This study reports the results of our recent in vivo study using attenuation-based quantitative OCT for intra-operative mapping of brain cancer in patients. A total of 34 brain cancer patients were recruited, and an optimal optical attenuation threshold of 4.3 mm-1 was established with cancer of lower values. We achieved an excellent specificity of over 98%, with a corresponding sensitivity of over 95% for both high-grade and low-grade cancers. Applying the established optical attenuation threshold to infiltrated tissues, we were able to identify regions of cancers qualitatively matching the neuropathologist’s assessment. The study suggests that optical attenuation-based quantitative OCT represents a promising technology for intraoperative brain cancer detection and
High-resolution imaging technologies, such as multiphoton imaging (MPM) and optical coherence tomography (OCT), are capable of high-speed imaging of biological tissues in vivo with subcellular resolution. In brain cancer surgery, it is challenging to distinguish cancer from noncancer intraoperatively. This study shows that MPM can provide label-free images with histological details. Increased cellularity, microvascular proliferation, nuclear pleomorphism and collagen deposition, can be clearly visualized in cancerous human brain tissues. Photodynamic therapy (PDT) is an effective treatment for cancers. The change of tumor vasculatures, including a newly-formed microvascular, in response to PDT, is a key assessment parameter for optimizing the treatment effect. We demonstrated the in vivo imaging of PDT effects on mouse tumor model with an ultrahigh-resolution functional OCT. The technologies have shown significant translational potential for cancer detection and PDT treatment assessment.
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