Dr. Hamid Farrokhi Profile

Dr. Hamid Farrokhi

Research and Design Engineer at Wellman Ctr for Photomedicine

Area of Expertise:

laser-matter interaction , quantitative phase imaging , in vivo biomedical microscopy , laser additive manufacturing

Dr. Hamid Farrokhi is working as Research and Design engineer in the Wellman Center for Photomedicine and as Research Associate in Harvard Medical School. His position involves the engineering of novel medical in vivo microscopy devices, including the design, fabrication, validation and manufacturing of optics, electronics, mechanics and system integration to create completed medical device prototypes.

Research Interests
1. Laser-matter (tissue) interaction.
2. Laser micromachining and nanofabrication.
3. Quantitative phase imaging
4. in vivo biomedical microscopy

SPIE Journal Paper | 12 November 2021 Open Access

Label-free quantitative measurement of cardiovascular dynamics in a zebrafish embryo using frequency-comb-referenced-quantitative phase imaging

Jeeranan Boonruangkan, Hamid Farrokhi, Rohith Madam, Samuel Kwok, Tom Carney, Pei-Chen Su, Young-Jin Kim

JBO, Vol. 26, Issue 11, 116004, (November 2021) https://doi.org/10.1117/12.10.1117/1.JBO.26.11.116004

KEYWORDS: Heart, Blood, Blood circulation, Blood vessels, Signal to noise ratio, Photodetectors, Phase imaging, Speckle, Beam propagation method, CCD cameras

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SPIE Journal Paper | 10 February 2021 Open Access

Improved sensitivity roll-off in dual reference, buffered spectral-domain optical coherence tomography

David Otuya, Yogesh Verma, Romain Luu, Hamid Farrokhi, Guillermo Tearney

JBO, Vol. 26, Issue 02, 025001, (February 2021) https://doi.org/10.1117/12.10.1117/1.JBO.26.2.025001

KEYWORDS: Interferometers, Optical coherence tomography, Imaging systems, In vivo imaging, Colon, Spectroscopy, Tissues, Ranging, Range imaging, Tissue optics

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Proceedings Article | 4 March 2019 Presentation

Minimally invasive trans-nasal biopsy of the small intestine (Conference Presentation)

David Otuya, Hamid Farrokhi, Jing Dong, Rachel Shore, Mason Schellenberg, Sarah Giddings, Nitasha Mudalaje, Catriona Grant, Aaron Baillargeon, Joseph Gardecki, Norman Nishioka, Christopher Damman, Guillermo Tearney

Proceedings Volume 10854, 108540M (2019) https://doi.org/10.1117/12.2510447

KEYWORDS: Biopsy, Intestine, Endoscopy, Optical coherence tomography, Metals, Absorption, Diagnostics, Gold, In vivo imaging, Tissues

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Proceedings Article | 4 March 2019 Presentation

Transnasal introduction catheter, a new platform for imaging and biopsying the gastrointestinal (GI) tract (Conference Presentation)

Hamid Farrokhi, Jing Dong, David Otuya, Yogesh Verma, Sarah Zemlok, Aditya Kumar, Rachel Shore, Sarah L. Giddings, Nitasha G. Bhat, Omair Shakil, Catriona Grant, Norman Nishioka, Mireille Rosenberg, Christopher Damman, Guillermo Tearney

Proceedings Volume 10854, 108540L (2019) https://doi.org/10.1117/12.2510381

KEYWORDS: Endoscopy, Biopsy, Optical coherence tomography, Stomach, Endomicroscopy, Tissues, Visualization, Francium, Real time imaging, Liquids

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Proceedings Article | 4 March 2019 Presentation

Duodenal imaging by tethered capsule OCT endomicroscopy in adolescents with environmental enteric dysfunction (Conference Presentation)

Jing Dong, Kamran Sadiq, Catriona Grant, Omair Shakil, David Otuya, Hamid Farrokhi, Anna Gao, Nitasha Bhat, Sarah Giddings, Kumail Ahmed, Seema Rani, Mireille Rosenberg, Alessio Fasano, Christopher Damman, Asad Ali, Guillermo Tearney

Proceedings Volume 10854, 1085408 (2019) https://doi.org/10.1117/12.2513965

KEYWORDS: Optical coherence tomography, Endomicroscopy, Intestine, Endoscopy, Inflammation, Biopsy, 3D image processing, Visualization, Control systems

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Environmental Enteric Dysfunction (EED) is a poorly understood condition of the small intestine that is prevalent in regions of the world with inadequate sanitation and hygiene. EED affects 25% of all children globally and causes over a million deaths each year. The condition is associated with increased intestinal permeability, bacterial translocation, inflammation and villous blunting. The loss of absorptive area and intestinal function leads to nutrient malabsorption, with long term outcomes characterized by stunted growth and neurocognitive development. Currently, the only way to directly evaluate the morphology of the intestine is endoscopy with mucosal biopsy. Yet because EED is endemic in low and middle-income countries, endoscopy is untenable for studying EED. As a result, the diagnosis of EED and the assessment of the efficacy of EED interventions is hampered by an inability to evaluate the intestinal mucosa. Our lab has previously developed a technology termed tethered capsule OCT endomicroscopy (TCE). The method involves swallowing an optomechanically-engineered pill that generates 3D images of the GI tract as it traverses the lumen of the organ via peristalsis, assisted by gravity. In order to study the potential of using TCE to investigate EED, we initiated and conducted a TCE study in adolescents at Aga Khan Medical Center in Pakistan. To make swallowing easier, the tethered capsule’s size was reduced from 11x25 mm to 8x22 mm. Villous morphologic visualization was enhanced by building a notch (x mm deep, y mm wide) in the capsule’s imaging window. To date, 26 Pakistani subjects with ages ranging from 14 to 18 y/o (16.4 +/- 1.0) have been enrolled and imaged. A total of 19 subjects were able to swallow the capsule. Of those, 9 successfully passed through the pylorus, allowing successful microscopic imaging of the entire duodenum. There were no adverse events in any of the cases. Maximum villous height and width were measured from 3 randomly chosen, representative frames from each Pakistan subject as well as a matching number from US controls. Preliminary results, comparing Pakistani vs US villous morphology, indicated that subjects from Pakistan have shorter (628.6 +/- 22.0 um and 492.3 +/- 13.2 um, respectively, p< 0.0001) and wider duodenal villi (244.9 +/- 8.8 um and 293.4 +/- 13.2 um, respectively, p< 0.0001). These findings suggest that OCT TCE of the duodenum may be a useful tool for evaluating villous morphology in EED.

Proceedings Article | 14 March 2018 Presentation

Trans-nasal OCT imaging of the small intestine (Conference Presentation)

David Otuya, Yogesh Verma, Jing Dong, Hamid Farrokhi, Sarah Giddings, Nitasha G. Bhat, Omair Shakil, Catriona Grant, Guillermo Tearney

Proceedings Volume 10470, 104700Z (2018) https://doi.org/10.1117/12.2290732

KEYWORDS: Optical coherence tomography, Intestine, Coherence imaging, Francium, Imaging devices

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Proceedings Article | 14 March 2018 Presentation

Optical coherence tomography-guided laser marking with tethered capsule endomicroscopy (Conference Presentation)

Chia-Pin Liang, Jing Dong, Timothy Ford, Rohith Reddy, Seyed Hamid Hosseiny Darbrazi, Hamid Farrokhi, Matthew Beatty, Kanwarpal Singh, Barry Vuong, Emilie Beaulieu-Ouellet, Catriona Grant, Sarah Giddings, Mireille Rosenberg, Norman Nishioka, Guillermo Tearney

Proceedings Volume 10470, 104700X (2018) https://doi.org/10.1117/12.2287843

KEYWORDS: Laser marking, Optical coherence tomography, Endomicroscopy, Endoscopy, Laser optics, Coherence (optics), Esophagus, Cancer, Surveillance, Diagnostics

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Proceedings Article | 11 February 2011 Paper

Sub-micron texturing of silicon wafer with fiber laser

Hamid Farrokhi, Wei Zhou, Hong Yu Zheng, Zhongli Li

Proceedings Volume 7926, 792607 (2011) https://doi.org/10.1117/12.874919

KEYWORDS: Silicon, Oxygen, Raman spectroscopy, Semiconductor lasers, Scanning electron microscopy, Fiber lasers, X-rays, Spectroscopy, Reflection, Semiconducting wafers

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