Dr. Elicia M. Kohlenberg Profile

Dr. Elicia M. Kohlenberg

at National Research Council Canada

SPIE Involvement:

Author

Publications (8)

Proceedings Article | 23 February 2011 Paper

Using multimodal femtosecond CARS imaging to determine plaque burden in luminal atherosclerosis

Alex C-T. Ko, Leila Mostaço-Guidolin, Andrew Ridsdale, Adrian Pegoraro, Michael S. Smith, Aaron Slepkov, Mark Hewko, Elicia Kohlenberg, Bernie Schattka, Albert Stolow, Michael Sowa

Proceedings Volume 7903, 790318 (2011) https://doi.org/10.1117/12.873867

KEYWORDS: Second-harmonic generation, Collagen, Femtosecond phenomena, CARS tomography, Arteries, Tissues, Image analysis, Microscopes, Microscopy, Statistical analysis

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SPIE Journal Paper | 1 March 2010 Open Access

Multimodal nonlinear optical imaging of atherosclerotic plaque development in myocardial infarction-prone rabbits

Alex Ko, Andrew Ridsdale, Michael Smith, Leila Mostaço-Guidolin, Mark Hewko, Adrian Pegoraro, Elicia Kohlenberg, Bernhard Schattka, Masashi Shiomi, Albert Stolow, Michael Sowa

JBO, Vol. 15, Issue 02, 020501, (March 2010) https://doi.org/10.1117/12.10.1117/1.3353960

KEYWORDS: Collagen, Microscopes, Femtosecond phenomena, Nonlinear optics, Tissues, CARS tomography, Objectives, Multimodal imaging, Optical imaging, Tissue optics

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Proceedings Article | 24 February 2009 Paper

Label-free imaging of arterial tissues using photonic crystal fiber (PCF) based nonlinear optical microscopic system

Alex C. Ko, Andrew Ridsdale, Adrian Pegoraro, Michael S. Smith, Leila Mostaço-Guidolin, Mark Hewko, Elicia Kohlenberg, Bernie Schattka, Masashi Shiomi, Albert Stolow, Michael Sowa

Proceedings Volume 7182, 718204 (2009) https://doi.org/10.1117/12.809361

KEYWORDS: Tissues, Imaging systems, Collagen, Microscopes, Nonlinear optics, Photonic crystal fibers, Natural surfaces, Second-harmonic generation, Objectives, Complex systems

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Proceedings Article | 23 March 2007 Paper

Broadband coherent anti-Stokes Raman scattering (CARS): a potential tool for atherosclerosis diagnostic imaging

J.-F. Cormier, A. Ko, L.-P. Choo-Smith, J. Werner, E. Kohlenberg, M. Hewko, J. Fréchette, M. Fortin, I. Noiseux, J. P. Bouchard, David Gay, P. Desroches, Francois Roy-Moisan, Marie-Eve Bourgault, M. Sowa, M. Vernon

Proceedings Volume 6424, 64241X (2007) https://doi.org/10.1117/12.701243

KEYWORDS: Raman spectroscopy, Control systems, Tissues, CARS tomography, Arteries, Spectroscopy, Collagen, Luminescence, Principal component analysis, Molecules

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Proceedings Article | 22 February 2006 Paper

Atherosclerosis diagnostic imaging by optical spectroscopy and optical coherence tomography

M. D. Hewko, L. P. Choo-Smith, A. C. T. Ko, M. S. D. Smith, E. M. Kohlenberg, E. R. Bock, L. Leonardi, M. G. Sowa

Proceedings Volume 6078, 60782E (2006) https://doi.org/10.1117/12.641438

KEYWORDS: Raman spectroscopy, Collagen, Arteries, Optical coherence tomography, Tissues, Near infrared, Diagnostics, Luminescence, Imaging spectroscopy, Optical imaging

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Atherosclerosis is traditionally viewed as a disease of uncontrolled plaque growth leading to arterial occlusion. More recently, however, occlusion of the arterial lumen is being viewed as an acute event triggered by plaque rupture and thrombosis. An atheromatous plaque becomes vulnerable to sudden activation and/or rupture when a constellation of processes are activated by various trigger mechanisms. There is growing evidence that the vulnerability (i.e. susceptibility to rupture) and thrombogenic nature of the plaque need to be taken into account in the planning and treatment of the disease. X-ray fluoroscopy and intravascular ultrasound, the current clinical diagnostic tools are not capable of the providing a complete histological picture of the plaque region. Intravascular diagnostic imaging of coronary atherosclerotic plaques by optical means to assess plaque, patient risk and assist in planning treatment strategies represents the future in angioplasty treatment by interventional cardiologists. The techniques which will enable a clinically acceptable and reliable intravascular diagnostic platform are currently being investigated and compared to the clinical standard of histology. Currently, we are investigating the use of a number of optical and imaging techniques for biochemical analysis of arterial tissue including Raman, near infrared and fluorescence spectroscopies. Biochemical imaging will provide compositional information on collagen, elastin, lipid and thrombogenic by-products as well as gauging inflammation and tissue remodeling activity levels. To complement the functional biochemical imaging, optical coherence tomography will be provide structural morphological imaging. The synergistic combination of functional and structural imagery will provide the interventional cardiologist with a complete clinical picture of the atherosclerotic plaque region. The clinician can use this diagnostic information to plan a personalized treatment procedure based on the entire clinical presentation.

Proceedings Article | 14 October 2005 Paper

Spectroscopic detection of the blanch response at the heel of the foot: a possible diagnostic for stage I pressure ulcers

Elicia Kohlenberg, Jeanne Zanca, David Brienza, Michelle Levasseur, Michael Sowa

Proceedings Volume 5969, 59691J (2005) https://doi.org/10.1117/12.628219

KEYWORDS: Skin, Tissues, Data modeling, Spectroscopy, Electronic filtering, Tissue optics, Visible radiation, Reflectivity, Reflectance spectroscopy, Blood

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Proceedings Article | 13 October 2005 Paper

Near-infrared hyperspectral imaging: the road traveled to a clinical burn application

Michelle Levasseur, Lorenzo Leonardi, Jeri Payette, Elicia Kohlenberg, Michael Sowa, Joel Fish, Karen Cross, Manuel Gomez

Proceedings Volume 5969, 59691O (2005) https://doi.org/10.1117/12.628233

KEYWORDS: Near infrared, Injuries, Hyperspectral imaging, Imaging systems, Tissues, Control systems, Cameras, Blood, Oxygen, Hemodynamics

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Proceedings Article | 9 December 2004 Paper

Optical spectroscopic assessment of free flap circulatory impairment

Michael Sowa, Jeri Payette, Elicia Kohlenberg, Lorenzo Leonardi, Arone Pabbies, Paul Kerr

Proceedings Volume 5578, (2004) https://doi.org/10.1117/12.567434

KEYWORDS: Blood, Optical spectroscopy, Reflectivity, Tissues, Spectroscopy, Skin, Surgery, Tissue optics, Visible radiation, Animal model studies

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