Dr. Dirk U. Näther Profile

Dr. Dirk U. Näther

Senior Scientist at Edinburgh Instruments Ltd

SPIE Involvement:

Author

Publications (6)

Proceedings Article | 17 February 2010 Paper

The supercontinuum laser as a flexible source for quasi-steady state and time resolved fluorescence studies

Roger Fenske, Dirk Näther, Richard Dennis, S. Desmond Smith

Proceedings Volume 7580, 75800R (2010) https://doi.org/10.1117/12.842672

KEYWORDS: Luminescence, Supercontinuum sources, Dispersion, Light sources, Interference filters, Optical filters, Spectrometers, Sensors, Electronics, Photons

Read Abstract +

Proceedings Article | 3 November 2006 Paper

Dirk Näther, Roger Fenske, Reynald Hurteaux, Sandra Majno, S. Smith

Proceedings Volume 6372, 637208 (2006) https://doi.org/10.1117/12.688419

KEYWORDS: Luminescence, Single photon, Fluorescence resonance energy transfer, Data acquisition, Fluorescence anisotropy, Diffusion, Confocal microscopy, Anisotropy, Molecules, Time metrology

Read Abstract +

Proceedings Article | 25 October 2006 Paper

New light sources for time-correlated single photon counting in commercially available spectrometers

Roger Fenske, Dirk Näther, Mark Goossens, S. Smith

Proceedings Volume 6372, 63720H (2006) https://doi.org/10.1117/12.688421

KEYWORDS: Light sources, Luminescence, Spectrometers, Picosecond phenomena, Semiconductor lasers, Pulsed laser operation, Single photon, Photonic crystal fibers, Dispersion, Sapphire lasers

Read Abstract +

Proceedings Article | 17 June 1993 Paper

Photophysical properties of protein conjugates with PDT photosensitizers

Alexander Savitsky, K. Lopatin, Oleg Lobanov, N. Golubeva, Marina Poroshina, Elena Chernyaeva, L. Solovieva, Eugeny Lukyanets, Maria Galpern, B. Roder, Dirk Nather

Proceedings Volume 1922, (1993) https://doi.org/10.1117/12.146207

KEYWORDS: Luminescence, Proteins, Absorption, Molecules, Absorbance, Photodynamic therapy, Monoclonal antibodies, Sodium, Aluminum, Chlorine

Read Abstract +

Photodynamic therapy (PDT) of malignant tumors is based on the property of some photosensitizers to be accumulated by tumour tissues'. On subsequent illumination with light of the wavelength absorbed by these photosensitizers tumour cells can be destroyed. Hematoporphyrin derivative and similar agents presently have some negative features. First, these agents do not possess optimal absorption spectrum. In particular the absorbance in the red region is not very high. Second, the composition of these agents varies for different preparations and with the storage time. Third, they do not possess a sufficient selectivity for malignant cells. Furthermore, they are also accumulated in skin causing its damage upon exposure to light. Thus at present the developing of the effective PDT photosensitizers is of great interest. Recently some of this interest has been focussed on the phthalocyanines (PC). These dyes have sufficient molar extinction coefficient (<10 M1cm1) in red region of optical spectrum (650 700 nm). They are non-toxic. Some of them are effective photosensitizers and produce singlet oxygen. They are relatively easy synthesized and resistant to chemical degradation. PC can have different groups added to the external macrocycle perifery. These groups mainly determine chemical properties and solubility. They offer possibility to bind the dyes to any other molecules, for example, proteins. The properties of naphthalocyanines (NC) are rather similar to the ones of PC, but the most efficient absorption band is in region of 750 - 800 nm. An important problem is to increase the ratio between the level of photosensitizer in malignant and normal tissues. One of the possible solutions is the use of photoimmunotoxins, i.e. conjugates of photosensitizers with monoclonal antibodies (mAb) against cancer antigens or tumor marker. Experiments with immunoglobulin-hematoporphyrin2 and dimetoxyhematoporphyrin3 as well as chiorin e6 conjugates4 showed that they retained both photochemical properties of free dyes and immunological ones of antibodies.

Proceedings Article | 18 May 1993 Paper

Temporal and spectral separation of singlet oxygen luminescence from near-infrared emitting photosensitizers

John Gilchrist, Dirk Nather

Proceedings Volume 1885, (1993) https://doi.org/10.1117/12.144726

KEYWORDS: Oxygen, Luminescence, Near infrared, Spectroscopy, Sensors, Infrared spectroscopy, Time metrology, Molecules, Pulsed laser operation, Bioalcohols

Read Abstract +

Proceedings Article | 1 November 1991 Paper

Characterization of photobiophysical properties of sensitizers used in photodynamic therapy

Beate Roeder, Dirk Nather

Proceedings Volume 1525, (1991) https://doi.org/10.1117/12.48194

KEYWORDS: Oxygen, Quantum efficiency, Molecules, Photodynamic therapy, Biomedical optics, Luminescence, Metals, Molecular lasers, Aluminum, Energy transfer

Read Abstract +

Showing 5 of 6 publications

View contact details

UPDATE YOUR PROFILE

Is this your profile? Update it now.

Sign into your SPIE.org account

Don’t have a profile and want one?

Create an account on SPIE.org

Keywords/Phrases

Search In:

Publication Years