Dr. Huihui Lu Profile

Dr. Huihui Lu

Researcher at Tyndall National Institute

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Publications (15)

Proceedings Article | 28 February 2024 Paper

Spectral feature exploration for lactate sensing using long wavelength near infrared spectroscopy lactate sensing for non-invasive continuous hypoxia assessment in intra-partum fetus

Shree Krishnamoorthy, Huihui Lu, Walter Messina, Fergus McCarthy, Stefan Andersson-Engels, Ray Burke

Proceedings Volume 12628, 126280C (2024) https://doi.org/10.1117/12.2669908

KEYWORDS: Hypoxia, Fetus, Near infrared spectroscopy, Urea, Traumatic brain injury, Spectroscopy, Reflectivity, Oxygen, Liquids, Gold

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SPIE Journal Paper | 5 September 2023 Open Access

Frameworks of wavelength selection in diffuse reflectance spectroscopy for tissue differentiation in orthopedic surgery

Celina Li, Carl Fisher, Katarzyna Komolibus, Konstantin Grygoryev, Huihui Lu, Ray Burke, Andrea Visentin, Stefan Andersson-Engels

JBO, Vol. 28, Issue 12, 121207, (September 2023) https://doi.org/10.1117/12.10.1117/1.JBO.28.12.121207

KEYWORDS: Bone, Tissues, Principal component analysis, Cements, Diffuse reflectance spectroscopy, Surgery, Data modeling, Education and training, Feature selection, Absorption

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Proceedings Article | 11 August 2023 Paper

Biophotonics diagnostics of oral cancer using Raman spectroscopy

Siddra Maryam, M. Daniyal Ghauri, Edward Fahy, Sanathana Konugolu Venkata Sekar, Marcelo Saito Nogueira, Huihui Lu, Alida Russo, Ray Burke, Linda Feelay, Patrick Sheahan, Richeal Ni Riordain, Stefan Andersson-Engels, Kiang Wei Kho, Rekha Gautam

Proceedings Volume 12627, 126270B (2023) https://doi.org/10.1117/12.2670600

KEYWORDS: Raman spectroscopy, Cancer, Tissues, Diagnostics, Biopsy, Surface enhanced Raman spectroscopy, In vivo imaging, Statistical analysis, Spectroscopy, Proteins

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Proceedings Article | 9 August 2023 Paper

Use of derivative diffuse reflectance spectroscopy in CAM assay combined with multivariate analysis as an approach to detect features of vulnerable plaques

Huihui Lu, Claire O’Dowling, Noel Caplice, Ray Burke, Stefan Andersson-Engels

Proceedings Volume 12628, 126281L (2023) https://doi.org/10.1117/12.2670678

KEYWORDS: Reflectivity, Veins, Arteries, Diffuse reflectance spectroscopy, Content addressable memory, Tissues, Oxygenation, Data modeling, Spectroscopy, Atherosclerosis

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Proceedings Article | 6 March 2023 Poster + Paper

Multimodal optical spectroscopic approach to design a complete protocol for early diagnosis of oral cancer

Siddra Maryam, M. Daniyal Ghauri, Edward Fahy, Sanathana Konugolu Venkata Sekar, Huihui Lu, Alida Russo, Marcelo Saito Nogueira, Ray Burke, Linda Feeley, Patrick Sheahen, Richeal Ni Riordain, Stefan Andersson-Engels, Kiang Wei Kho, Rekha Gautam

Proceedings Volume 12368, 123680O (2023) https://doi.org/10.1117/12.2650536

KEYWORDS: Cancer, Surface enhanced Raman spectroscopy, Raman spectroscopy, Tissues, Spectroscopy, Cancer detection, Optical spectroscopy, Diffuse reflectance spectroscopy

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Proceedings Article | 4 March 2022 Presentation + Paper

Accurate colorectal cancer detection and delineation by probing superficial and deeper tissue biochemistry and microstructure using diffuse reflectance spectroscopy

Marcelo Saito Nogueira, Michael Raju, Jacqueline Gunther, Siddra Maryam, Michael Amissah, Shane Killeen, Huihui Lu, Micheal O’Riordain, Stefan Andersson-Engels

Proceedings Volume 11943, 1194302 (2022) https://doi.org/10.1117/12.2609547

KEYWORDS: Tissues, Cancer, Colorectal cancer, Error control coding, Blood, Scattering, Tumors, Diffuse reflectance spectroscopy, Chromophores, Mie scattering, Spectral data processing, Near infrared spectroscopy, Hyperspectral imaging, Optical properties, Monte Carlo methods

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Colorectal cancer (CRC) is the third most common and the second most deadly type of cancer worldwide. Developing new technologies for accurate CRC detection/delineation for resection during microsurgery requires unveiling tissue biochemical and microstructural changes associated with carcinogenesis. These changes can be probed by diffuse reflectance spectroscopy (DRS), which is capable of extracting tissue chromophore concentrations and scattering parameters. Previous CRC studies have been mostly restricted to chromophores in the visible region and analytical light diffusion models. In this study, we extended this wavelength range to 350–1919 nm and used the range between 450–1590 nm to extract tissue biochemical and microstructural parameters. This extraction was performed by using DRS spectral fitting based on a reflectance look-up table built using Monte Carlo simulations of light propagation in tissues. Tissue parameters were used as an input to classification and regression tree algorithm to estimate parameter thresholds leading to best tissue differentiation for CRC detection/delineation. Differentiation between mucosa and tumor tissues was based on 2889 diffuse reflectance spectra from fresh ex vivo tissue samples from 47 subjects. All analyses were performed to investigate data of superficial tissue up to 1.1 mm and deeper tissue layers up to 1.8 mm. The most important parameters for CRC detection were total lipid content, water content, reduced scattering amplitude, Mie scattering power, and microvascular parameters. We not only confirmed the importance of these parameters with metrics in addition to statistical tests and classification models of our previous studies, but also extended the motivation of achieving successful tissue classification with an area under the receiver operating characteristic curve (AUC) higher than 90% with interpretable DRS spectral fitting parameters. Our analysis may have important clinical applications for the rapid diagnosis of colorectal neoplasia.

Proceedings Article | 2 March 2022 Presentation + Paper

Multi-configuration Raman spectrometer for early stage diagnosis of oral cancer

Siddra Maryam, Marcelo Saito Nogueira, Shree Krishna Moorthy, Sanathana Sekar, Huihui Lu, Rekha Gautam, Ray Burke, Stefan Andersson-Engels, Richeal Ni Riordain, Patrick Sheahan

Proceedings Volume 11957, 1195706 (2022) https://doi.org/10.1117/12.2610704

KEYWORDS: Raman spectroscopy, Cancer, Nanoparticles, In vivo imaging, Tumors, Molecules, Tissues, Surface enhanced Raman spectroscopy, Diagnostics, Reflection

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Proceedings Article | 2 March 2022 Presentation + Paper

Improving colorectal cancer detection by extending the near-infrared wavelength range and tissue probed depth of diffuse reflectance spectroscopy: a support vector machine approach

Marcelo Saito Nogueira, Siddra Maryam, Michael Amissah, Huihui Lu, Noel Lynch, Shane Killeen, Micheal O'Riordain, Stefan Andersson-Engels

Proceedings Volume 11954, 1195404 (2022) https://doi.org/10.1117/12.2610497

KEYWORDS: Tissues, Tissue optics, Colorectal cancer, Error control coding, Diffuse reflectance spectroscopy, Biomedical optics, Cancer, Luminescence, Spectroscopy, Fluorescence spectroscopy, Machine learning, Spectral data processing, Near infrared spectroscopy, Hyperspectral imaging, Artificial intelligence

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SPIE Journal Paper | 5 January 2022 Open Access

Perspective on the integration of optical sensing into orthopedic surgical devices

Carl Fisher, James Harty, Albert J. Yee, Celina Li, Katarzyna Komolibus, Konstantin Grygoryev, Huihui Lu, Ray Burke, Brian Wilson, Stefan Andersson-Engels

JBO, Vol. 27, Issue 01, 010601, (January 2022) https://doi.org/10.1117/12.10.1117/1.JBO.27.1.010601

KEYWORDS: Surgery, Bone, Optical sensing, Tissue optics, Integrated optics, Tissues, Optical properties, Robotics, Soft tissue optics, Scattering

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Proceedings Article | 9 March 2020 Presentation

Broadband diffuse reflectance spectroscopy for colorectal surgical guidance (Conference Presentation)

Marcelo Saito Nogueira, Siddra Maryam, Michael Amissah, Huihui Lu, Edmund Manning, Shane Killeen, Micheal O'Riordain, Stefan Andersson-Engels

Proceedings Volume 11238, 1123802 (2020) https://doi.org/10.1117/12.2546803

KEYWORDS: Diffuse reflectance spectroscopy

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SPIE Journal Paper | 22 February 2020 Open Access

Combination of diffuse reflectance and transmittance spectroscopy to obtain optical properties of liquid phantoms

Jacqueline Gunther, Huihui Lu, Stefan Andersson-Engels

OE, Vol. 59, Issue 02, 024109, (February 2020) https://doi.org/10.1117/12.10.1117/1.OE.59.2.024109

KEYWORDS: Optical properties, Transmittance, Absorption, Diffuse reflectance spectroscopy, Reflectance spectroscopy, Reflectivity, Scattering, Liquids, Calibration, Monte Carlo methods

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Proceedings Article | 20 November 2019 Paper

Fluorescence spectroscopy study of protoporphyrin IX in tissue-like phantoms

Huihui Lu, Francesco Floris, Marc Rensing, Stefan Andersson-Engels

Proceedings Volume 11190, 111901S (2019) https://doi.org/10.1117/12.2537000

KEYWORDS: Tissue optics, Fluorescence spectroscopy, Tissues, Biomedical optics, Liquids, Luminescence, Cancer, Oncology

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Proceedings Article | 23 October 2018 Paper

Determination optical properties of tissue-like phantoms using diffuse reflectance and transmittance spectroscopy

Huihui Lu, Jacqueline Gunther, Stefan Andersson-Engels

Proceedings Volume 10820, 108202X (2018) https://doi.org/10.1117/12.2501183

KEYWORDS: Transmittance, Reflectivity, Diffuse reflectance spectroscopy, Optical properties, Scattering, Absorption, Tissue optics, Monte Carlo methods, Spectroscopy, Reflectance spectroscopy

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Proceedings Article | 17 May 2018 Paper

Diffuse reflectance spectroscopy for determination of optical properties and chromophore concentrations of mice internal organs in the range of 350 nm to 1860 nm

Marcelo Saito Nogueira, Michael Raju, Jacqueline Gunther, Konstantin Grygoryev, Katarzyna Komolibus, Huihui Lu, Stefan Andersson-Engels

Proceedings Volume 10685, 106853G (2018) https://doi.org/10.1117/12.2306636

KEYWORDS: Tissues, Scattering, Reflectivity, Heart, Liver, Mie scattering, Kidney, Chromophores, Optical properties, Rayleigh scattering, Diffuse reflectance spectroscopy, Optical diagnostics, Biomedical optics, Biophotonic applications, Monte Carlo methods

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Proceedings Article | 17 February 2017 Presentation + Paper

Hybrid integration of VCSELs onto a silicon photonic platform for biosensing application

Huihui Lu, Jun Su Lee, Yan Zhao, Paolo Cardile, Aidan Daly, Lee Carroll, Peter O'Brien

Proceedings Volume 10072, 100720K (2017) https://doi.org/10.1117/12.2250859

KEYWORDS: Silicon photonics, Vertical cavity surface emitting lasers, Biosensing, Photonic integrated circuits, Diagnostics, Life sciences, New and emerging technologies, Waveguides, Tolerancing, Connectors, Optical design, Packaging, Optical alignment

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Showing 5 of 15 publications

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