Prof. Evgeny Katz Profile

Prof. Evgeny Katz

at Clarkson Univ

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SPIE Journal Paper | 15 September 2014

Role of biomolecular logic systems in biosensors and bioactuators

Shay Mailloux, Evgeny Katz

OE, Vol. 53, Issue 09, 097107, (September 2014) https://doi.org/10.1117/12.10.1117/1.OE.53.9.097107

KEYWORDS: Logic, Signal processing, Biological research, Biosensors, Chemical analysis, Electrodes, Logic devices, Biomedical optics, Computing systems, Absorbance

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An overview of recent advances in biosensors and bioactuators based on biocomputing systems is presented. Biosensors digitally process multiple biochemical signals through Boolean logic networks of coupled biomolecular reactions and produce an output in the form of a YES/NO response. Compared to traditional single-analyte sensing devices, the biocomputing approach enables high-fidelity multianalyte biosensing, which is particularly beneficial for biomedical applications. Multisignal digital biosensors thus promise advances in rapid diagnosis and treatment of diseases by processing complex patterns of physiological biomarkers. Specifically, they can provide timely detection and alert medical personnel of medical emergencies together with immediate therapeutic intervention. Application of the biocomputing concept has been successfully demonstrated for systems performing logic analysis of biomarkers corresponding to different injuries, particularly as exemplified for liver injury. Wide-ranging applications of multianalyte digital biosensors in medicine, environmental monitoring, and homeland security are anticipated. “Smart” bioactuators, for signal-triggered drug release, for example, were designed by interfacing switchable electrodes with biocomputing systems. Integration of biosensing and bioactuating systems with biomolecular information processing systems advances the potential for further scientific innovations and various practical applications.

Proceedings Article | 22 May 2014 Paper

Biomolecular logic systems: applications to biosensors and bioactuators

Evgeny Katz

Proceedings Volume 9107, 91070Z (2014) https://doi.org/10.1117/12.2049959

KEYWORDS: Logic, Signal processing, Biological research, Biosensors, Chemical analysis, Electrodes, Biomedical optics, Logic devices, Absorbance, Data processing

Read Abstract +

The paper presents an overview of recent advances in biosensors and bioactuators based on the biocomputing concept. Novel biosensors digitally process multiple biochemical signals through Boolean logic networks of coupled biomolecular reactions and produce output in the form of YES/NO response. Compared to traditional single-analyte sensing devices, biocomputing approach enables a high-fidelity multi-analyte biosensing, particularly beneficial for biomedical applications. Multi-signal digital biosensors thus promise advances in rapid diagnosis and treatment of diseases by processing complex patterns of physiological biomarkers. Specifically, they can provide timely detection and alert to medical emergencies, along with an immediate therapeutic intervention. Application of the biocomputing concept has been successfully demonstrated for systems performing logic analysis of biomarkers corresponding to different injuries, particularly exemplified for liver injury. Wide-ranging applications of multi-analyte digital biosensors in medicine, environmental monitoring and homeland security are anticipated. “Smart” bioactuators, for example for signal-triggered drug release, were designed by interfacing switchable electrodes and biocomputing systems. Integration of novel biosensing and bioactuating systems with the biomolecular information processing systems keeps promise for further scientific advances and numerous practical applications.

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