Mr. Duan Shu Profile

Duan Shu

at Britton Chance Ctr for Biomedical Photonics

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Proceedings Article | 9 November 2010 Paper

Quantitative analysis of dehydration in porcine skin caused by optical clearing agents

Tingting Yu, Xiang Wen, Shu Duan, Dan Zhu

Proceedings Volume 7845, 78450L (2010) https://doi.org/10.1117/12.871755

KEYWORDS: Skin, Optical clearing, Scattering, Reflectivity, Water, Transmittance, Calibration, Statistical modeling, Quantitative analysis, Tissue optics

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Dehydration is supposed to be one of mechanisms of optical clearing, but current studies merely gave some qualitative descriptions. Here an analysis method was established to evaluate the water content of skin with PLS method based on the measurements of near-infrared reflectance spectroscopy and weight of porcine skin. Furthermore, a commercial spectrometer with integrating sphere was used to measure the reflectance and transmittance after treatment with different agents. Then the established method was used to evaluate the water content, while the Inverse Adding-Double algorithm was used to calculate the reduced scattering coefficients. The results show that both the water contents and reduced scattering coefficients decrease during the optical clearing process, and there is direct relationship between the optical clearing efficacy and dehydration. With the treating time last, the relative change in reduced scattering coefficient is larger than that in dehydration of skin, and the difference between the changes depends on the agents. Therefore, we conclude that dehydration is the main mechanism of skin optical clearing during the 60 min treatment of the agents, but for some OCAs, i.e., PEG400, glycerol, or D-sorbitol, there might be some other mechanisms contributing to the optical clearing efficacy.

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