Daniel Razansky is Full Professor of Biomedical Imaging at the University and ETH Zurich. He earned his degrees in Electrical and Biomedical Engineering from the Technion - Israel Institute of Technology and completed postdoctoral training in bio-optics at the Harvard Medical School. He was previously Professor of Molecular Imaging Engineering at the Technical University of Munich and Director of the Laboratory for Multi-Scale Functional and Molecular Imaging at the Helmholtz Center Munich. Prof. Razansky is the inventor of a number of new bio-imaging techniques, which have been successfully commercialized worldwide, among them the multi-spectral optoacoustic tomography (MSOT) and hybrid optoacoustic ultrasound (OPUS). He has authored over 200 peer-review journal articles and holds 12 inventions in bio-imaging and bio-sensing disciplines. His laboratory is supported by multiple grants from the ERC, NIH, HFSP, DFG and industrial collaborators. Prof. Razansky has delivered more than 100 invited, plenary and keynote talks and participates on a number of editorial boards of journals published by the Nature Publishing Group, Elsevier, IEEE, the American Association of Physicists in Medicine. He is frequently organizing and chairing international conferences of the SPIE, OSA, WMIC and IEEE.
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Optimization of light and sound delivery for in vivo whole-brain optoacoustic angiography of rodents
Real-time three-dimensional temperature mapping in photothermal therapy with optoacoustic tomography
Here we present a Weighted Synthetic Aperture Focusing Technique (W-SAFT) as a universal framework that effectively accounts for the non-uniform distribution of both the excitation light field and spatial sensitivity field of the detector. As a result, W-SAFT maintains optical resolution performance at superficial depths while improving the acoustic resolving capacity for deeper tissues. The dynamic range of the optoacoustic data is compressed using a general fluence decay term applied to the W-SAFT operator, allowing a more uniform visualization of the entire imaged volume. Our three-dimensional algorithm makes use of the sample's surface to account for the heterogeneity produced when scanning a finite-size light beam. We tested a GPU implementation of W-SAFT with numerical simulations and showcase its performance on experimental data acquired from targets embedded in tissue mimicking phantoms.
Here the insertion loss of murine skull has been measured by means of a hybrid optoacoustic-ultrasound scanning microscope having a spherically focused PVDF transducer and pulsed laser excitation at 532 nm of a 20 μm diameter absorbing microsphere acting as an optoacoustic point source. Accurate modeling of the acoustic transmission through the skull is further performed using a Fourier-domain expansion of a solid-plate model, based on the simultaneously acquired pulse-echo ultrasound image providing precise information about the skull's position and its orientation relative to the optoacoustic source. Good qualitative agreement has been found between the a solid-plate model and experimental measurements.
The presented strategy might pave the way for modeling skull effects and deriving efficient correction schemes to account for acoustic distortions introduced by an adult murine skull, thus improving the spatial resolution, effective penetration depth and overall image quality of transcranial optoacoustic brain microscopy.
Modeling the shape of cylindrically focused transducers in three-dimensional optoacoustic tomography
Modeling the shape of cylindrically focused transducers in three-dimensional optoacoustic tomography
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