Dr. Darren Lockie Profile

Dr. Darren Lockie

at BreastScreen Victoria

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Publications (4)

Proceedings Article | 4 April 2022 Poster + Paper

Energy optimisation of propagation-based phase-contrast computed tomography: a quantitative image quality assessment

Belinda Lim, Sarah Lewis, Benedicta Arhatari, Yakov Nesterets, Sheridan Mayo, Darren Thomposon, Jane Fox, Beena Kumar, Daniel Hausermann, Anton Maksimenko, Christopher Hall, Matthew Dimmock, Darren Lockie, Mary Rickard, Nicola Giannotti, Andrew Peele, Harry Quiney, Timur Gureyev, Patrick Brennan, SeyedamirTavakoli Taba

Proceedings Volume 12031, 120313O (2022) https://doi.org/10.1117/12.2608596

KEYWORDS: Image quality, X-rays, Breast, Signal to noise ratio, X-ray imaging, Quality measurement, Visualization, Visibility, Phase contrast

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SPIE Journal Paper | 12 July 2021

Effect of x-ray energy on the radiological image quality in propagation-based phase-contrast computed tomography of the breast

Sarina Wan, Benedicta Arhatari, Yakov Nesterets, Sheridan Mayo, Darren Thompson, Jane Fox, Beena Kumar, Zdenka Prodanovic, Daniel Hausermann, Anton Maksimenko, Christopher Hall, Matthew Dimmock, Konstantin Pavlov, Darren Lockie, Mary Rickard, Ziba Gandomkar, Alaleh Alaleh, Elham Vafa, Andrew Peele, Harry Quiney, Sarah Lewis, Timur Gureyev, Patrick Brennan, Seyedamir Tavakoli Taba

JMI, Vol. 8, Issue 05, 052108, (July 2021) https://doi.org/10.1117/12.10.1117/1.JMI.8.5.052108

KEYWORDS: Image quality, X-rays, X-ray imaging, Breast, Sensors, Breast cancer, Tissues, Radio propagation, X-ray detectors, X-ray computed tomography

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Purpose: Breast cancer is the most common cancer in women in developing and developed countries and is responsible for 15% of women’s cancer deaths worldwide. Conventional absorption-based breast imaging techniques lack sufficient contrast for comprehensive diagnosis. Propagation-based phase-contrast computed tomography (PB-CT) is a developing technique that exploits a more contrast-sensitive property of x-rays: x-ray refraction. X-ray absorption, refraction, and contrast-to-noise in the corresponding images depend on the x-ray energy used, for the same/fixed radiation dose. The aim of this paper is to explore the relationship between x-ray energy and radiological image quality in PB-CT imaging. Approach: Thirty-nine mastectomy samples were scanned at the imaging and medical beamline at the Australian Synchrotron. Samples were scanned at various x-ray energies of 26, 28, 30, 32, 34, and 60 keV using a Hamamatsu Flat Panel detector at the same object-to-detector distance of 6 m and mean glandular dose of 4 mGy. A total of 132 image sets were produced for analysis. Seven observers rated PB-CT images against absorption-based CT (AB-CT) images of the same samples on a five-point scale. A visual grading characteristics (VGC) study was used to determine the difference in image quality. Results: PB-CT images produced at 28, 30, 32, and 34 keV x-ray energies demonstrated statistically significant higher image quality than reference AB-CT images. The optimum x-ray energy, 30 keV, displayed the largest area under the curve ( AUCVGC ) of 0.754 (p = 0.009). This was followed by 32 keV (AUCVGC = 0.731, p ≤ 0.001), 34 keV (AUCVGC = 0.723, p ≤ 0.001), and 28 keV (AUCVGC = 0.654, p = 0.015). Conclusions: An optimum energy range (around 30 keV) in the PB-CT technique allows for higher image quality at a dose comparable to conventional mammographic techniques. This results in improved radiological image quality compared with conventional techniques, which may ultimately lead to higher diagnostic efficacy and a reduction in breast cancer mortalities.

Proceedings Article | 22 May 2020 Paper

Comparison of propagation-based phase-contrast CT and absorption-based CT for breast imaging using synchrotron radiation

Seyedamir Tavakoli Taba, Sarah Lewis, Patrycja Baran, Benedicta Arhatari, Yakov Nesterets, Sheridan Mayo, Darren Thompson, Jane Fox, Beena Kumar, Zdenka Prodanovic, Daniel Hausermann, Anton Maksimenko, Christopher Hall, Matthew Dimmock, Konstantin Pavlov, Andrew Peele, Harry Quiney, Darren Lockie, Giuliana Tromba, Timur Gureyev, Patrick Brennan

Proceedings Volume 11513, 115130T (2020) https://doi.org/10.1117/12.2564053

KEYWORDS: Phase contrast, Image quality, Breast, X-ray computed tomography, X-rays, Tissues, Synchrotrons, Visualization, Breast imaging, Synchrotron radiation, X-ray imaging

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Proceedings Article | 6 July 2018 Paper

Towards clinic-friendly solutions for patient trials in breast cancer phase contrast imaging

Sarah Lewis, Timur Gureyev, Patrycja Baran, Seyedamir Tavakoli Taba, Serena Pacile, Christian Dullin, Giuliana Tromba, Daniel Hausermann, Andrew Peele, Darren Lockie, Patrick Brennan

Proceedings Volume 10718, 107181P (2018) https://doi.org/10.1117/12.2316498

KEYWORDS: Breast, Breast cancer, Mammography, Cancer, Sensors, Synchrotrons, X-rays, X-ray imaging, Tissues

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