Dr. Douglas J. Moseley Profile

Dr. Douglas J. Moseley

Assistant Professor at Ontario Cancer Institute

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Publications (11)

Proceedings Article | 21 March 2007 Paper

Multimode C-arm fluoroscopy, tomosynthesis, and cone-beam CT for image-guided interventions: from proof of principle to patient protocols

J. Siewerdsen, M. Daly, G. Bachar, D. Moseley, G. Bootsma, K. Brock, S. Ansell, G. Wilson, S. Chhabra, D. Jaffray, J. Irish

Proceedings Volume 6510, 65101A (2007) https://doi.org/10.1117/12.713642

KEYWORDS: Surgery, Image-guided intervention, Image quality, Visualization, Imaging systems, Computed tomography, X-ray computed tomography, Head, Sensors, Stereoscopy

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Proceedings Article | 6 March 2006 Paper

Scatter correction for kilovoltage cone-beam computed tomography (CBCT) images using Monte Carlo simulations

G. Jarry, S. Graham, D. Jaffray, D. Moseley, F. Verhaegen

Proceedings Volume 6142, 614254 (2006) https://doi.org/10.1117/12.653803

KEYWORDS: Monte Carlo methods, Particles, Sensors, Computer simulations, Solids, Signal to noise ratio, Signal detection, X-rays, Head, Smoothing

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Proceedings Article | 2 March 2006 Paper

High-performance dual-energy imaging with a flat-panel detector: imaging physics from blackboard to benchtop to bedside

J. Siewerdsen, N. Shkumat, A. Dhanantwari, D. Williams, S. Richard, M. Daly, N. Paul, D. Moseley, D. Jaffray, J. Yorkston, R. Van Metter

Proceedings Volume 6142, 61421E (2006) https://doi.org/10.1117/12.658080

KEYWORDS: Imaging systems, Sensors, Image acquisition, Oximeters, Dual energy imaging, Lung, Radiography, Diagnostics, Silver, X-rays

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The application of high-performance flat-panel detectors (FPDs) to dual-energy (DE) imaging offers the potential for dramatically improved detection and characterization of subtle lesions through reduction of "anatomical noise," with applications ranging from thoracic imaging to image-guided interventions. In this work, we investigate DE imaging performance from first principles of image science to preclinical implementation, including: 1.) generalized task-based formulation of NEQ and detectability as a guide to system optimization; 2.) measurements of imaging performance on a DE imaging benchtop; and 3.) a preclinical system developed in our laboratory for cardiac-gated DE chest imaging in a research cohort of 160 patients. Theoretical and benchtop studies directly guide clinical implementation, including the advantages of double-shot versus single-shot DE imaging, the value of differential added filtration between low- and high-kVp projections, and optimal selection of kVp pairs, filtration, and dose allocation. Evaluation of task-based NEQ indicates that the detectability of subtle lung nodules in double-shot DE imaging can exceed that of single-shot DE imaging by a factor of 4 or greater. Filter materials are investigated that not only harden the high-kVp beam (e.g., Cu or Ag) but also soften the low-kVp beam (e.g., Ce or Gd), leading to significantly increased contrast in DE images. A preclinical imaging system suitable for human studies has been constructed based upon insights gained from these theoretical and experimental studies. An important component of the system is a simple and robust means of cardiac-gated DE image acquisition, implemented here using a fingertip pulse oximeter. Timing schemes that provide cardiac-gated image acquisition on the same or successive heartbeats is described. Preclinical DE images to be acquired under research protocol will afford valuable testing of optimal deployment, facilitate the development of DE CAD, and support comparison of DE diagnostic imaging performance to low-dose CT and radiography.

Proceedings Article | 28 February 2006 Paper

Guidance for cone-beam CT design: tradeoff between view sampling rate and completeness of scanning trajectories

Guang-Hong Chen, Jeffrey Siewerdsen, Shuai Leng, Douglas Moseley, Brian Nett, Jiang Hsieh, David Jaffray, C. Mistretta

Proceedings Volume 6142, 614212 (2006) https://doi.org/10.1117/12.653174

KEYWORDS: Reconstruction algorithms, Sensors, X-ray computed tomography, Numerical simulations, Image restoration, X-rays, Computed tomography, Data acquisition, X-ray imaging, X-ray detectors

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SPIE Journal Paper | 1 May 2005 Open Access

Photodynamic therapy for the treatment of metastatic lesions in bone: Studies in rat and porcine models

Shane Burch, Arjun Bogaards, Jeffrey Siewerdsen, Douglas Moseley, Albert Yee, J. Finkelstein, Robert Weersink, Brian Wilson, Stuart Bisland

JBO, Vol. 10, Issue 03, 034011, (May 2005) https://doi.org/10.1117/12.10.1117/1.1921887

KEYWORDS: Photodynamic therapy, Bone, Tumors, Spine, Spinal cord, Tissues, Tumor growth modeling, Breast cancer, Bioluminescence, Cancer

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Proceedings Article | 20 April 2005 Paper

High-contrast object localization and removal in cone-beam CT

D. Moseley, J. Siewerdsen, D. Jaffray

Proceedings Volume 5745, (2005) https://doi.org/10.1117/12.595766

KEYWORDS: Neodymium, Sensors, X-ray computed tomography, Prostate, Reconstruction algorithms, Computed tomography, Calibration, Gold, Computing systems, Radiotherapy

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Proceedings Article | 20 April 2005 Paper

Generalized DQE analysis of dual-energy imaging using flat-panel detectors

S. Richard, J. Siewerdsen, D. Jaffray, D. Moseley, B. Bakhtiar

Proceedings Volume 5745, (2005) https://doi.org/10.1117/12.595534

KEYWORDS: Imaging systems, Tissues, Sensors, Quantum efficiency, Spatial frequencies, Dual energy imaging, Chest, Modulation transfer functions, Image processing, Quantum electronics

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Proceedings Article | 20 April 2005 Paper

Achieving high-resolution soft-tissue imaging with cone-beam CT: a two-pronged approach for modulation of x-ray fluence and detector gain

S. Graham, J. Siewerdsen, D. Moseley, H. Keller, N. Shkumat, D. Jaffray

Proceedings Volume 5745, (2005) https://doi.org/10.1117/12.595886

KEYWORDS: Sensors, Modulation, Head, X-rays, X-ray computed tomography, Image filtering, X-ray detectors, X-ray imaging, Liver, Visualization

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Proceedings Article | 12 April 2005 Paper

Cone-beam CT with a flat-panel detector on a mobile C-arm: preclinical investigation in image-guided surgery of the head and neck

J. Siewerdsen, Y. Chan, M. Rafferty, D. Moseley, D. Jaffray, J. Irish

Proceedings Volume 5744, (2005) https://doi.org/10.1117/12.595690

KEYWORDS: Surgery, Skull, Head, Endoscopy, Neck, Computed tomography, Image-guided intervention, Sensors, Imaging systems, Tissues

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Proceedings Article | 14 June 2004 Paper

Photodynamic therapy for the treatment of metastatic lesions in bone: studies in rat and porcine models

S. Burch, Stuart Bisland, Jeff Siewerdsen, Arjen Bogaards, Douglas Moseley, A. Yee, J. Finkelstein, Brian Wilson

Proceedings Volume 5315, (2004) https://doi.org/10.1117/12.548174

KEYWORDS: Photodynamic therapy, Bone, Tumors, Spine, Spinal cord, Sensors, Breast cancer, Tissues, Control systems, Animal model studies

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Proceedings Article | 6 May 2004 Paper

Incorporation of task in 3D imaging performance evaluation: the impact of asymmetric NPS on detectability

Jeff Siewerdsen, Douglas Moseley, David Jaffray

Proceedings Volume 5368, (2004) https://doi.org/10.1117/12.535744

KEYWORDS: Optical spheres, Imaging systems, 3D modeling, 3D image processing, Stereoscopy, Computed tomography, Signal to noise ratio, Sensors, Interference (communication), Image filtering

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While analysis of the image noise-power spectrum (NPS) and noise-equivalent quanta (NEQ) are important aspects of imaging system characterization, such metrics are in themselves insufficient descriptions of imaging performance in that they make no account of the imaging task. This paper seeks to quantitatively incorporate imaging task in imaging performance evaluation by combining NEQ with a variety of idealized spatial-frequency-dependent task functions to yield the model observer detectability index. The approach is applied to the case of fully 3D volumetric imaging by flat-panel detector cone-beam CT through analysis of 3D detectability for conditions of varying dose, reconstruction filter, and voxel size. Generalization of the NEQ through incorporation of background "anatomical" noise suggests significant degradation in model observer performance, and the effect is quantified for a variety of detection and discrimination tasks. For anatomical noise modeled according to 1/f b statistics in power-spectral density, the effect is shown to be most severe for low-frequency detection tasks, and somewhat less for mid-to-high spatial frequency tasks, such as discrimination and localization. By considering the fully 3D NEQ, which is known to be asymmetric for cone-beam CT, a compelling hypothesis is realized regarding the detection of structures in volumetric CT images - specifically, that the detectability is different in axial versus sagittal / coronal domains due to asymmetry in the NEQ between these domains, compared to the case in which 3D data are fully interrogated (e.g., by a machine algorithm). This has significant implications for 3-D imaging modalities, including flat-panel cone-beam CT, where the NPS exhibits asymmetric frequency characteristics [viz., high-pass (filtered-ramp) in the transverse domain and low-pass in the longitudinal]. The impact of asymmetric NPS characteristics on detectability was investigated by analysis of the 3D detectability for imaging tasks corresponding to detection and discrimination of fine and low-contrast structures.

Showing 5 of 11 publications

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