Dr. Ehsan Vaghefi Profile

Dr. Ehsan Vaghefi

at Univ of Auckland

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Proceedings Article | 28 February 2020 Paper

Repeatability, reproducibility, and accuracy of a novel imaging technique for measurement of ocular axial length

Neelam Hari, Carrie Burgess, Ehsan Vaghefi

Proceedings Volume 11317, 113172D (2020) https://doi.org/10.1117/12.2560544

KEYWORDS: Eye, Eye models, Animal model studies, Magnetic resonance imaging, Image acquisition, Cornea, Tissues, Statistical analysis, Laser safety

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The rise in short-sightedness (myopia) is raising concerns in our global health, impacting an estimated 22.9% of the world’s population in the year 2000.1, 2 We are developing a new method to determine axial length measurements of the eye, addressing the paediatric population. The purpose of this study is to assess the repeatability, reproducibility, and accuracy of our proposed imaging technique for axial length measurements in ex vivo animal eyes and human model eyes. Our non-contact optical system utilizes an 808 nm continuous wave laser. For the animal study, our system employed varying laser powers <0.6 mW, obtaining images of ex vivo porcine eyes. Comparative measurements were taken with MRI of the same samples in similar conditions. Results indicated that our system was both repeatable and reproducible. The trend for accuracy was not evident in animal eyes, but this was due to the variable ex vivo sample quality. For the model eye study, and to mimic clinical conditions, the laser intensity is reduced via optical components resulting in a safe exposure for the human eye, as outlined by IEC 60825-1:2014. This laser exposure includes a beam power of <0.4 mW and exposure time of less than 2 seconds. Data is captured with an infrared camera. Our device will offer a unique and low-cost solution for early detection of myopia in children, helping to timely intervene and ultimately control the looming myopia pandemic.

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