Dr. Igor V. Malov Profile

Dr. Igor V. Malov

at Samara State Medical Univ

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Publications (2)

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Proceedings Article | 19 December 2022 Presentation + Paper

Investigating the sclera fluorescence in order to obtain AGE related diagnostic information

Dmitriy Kornilin, Vladimir Grishanov, Igor Malov

Proceedings Volume 12320, 123201A (2022) https://doi.org/10.1117/12.2644137

KEYWORDS: Skin, Sclera, Fluorescence, Diagnostics, Autofluorescence, Scattering, Tissues, Semiconductor lasers, Fluorescence intensity

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It is known the disadvantages of assessing the content of advanced glycation end products (AGE) in the human body using autofluorescence of the skin. There are dependence on the skin phototypes, influence of hair, surface macrostructure and compression of biological tissues during investigation on AGE readers. On the other hand, the sclera of the eye is also composed of glycated collagen fibers and is available for in vivo fluorescence level estimation. This approach removes restrictions on the skin phototype and reduces the influence of other drawbacks. This study experimentally approves the opportunity of measuring the fluorescence of the human eye sclera in vivo for assessing the content of AGE in biological tissues. A correlation between the fluorescence of the skin of the hand and the sclera was established. The investigation of autofluorescence of the sclera and skin of the inner side of the forearm were carried out using a slit lamp. This lamp was equipped by authors with a semiconductor violet laser with a peak wavelength of 405 nm. This violet laser excites AGE fluorescence. A color camera was utilized as a photodetector. It was covered by a cutting violet light filter made of polyimide film 40 micrometer thick. The diagnostic parameter ("Sclera" or "SL skin") was the ratio of the arithmetic mean of two green pixels, one of which was exposed by violet laser, whereas another one was exposed by white light. The experiments involved 40 practically healthy subjects with ages from 18 till 70. The experimental results demonstrated an expected increase of diagnostic parameters within the age. The calculated values of the Pearson correlation coefficient between the diagnostic parameters "Sclera" / "Skin SL", "Sclera" / "Skin FL", "Skin SL" / "Skin FL" were 0.96; 0.95 and 0.99, respectively, indicating their significant statistical relationship.

Proceedings Article | 10 October 2020 Poster + Paper

Estimation of the advanced glycation end products accumulated by sclera using autofluorescence

Vladimir Grishanov, Dmitriy Kornilin, Igor Malov, Georgiy Pleshakov

Proceedings Volume 11553, 115532Z (2020) https://doi.org/10.1117/12.2581897

KEYWORDS: Sclera, Skin, Ultraviolet radiation, Luminescence, Lamps, Cameras, Semiconductor lasers, Photodetectors, Light emitting diodes, Light

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Evaluation of the concentration of glycation end products (AGE) in the human body utilizing autofluorescence is widely used in medical practice. The autofluorescence level is usually measured from the skin of the hand. However, this measurement can hardly be used for some of the human skin phototypes. On the other hand, the sclera of the eye also consists of collagen fibers that can be affected by glycation. Sclera autofluorescence can also be investigated in vivo by "hand-held" fluorescence meter. In this case, there are no effects of the skin phototype and no effect of pressure made by the hand on the fluorescence meter. Therefore, the study of correlation between the fluorescence of the skin of the hand and the sclera fluorescence is in the area of practical interest. In this research the results of the simultaneous measurements of skin and sclera autofluorescence made on 34 humans are presented. The "hand-held" fluorescence meter and an upgraded slit lamp were used as instruments. The value of the Pearson correlation coefficient was 0.89, which can be considered as successful validation of using fluorescence for assessment of the AGE content in the sclera.

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