, 116561D (2021) https://doi.org/10.1117/12.2577891

KEYWORDS: Brain, Optical microscopy, Neuroimaging, Microscopy, Luminescence, In vivo imaging, Axons, Two photon imaging, Temporal resolution, Raman scattering

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Proceedings Article | 22 August 2020 Presentation

Label-free chemical imaging of living biological samples at subcellular resolution

Dan Fu

Proceedings Volume 11497, 114970R (2020) https://doi.org/10.1117/12.2568208

KEYWORDS: Imaging spectroscopy, Image resolution, Chemical analysis, Microscopy, Biological research, Cancer, Neurodegeneration, Temporal resolution, Raman scattering, Mode conditioning cables

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Proceedings Article | 4 March 2019 Presentation

Imaging chemical and physical stability of drug formulations with stimulated Raman scattering microscopy (Conference Presentation)

Dan Fu

Proceedings Volume 10882, 108821O (2019) https://doi.org/10.1117/12.2510683

KEYWORDS: Microscopy, Imaging spectroscopy, Raman scattering, Solids, Crystals, Toxicity, Drug development, Temporal resolution

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Proceedings Article | 4 March 2019 Presentation

Hyperspectral stimulated Raman scattering imaging to determine spatially resolved chemical composition of breast calcifications in association with neoplastic processes (Conference Presentation)

Kseniya Shin, Mint Laohajaratsang, Suzanne Dintzis, Dan Fu

Proceedings Volume 10882, 1088221 (2019) https://doi.org/10.1117/12.2510732

KEYWORDS: Breast, Raman scattering, Mammography, Raman spectroscopy, Microscopy, Calcium, Breast cancer, Diagnostics, Biopsy, Hyperspectral imaging

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Proceedings Article | 4 March 2019 Paper

Broadband hyperspectral stimulated Raman scattering microscopy with a parabolic fiber amplifier source

Benjamin Figueroa, Walter Fu, Tai Nguyen, Kseniya Shin, Bryce Manifold, Frank Wise, Dan Fu

Proceedings Volume 10889, 1088910 (2019) https://doi.org/10.1117/12.2508104

KEYWORDS: Raman spectroscopy, Spectral resolution, Imaging systems, Fiber amplifiers, Microscopy, Imaging spectroscopy, Tissues, Raman scattering

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Proceedings Article | 9 February 2012 Paper

Towards a tunable fiber source for coherent Raman imaging

Simon Lefrancois, Dan Fu, Gary Holtom, Lingjie Kong, William Wadsworth, Patrick Schneider, Robert Herda, Armin Zach, X. Sunney Xie, Frank Wise

Proceedings Volume 8226, 822620 (2012) https://doi.org/10.1117/12.920187

KEYWORDS: Chromium, Picosecond phenomena, Fiber lasers, Microscopy, Dispersion, Coherence imaging, Raman spectroscopy, Four wave mixing, Fiber amplifiers, Tissues

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Proceedings Article | 23 February 2011 Paper

Sagnac-interferometry-based digital optical phase conjugation (DOPC) system for turbidity suppression

Timothy Hillman, YongKeun Park, Zahid Yaqoob, Wonshik Choi, Dan Fu, Toyohiko Yamauchi, Ramachandra Dasari, Michael Feld

Proceedings Volume 7904, 790417 (2011) https://doi.org/10.1117/12.875918

KEYWORDS: Spatial light modulators, Phase conjugation, Scattering, Tissue optics, Light scattering, Optical proximity correction, Laser scattering, Multiple scattering, Mirrors, Wave propagation

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Proceedings Article | 23 February 2011 Paper

Wide-field reflection phase microscope

Zahid Yaqoob, Toyohiko Yamauchi, Dan Fu, Wonshik Choi, Ramachandra Dasari, Michael Feld

Proceedings Volume 7904, 79040T (2011) https://doi.org/10.1117/12.875877

KEYWORDS: Microscopes, Reflection, Interferometry, Beam splitters, Optical coherence tomography, Phase imaging, Phase measurement, Diffraction gratings, Single mode fibers, Microscopy

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SPIE Journal Paper | 1 March 2010 Open Access

Static and dynamic light scattering of healthy and malaria-parasite invaded red blood cells

YongKeun Park, Monica Diez-Silva, Dan Fu, Gabriel Popescu, Wonshik Choi, Ishan Barman, Subra Suresh, Michael Feld

JBO, Vol. 15, Issue 02, 020506, (March 2010) https://doi.org/10.1117/12.10.1117/1.3369966

KEYWORDS: Light scattering, Scattering, Dynamic light scattering, Blood, Spectroscopy, Microscopy, Fourier transforms, Optical testing, Laser scattering, Scatter measurement

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Proceedings Article | 25 February 2009 Paper

Enhancing two-color absorption, self-phase modulation, and Raman microscopy signatures in tissue with femtosecond laser pulse shaping

Martin Fischer, Ivan Piletic, Dan Fu, Thomas Matthews, Henry Liu, Prathyush Samineni, Baolei Li, Warren Warren

Proceedings Volume 7183, 71830V (2009) https://doi.org/10.1117/12.816488

KEYWORDS: Absorption, Raman spectroscopy, Scanning probe microscopy, Modulation, Oscillators, Tumors, Luminescence, Tissues, Microscopy, Pulse shaping

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SPIE Journal Paper | 1 September 2008 Open Access

Probing skin pigmentation changes with transient absorption imaging of eumelanin and pheomelanin

Dan Fu, Tong Ye, Thomas Matthews, James Grichnik, Lian Hong, John Simon, Warren Warren

JBO, Vol. 13, Issue 05, 054036, (September 2008) https://doi.org/10.1117/12.10.1117/1.2976424

KEYWORDS: Skin, Absorption, Melanoma, Tissues, Signal to noise ratio, Phase shift keying, Thermal effects, Modulation, Laser beam diagnostics, Photothermal effect

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SPIE Journal Paper | 1 July 2008 Open Access

Label-free in vivo optical imaging of microvasculature and oxygenation level

Dan Fu, Thomas Matthews, Tong Ye, Ivan Piletic, Warren Warren

JBO, Vol. 13, Issue 04, 040503, (July 2008) https://doi.org/10.1117/12.10.1117/1.2968260

KEYWORDS: Blood vessels, Absorption, Tumors, Ear, In vivo imaging, Tissues, Laser scanners, Signal to noise ratio, Optical imaging, Hypoxia

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Proceedings Article | 15 February 2008 Paper

Label free high resolution in vivo optical imaging of microvessels

Dan Fu, Thomas Matthews, Tong Ye, Warren Warren

Proceedings Volume 6860, 68601Q (2008) https://doi.org/10.1117/12.763969

KEYWORDS: Absorption, Blood vessels, Ear, In vivo imaging, Tissues, Blood, Image resolution, Tumors, Signal to noise ratio, Laser scanners

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Proceedings Article | 8 February 2008 Paper

Two-photon absorption and transient photothermal imaging of pigments in tissues

Tong Ye, Dan Fu, Thomas Matthews, Lian Hong, John Simon, Warren Warren

Proceedings Volume 6842, 684206 (2008) https://doi.org/10.1117/12.764248

KEYWORDS: Absorption, Skin, Tissues, Picosecond phenomena, Phase shift keying, Modulation, Melanoma, Beam splitters, Microscopes, In vivo imaging

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SPIE Journal Paper | 1 September 2007 Open Access

Two-color, two-photon, and excited-state absorption microscopy

Dan Fu, Tong Ye, Thomas Matthews, Gunay Yurtsever, Warren Warren

JBO, Vol. 12, Issue 05, 054004, (September 2007) https://doi.org/10.1117/12.10.1117/1.2780173

KEYWORDS: Absorption, Modulation, Microscopy, Melanoma, Nonlinear optics, Luminescence, Laser beam diagnostics, Spectroscopy, Pulsed laser operation, Signal processing

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