Dr. Frances S. Ligler Profile

Dr. Frances S. Ligler

Professor

SPIE Involvement:

Track Chair | Author

Publications (30)

SPIE Journal Paper | 14 August 2014 Open Access

Review of recent developments in stimulated emission depletion microscopy: applications on cell imaging

Bhanu Neupane, Frances Ligler, Gufeng Wang

JBO, Vol. 19, Issue 08, 080901, (August 2014) https://doi.org/10.1117/12.10.1117/1.JBO.19.8.080901

KEYWORDS: Stimulated emission depletion microscopy, Microscopy, Proteins, Microscopes, Image resolution, Luminescence, Confocal microscopy, Spatial resolution, Spine, Super resolution

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Proceedings Article | 1 February 2012 Paper

A microflow cytometer for optical analysis of phytoplankton

Joel Golden, Nastaran Hashemi, Jeffrey Erickson, Frances Ligler

Proceedings Volume 8212, 82120G (2012) https://doi.org/10.1117/12.905679

KEYWORDS: Optical fibers, Microfluidics, Luminescence, Light scattering, Optical analysis, Flow cytometry, Ocean optics, Analytical research, Biological detection systems, Oceanography

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Proceedings Article | 26 February 2010 Paper

A microflow cytometer on a chip

Joel Golden, Jason Kim, George Anderson, Nastaran Hashemi, Peter Howell, Frances Ligler

Proceedings Volume 7553, 755308 (2010) https://doi.org/10.1117/12.842623

KEYWORDS: Optical fibers, Lithography, Microfluidics, Sensors, Particles, Luminescence, Multiplexing, Optical analysis, Biological research, Bacteria

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Proceedings Article | 19 February 2009 Paper

Microflow cytometer

Frances Ligler, Jeffrey Erickson, Joel Golden, Jason Kim, Mansoor Nasir, Peter Howell, Abel Thangawng, Lisa Hilliard, George Anderson

Proceedings Volume 7167, 71670N (2009) https://doi.org/10.1117/12.807671

KEYWORDS: Optical fibers, Lithography, Microfluidics, Sensors, Particles, Luminescence, Diagnostics, Multiplexing, Pathogens, Neodymium

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Proceedings Article | 13 February 2008 Paper

Components for automated microfluidics sample preparation and analysis

M. Archer, J. Erickson, L. Hilliard, P. Howell, D. Stenger, F. Ligler, B. Lin

Proceedings Volume 6898, 68981C (2008) https://doi.org/10.1117/12.766492

KEYWORDS: Microfluidics, Statistical analysis, Ions, Silicon, Diffusion, Solids, Pathogens, Molecular biology, Analytical research, Dendrimers

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Proceedings Article | 7 December 2004 Paper

A portable array biosensor

Joel Golden, Lisa Shriver-Lake, Chris Taitt, Stephanie Fertig, Kim Sapsford, Fran Ligler

Proceedings Volume 5586, (2004) https://doi.org/10.1117/12.571310

KEYWORDS: Target detection, Statistical analysis, Waveguides, Luminescence, Biosensors, Control systems, Software development, Planar waveguides, Biological research, Data analysis

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Proceedings Article | 19 November 2004 Paper

A portable array biosensor for food safety

Joel Golden, Miriam Ngundi, Lisa Shriver-Lake, Chris Taitt, Frances Ligler

Proceedings Volume 5587, (2004) https://doi.org/10.1117/12.570285

KEYWORDS: Safety, Statistical analysis, Waveguides, Luminescence, Biosensors, Control systems, CCD cameras, Pathogens, Planar waveguides, Biological research

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Proceedings Article | 22 July 2003 Paper

An automated portable array biosensor

Joel Golden, Yura Shubin, Lisa Shriver-Lake, James Delehanty, Kim Sapsford, Chris Rowe-Taitt, Frances Ligler

Proceedings Volume 4958, (2003) https://doi.org/10.1117/12.485497

KEYWORDS: Defense and security, Safety, Statistical analysis, Waveguides, Sensors, Molecules, Biosensors, Pathogens, Receptors, Biological research

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SPIE Journal Paper | 1 October 2002 Open Access

Tools for Biomolecular and Cellular Analysis

Fran Ligler, Richard Thompson

JBO, Vol. 7, Issue 04, (October 2002) https://doi.org/10.1117/12.10.1117/1.1513562

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Proceedings Article | 22 February 2002 Paper

Array biosensor for environmental monitoring

Frances Ligler, K. Sapsford, Y. Shubin, J. Lemmond, Chris Rowe-Taitt, J. Delahanty, Joel Golden

Proceedings Volume 4576, (2002) https://doi.org/10.1117/12.456949

KEYWORDS: Environmental monitoring, Statistical analysis, Waveguides, Sensors, Luminescence, Biosensors, Planar waveguides, Biological research, Analytical research, CCD image sensors

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Proceedings Article | 10 May 2001 Paper

Array biosensor for simultaneous detection of multiple analytes

Frances Ligler, Joel Golden, Chris Rowe-Taitt, James Dodson

Proceedings Volume 4252, (2001) https://doi.org/10.1117/12.426740

KEYWORDS: Statistical analysis, Waveguides, Cladding, Sensors, Luminescence, Molecules, Silver, Biosensors, Biological research, Analytical research

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Proceedings Article | 3 May 1999 Paper

Array biosensor: recent developments

Joel Golden, Chris Rowe-Taitt, Mark Feldstein, Frances Ligler

Proceedings Volume 3602, (1999) https://doi.org/10.1117/12.347546

KEYWORDS: Optical lithography, Statistical analysis, Waveguides, Sensors, Luminescence, Molecules, Biosensors, Semiconductor lasers, CCD cameras, Analytical research

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Proceedings Article | 26 March 1998 Paper

Array biosensor for multi-analyte sensing

Frances Ligler, David Conrad, Joel Golden, Mark Feldstein, Brian MacCraith, Stephanie Balderson, Joseph Czarnaski, Chris Rowe-Taitt

Proceedings Volume 3258, (1998) https://doi.org/10.1117/12.304363

KEYWORDS: Microscopes, Statistical analysis, Waveguides, Sensors, Blood, Glasses, Luminescence, Biosensors, Charge-coupled devices, Signal detection

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Proceedings Article | 30 May 1997 Paper

Continuous flow fluorescence based immunosensor for the detection of explosives and environmental pollutants

Paul Charles, John Bart, Linda Judd, Paul Gauger, Frances Ligler, Anne Kusterbeck

Proceedings Volume 3105, (1997) https://doi.org/10.1117/12.276137

KEYWORDS: Explosives detection, Statistical analysis, Luminescence, Solids, Explosives, Analytical research, Analog electronics, Pollution detection, Environmental sensing, Soil contamination

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Proceedings Article | 7 May 1997 Paper

Enhanced biosensor performance using an avidin-biotin bridge for antibody immobilization

Upvan Narang, George Anderson, Keeley King, Heidi Liss, Frances Ligler

Proceedings Volume 2980, (1997) https://doi.org/10.1117/12.273534

KEYWORDS: Optical fibers, Fiber optics, Capillaries, Luminescence, Medical research, Biosensors, Photodiodes, Adsorption, Bridges, Analytical research

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SPIE Journal Paper | 1 April 1997

Portable multichannel fiber optic biosensor for field detection

Joel Golden, Elric Saaski, Lisa Shriver-Lake, George Anderson, Frances Ligler

OE, Vol. 36, Issue 04, (April 1997) https://doi.org/10.1117/12.10.1117/1.601146

KEYWORDS: Biosensors, Calibration, Fiber optics, Luminescence, Sensors, Analytical research, Receivers, Fiber optics sensors, Photodiodes, Fiber lasers

Proceedings Article | 31 March 1997 Paper

Photoactivatable silanes for the site-specific immobilization of antibodies

David Conrad, Anna Davis, Sara Golightley, John Bart, Frances Ligler

Proceedings Volume 2978, (1997) https://doi.org/10.1117/12.269962

KEYWORDS: Proteins, Silica, Capillaries, Ultraviolet radiation, Luminescence, Silicon, Atomic force microscopy, Adsorption, Charge-coupled devices, Semiconducting wafers

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SPIE Journal Paper | 2 January 1997 Open Access

Patterned planar array immunosensor for multianalyte detection

Randy Wadkins, Joel Golden, Frances Ligler

JBO, Vol. 2, Issue 01, (January 1997) https://doi.org/10.1117/12.10.1117/12.259620

KEYWORDS: Charge-coupled devices, Glasses, Biosensors, Luminescence, CCD image sensors, Biological research, Polymers, GRIN lenses, Signal detection, Sensors

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Proceedings Article | 24 April 1996 Paper

Simultaneous measurement of Cy5.5-labeled capture antibodies and Cy5-labeled antigens in a fiber optic biosensor: photobleaching and resonance energy transfer effects during fiber regeneration

Randy Wadkins, Joel Golden, Frances Ligler

Proceedings Volume 2676, (1996) https://doi.org/10.1117/12.238793

KEYWORDS: Fiber optics, Calibration, Spectroscopy, Luminescence, Biosensors, Fiber lasers, Resonance energy transfer, Fluorescence resonance energy transfer, Analog electronics, Fiber optics tests

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Proceedings Article | 8 May 1995 Paper

Antibody-based fluorometric assay for detection of the explosives TNT and PETN

Linda Judd, Anne Kusterbeck, David Conrad, Hao Yu, Herbert Myles, Frances Ligler

Proceedings Volume 2388, (1995) https://doi.org/10.1117/12.208478

KEYWORDS: Explosives detection, Statistical analysis, Luminescence, Molecules, Solids, Explosives, Analytical research, Signal generators, Signal detection, Environmental sensing

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Proceedings Article | 8 May 1995 Paper

Effect of wavelength and dye selection on biosensor response

Frances Ligler, Kristen Breslin, Lynn Cao, George Anderson

Proceedings Volume 2388, (1995) https://doi.org/10.1117/12.208480

KEYWORDS: Fiber optics, Blood, Luminescence, Molecules, Biosensors, Semiconductor lasers, Analytical research, Signal generators, Plasma, Rhodamine

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Proceedings Article | 19 January 1995 Paper

Fiber optic biosensor for the detection of TNT

Lisa Shriver-Lake, Kristen Breslin, Joel Golden, Linda Judd, John Choi, Frances Ligler

Proceedings Volume 2367, (1995) https://doi.org/10.1117/12.199680

KEYWORDS: Defense and security, Fiber optics, Water, Molecules, Bioalcohols, Biosensors, Fiber optics sensors, Chemical analysis, Explosives, Analog electronics

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Proceedings Article | 21 October 1994 Paper

Use of cyanine dyes with evanescent wave fiber optic biosensors

Linda Tempelman, Joel Golden, George Anderson, Frances Ligler

Proceedings Volume 2293, (1994) https://doi.org/10.1117/12.190964

KEYWORDS: Optical filters, Proteins, Fiber optics, Luminescence, Biosensors, Semiconductor lasers, Biological research, Mass attenuation coefficient, Signal detection, Bandpass filters

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Proceedings Article | 27 July 1994 Paper

Near-IR biosensor for evanescent wave immunoassays

Joel Golden, Lisa Shriver-Lake, Narasimhachari Narayanan, Gabor Patonay, Frances Ligler

Proceedings Volume 2138, (1994) https://doi.org/10.1117/12.181363

KEYWORDS: Near infrared, Mirrors, Proteins, Fiber optics, Sensors, Luminescence, Laser development, Biosensors, Semiconductor lasers, Camera shutters

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Proceedings Article | 28 March 1994 Paper

Flow immunosensor detection of explosives and drugs of abuse

Anne Kusterbeck, Linda Judd, Hao Yu, June Myles, Frances Ligler

Proceedings Volume 2092, (1994) https://doi.org/10.1117/12.171242

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Proceedings Article | 10 March 1994 Paper

Comparative analysis of toxin detection in biological and enviromental samples

Robert Ogert, James Burans, Tom O'Brien, Frances Ligler

Proceedings Volume 2068, (1994) https://doi.org/10.1117/12.170677

KEYWORDS: Proteins, Statistical analysis, Silica, Fiber optics, Luminescence, Medical research, Biosensors, Fiber optics sensors, Absorbance, Biological research

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Proceedings Article | 18 May 1993 Paper

Toxin detection using a fiber-optic-based biosensor

Robert Ogert, Lisa Shriver-Lake, Frances Ligler

Proceedings Volume 1885, (1993) https://doi.org/10.1117/12.144706

KEYWORDS: Optical filters, Proteins, Waveguides, Fiber optics, Luminescence, Biosensors, Detector development, Connectors, Analytical research, Signal detection

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Proceedings Article | 30 April 1993 Paper

Evanescent-wave fiber optic biosensor: challenges for real-world sensing

Joel Golden, George Anderson, Robert Ogert, Kristen Breslin, Frances Ligler

Proceedings Volume 1796, (1993) https://doi.org/10.1117/12.143494

KEYWORDS: Statistical analysis, Fiber optics, Sensors, Luminescence, Biosensors, Wave sensors, Biological research, Analytical research, Signal generators, Environmental sensing

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