Dr. Franz Pfeiffer Profile

Dr. Franz Pfeiffer

Professor, Laser Medicine at Technische Univ München

SPIE Involvement:

Author

Publications (56)

SPIE Journal Paper | 22 April 2020

Dose and spatial resolution analysis of grating-based phase-contrast mammography using an inverse Compton x-ray source

Lisa Heck, Elena Eggl, Susanne Grandl, Martin Dierolf, Christoph Jud, Benedikt Günther, Klaus Achterhold, Doris Mayr, Bernhard Gleich, Karin Hellerhoff, Franz Pfeiffer, Julia Herzen

JMI Vol. 7 Issue 02

KEYWORDS: Spatial resolution, Mammography, X-rays, Breast, Tumors, Sensors, Tissues, X-ray sources, Absorption, Diagnostics

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SPIE Journal Paper | 21 April 2020

K-edge subtraction imaging for iodine and calcium separation at a compact synchrotron x-ray source

Stephanie Kulpe, Martin Dierolf, Eva-Maria Braig, Benedikt Günther, Klaus Achterhold, Bernhard Gleich, Julia Herzen, Ernst Rummeny, Franz Pfeiffer, Daniela Pfeiffer

JMI Vol. 7 Issue 02

KEYWORDS: Iodine, X-rays, Synchrotrons, Calcium, Image filtering, X-ray imaging, Signal attenuation, X-ray sources, Absorption, Tissues

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Proceedings Article | 1 October 2019 Paper

New staining tools and developments for 3D soft tissue CT imaging

Madleen Busse, Simone Ferstl, Mark Müller, Melanie Kimm, Enken Drecoll, Toni Bürkner, Sebastian Allner, Lorenz Hehn, Martin Dierolf, Klaus Achterhold, Julia Herzen, Daniela Pfeiffer, Ernst Rummeny, Wilko Weichert, Franz Pfeiffer

Proc. SPIE. 11113, Developments in X-Ray Tomography XII

KEYWORDS: X-ray computed tomography, Visualization, Tissues, Signal attenuation, Microscopy, X-rays, Bioalcohols, Kidney, X-ray imaging, 3D image processing

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Proceedings Article | 19 September 2019 Presentation + Paper

In vivo x-ray imaging of the respiratory system using synchrotron sources and a compact light source

Kaye Susannah Morgan, Regine Gradl, Martin Dierolf, Christoph Jud, Benedikt Günther, Freda Werdiger, Mark Gardner, Patricia Cmielewski, Alexandra McCarron, Nigel Farrow, Helena Haas, Melanie Kimm, Lin Yang, David Kutschke, Tobias Stoeger, Otmar Schmid, Klaus Achterhold, Franz Pfeiffer, David Parsons, Martin Donnelley

Proc. SPIE. 11113, Developments in X-Ray Tomography XII

KEYWORDS: Light sources, X-rays, X-ray sources, Lung, Medical imaging, Spatial coherence, Synchrotrons, In vivo imaging, X-ray imaging, Synchrotron x-ray imaging

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Bright synchrotron x-ray sources enable imaging with short exposure times, and hence in a high-speed image sequence. These x-ray movies can capture not only sample structure, but also how the sample changes with time, how it functions. The use of a synchrotron x-ray source also provides high spatial coherence, which facilitates the capture of not only a conventional attenuation-based x-ray image, but also phase-contrast and dark-field signals. These signals are strongest from air/tissue interfaces, which means that they are particularly useful for examining the respiratory system. We have performed a range of x-ray imaging studies that look at lung function, airway surface function, inhaled and instilled treatment delivery, and treatment effect in live small animal models [Morgan, 2019]. These have utilized a range of optical set-ups and phase-contrast imaging methods in order to be sensitive to the relevant sample features, and be compatible with high-speed imaging. For example, we have used a grating interferometer to measure how the airsacs in the lung inflate during inhalation, via changes in the dark-field signal [Gradl, 2018], a single-exposure, single-grid set-up to capture changes in the liquid lining of the airways [Morgan, 2015] and propagation-based phase contrast to image clearance of inhaled debris [Donnelley, 2019]. Studies have also utilized a range of analysis methods to extract how the sample features change within a time-sequence of two-dimensional projections or three-dimensional volumes. While these imaging studies began in large-scale synchrotron facilities, we have recently performed these kinds of studies at an inverse-Compton-based compact synchrotron, the Munich Compact Light Source (MuCLS) [Gradl, 2018b]. 1. Morgan, Kaye, et al., “Methods for dynamic synchrotron X-ray imaging of live animals.”, under review 01/2019. 2. Gradl, R., et al. "Dynamic in vivo chest x-ray dark-field imaging in mice." IEEE Transactions on Medical Imaging (2018). 3. Morgan, Kaye S., et al. "In vivo X-ray imaging reveals improved airway surface hydration after a therapy designed for cystic fibrosis." American Journal of Respiratory and Critical Care Medicine 190.4 (2014): 469-472. 4. Donnelley, Martin, et al. "Live-pig-airway surface imaging and whole-pig CT at the Australian Synchrotron Imaging and Medical Beamline." Journal of Synchrotron Radiation 26.1 (2019). 5. Gradl, Regine, et al. "In vivo Dynamic Phase-Contrast X-ray Imaging using a Compact Light Source." Scientific Reports 8.1 (2018b): 6788.

Proceedings Article | 10 September 2019 Paper

Single-energy material decomposition with grating-based x-ray phase-contrast CT

Eva-Maria Braig, Martin Dierolf, Benedikt Guenther, Korbinian Mechlem, Sebastian Allner, Thorsten Sellerer, Klaus Achterhold, Bernhard Gleich, Ernst Rummeny, Daniela Pfeiffer, Franz Pfeiffer, Julia Herzen

Proc. SPIE. 11113, Developments in X-Ray Tomography XII

KEYWORDS: Tunable lasers, X-ray computed tomography, Visualization, Signal attenuation, Pathology, X-rays, Diagnostics, Phase measurement, X-ray imaging, Dual energy imaging

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Proceedings Article | 10 September 2019 Paper

Dose and spatial resolution analysis of grating-based phase-contrast mammography using an inverse Compton x-ray source

L. Heck, E. Eggl, S. Grandl, M. Dierolf, C. Jud, B. Günther, K. Achterhold, D. Mayr, B. Gleich, K. Hellerhoff, F. Pfeiffer, J. Herzen

Proc. SPIE. 11113, Developments in X-Ray Tomography XII

KEYWORDS: Breast, Breast cancer, Tissues, X-rays, X-ray sources, Diagnostics, Quantitative analysis, Mammography, Synchrotrons, Absorption

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Proceedings Article | 9 September 2019 Paper

K-edge subtraction imaging for angiography at a compact synchrotron source

Stephanie Kulpe, Martin Dierolf, Eva-Maria Braig, Benedikt Günther, Klaus Achterhold, Bernhard Gleich, Julia Herzen, Ernst Rummeny, Franz Pfeiffer, Daniela Pfeiffer

Proc. SPIE. 11110, Advances in Laboratory-based X-Ray Sources, Optics, and Applications VII

KEYWORDS: X-rays, Calcium, Iodine, Angiography, Synchrotrons, X-ray imaging, Absorption

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Proceedings Article | 9 September 2019 Presentation + Paper

Evaluation and optimization of multimodal x-ray imaging techniques for inverse Compton x-ray sources

Benedikt Günther, Regine Gradl, Christoph Jud, Elena Eggl, Stephanie Kulpe, Eva-Maria Braig, Lisa Heck, Johannes Brantl, Klaus Achterhold, Bernhard Gleich, Martin Dierolf, Franz Pfeiffer

Proc. SPIE. 11110, Advances in Laboratory-based X-Ray Sources, Optics, and Applications VII

KEYWORDS: Phase contrast, X-rays, X-ray sources, X-ray microscopy, Lung, In vivo imaging, Synchrotron radiation, X-ray imaging, X-ray medical imaging, Absorption

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Proceedings Article | 28 May 2019 Paper

Task-driven acquisition in anisotropic x-ray dark-field tomography

Theodor Cheslerean Boghiu, Franz Pfeiffer, Tobias Lasser

Proc. SPIE. 11072, 15th International Meeting on Fully Three-Dimensional Image Reconstruction in Radiology and Nuclear Medicine

KEYWORDS: Scattering, Interferometers, X-rays, Tomography, Reconstruction algorithms, Modulation transfer functions, X-ray imaging, Optimization (mathematics)

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Proceedings Article | 28 May 2019 Paper

Statistical iterative reconstruction for spectral phase contrast CT

Korbinian Mechlem, Thorsten Sellerer, Julia Herzen, Franz Pfeiffer

Proc. SPIE. 11072, 15th International Meeting on Fully Three-Dimensional Image Reconstruction in Radiology and Nuclear Medicine

KEYWORDS: Photon counting, Phase contrast, X-ray computed tomography, Numerical simulations, Reconstruction algorithms, X-ray imaging

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Proceedings Article | 9 March 2018 Paper

Calcium decomposition and phantomless bone mineral density measurements using dual-layer-based spectral computed tomography

Kai Mei, Benedikt Schwaiger, Felix Kopp, Sebastian Ehn, Alexandra Gersing, Jan Kirschke, Daniela Munzel, Alexander Fingerle, Ernst Rummeny, Franz Pfeiffer, Thomas Baum, Peter Noël

Proc. SPIE. 10573, Medical Imaging 2018: Physics of Medical Imaging

KEYWORDS: Calibration, Bone, Computed tomography, Algorithm development, Spectral computed tomography

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Proceedings Article | 2 May 2017 Presentation