Mr. Ivan Bozic Profile

Ivan Bozic

Doctoral Candidate

SPIE Involvement:

Author

Publications (9)

Proceedings Article | 17 March 2023 Presentation

Deep learning decomposition of overlapping channels in multicolor fluorescence virtual pathology

Ivan Bozic, Jonathon Brown

Proceedings Volume PC12363, PC123630B (2023) https://doi.org/10.1117/12.2649125

KEYWORDS: Luminescence, Pathology, Microscopy, Seaborgium, Gallium nitride, Nanoparticles, Multiplexing, Gold, Fluorescent markers, Detection and tracking algorithms

Read Abstract +

Proceedings Article | 2 March 2022 Paper

Structured illuminated microscopy virtual pathology for real-time large-specimen surgical pathology imaging using SYBR gold and eosin

Ivan Bozic, Madeline Behr, J. Quincy Brown

Proceedings Volume 11958, 119580B (2022) https://doi.org/10.1117/12.2607553

KEYWORDS: Pathology, Tissues, Microscopy, Signal to noise ratio, Prostate, Biopsy, Imaging systems, Bioalcohols, Spatial light modulators

Read Abstract +

Proceedings Article | 5 March 2021 Presentation

Quantitative assessment of fluorescence dyes and staining protocols for virtual hematoxylin and eosin (H&E) imaging using ex vivo microscopy

Ivan Bozic, Madeline Behr, Jonathon Brown

Proceedings Volume 11660, 1166007 (2021) https://doi.org/10.1117/12.2578455

KEYWORDS: Microscopy, Multiphoton microscopy, Luminescence, Multiphoton fluorescence microscopy, Image quality, Ultraviolet radiation, Tumors, Tissues, Signal to noise ratio, Prostate cancer

Read Abstract +

Proceedings Article | 5 March 2021 Presentation

Optical-sectioning super-resolution structured illumination microscopy for fast virtual pathology

Ivan Bozic, Jonathon Brown

Proceedings Volume 11622, 1162205 (2021) https://doi.org/10.1117/12.2578440

KEYWORDS: Super resolution, Pathology, Microscopy, Tissue optics, Tissues, Objectives, Natural surfaces, Image resolution, Tumors, Scattering

Read Abstract +

Proceedings Article | 19 February 2018 Presentation + Paper

Multimodality optical coherence tomography and fluorescence confocal scanning laser ophthalmoscopy in a zebrafish model of retinal vascular occlusion and remodeling

Xiaoyue Li, Kathleen Spitz, Ivan Bozic, Yuankai Tao

Proceedings Volume 10474, 1047402 (2018) https://doi.org/10.1117/12.2290930

KEYWORDS: Optical coherence tomography, Retina, Luminescence, Confocal microscopy, Scanning laser ophthalmoscopy, Biometrics, Plasma, Proteins, In vivo imaging, Pathology

Read Abstract +

Proceedings Article | 29 August 2017 Presentation + Paper

Multimodal ophthalmic imaging using spectrally encoded scanning laser ophthalmoscopy and optical coherence tomography

Mohamed El-Haddad, Joseph Malone, Jianwei Li, Ivan Bozic, Amber Arquitola, Karen Joos, Shriji Patel, Yuankai Tao

Proceedings Volume 10352, 1035209 (2017) https://doi.org/10.1117/12.2275552

KEYWORDS: Optical coherence tomography, Scanning laser ophthalmoscopy, Ophthalmic imaging, In vivo imaging, Signal detection, Multimodal imaging, Scanners, Imaging systems, Optical scanning systems, Optical tracking

Read Abstract +

Ophthalmic surgery involves manipulation of delicate, layered tissue structures on milli- to micrometer scales. Traditional surgical microscopes provide an inherently two-dimensional view of the surgical field with limited depth perception which precludes accurate depth-resolved visualization of these tissue layers, and limits the development of novel surgical techniques. We demonstrate multimodal swept-source spectrally encoded scanning laser ophthalmoscopy and optical coherence tomography (SS-SESLO-OCT) to address current limitations of image-guided ophthalmic microsurgery. SS-SESLO-OCT provides inherently co-registered en face and cross-sectional field-of-views (FOVs) at a line rate of 400 kHz and >2 GPix/s throughput. We show in vivo imaging of the anterior segment and retinal fundus of a healthy volunteer, and preliminary results of multi-volumetric mosaicking for ultrawide-field retinal imaging with 90° FOV. Additionally, a scan-head was rapid-prototyped with a modular architecture which enabled integration of SS-SESLO-OCT with traditional surgical microscope and slit-lamp imaging optics. Ex vivo surgical maneuvers were simulated in cadaveric porcine eyes. The system throughput enabled volumetric acquisition at 10 volumes-per-second (vps) and allowed visualization of surgical dynamics in corneal sweeps, compressions, and dissections, and retinal sweeps, compressions, and elevations. SESLO en face images enabled simple real-time co-registration with the surgical microscope FOV, and OCT cross-sections provided depth-resolved visualization of instrument-tissue interactions. Finally, we demonstrate novel augmented-reality integration with the surgical view using segmentation overlays to aid surgical guidance. SS-SESLO-OCT may benefit clinical diagnostics by enabling aiming, registration, and mosaicking; and intraoperative imaging by allowing for real-time surgical feedback, instrument tracking, and overlays of computationally extracted biomarkers of disease.

Proceedings Article | 17 February 2017 Presentation + Paper

Multi-volumetric registration and mosaicking using swept-source spectrally encoded scanning laser ophthalmoscopy and optical coherence tomography

Ivan Bozic, Mohamed El-Haddad, Joseph Malone, Karen Joos, Shriji Patel, Yuankai Tao

Proceedings Volume 10053, 1005326 (2017) https://doi.org/10.1117/12.2254859

KEYWORDS: Optical coherence tomography, Image registration, Scanning laser ophthalmoscopy, Diagnostics, Coherence imaging, Multimodal imaging, Ophthalmic imaging, Optical imaging, Eye, In vivo imaging, Data acquisition, Retinal scanning, Scanners

Read Abstract +

Proceedings Article | 8 February 2017 Paper

Longitudinal visualization of vascular occlusion, reperfusion, and remodeling in a zebrafish model of retinal vascular leakage using OCT angiography

Kathleen Spitz, Ivan Bozic, Vineet Desai, Gopikrishna Rao, Lana Pollock, Bela Anand-Apte, Yuankai Tao

Proceedings Volume 10045, 1004525 (2017) https://doi.org/10.1117/12.2252418

KEYWORDS: Optical coherence tomography, Animal model studies, Visual process modeling, Angiography, Pathogens, Visualization, Vascular imaging, Therapeutics, Organisms, Molecules, Eye, In vivo imaging, Functional imaging, Retinal scanning

Read Abstract +

Proceedings Article | 8 February 2017 Presentation + Paper

Automated feature extraction for retinal vascular biometry in zebrafish using OCT angiography

Ivan Bozic, Gopikrishna Rao, Vineet Desai, Yuankai Tao

Proceedings Volume 10045, 100450J (2017) https://doi.org/10.1117/12.2252370

KEYWORDS: Optical coherence tomography, Angiography, Feature extraction, Animal model studies, Image segmentation, Vascular imaging, In vivo imaging, Linear filtering, Optic nerve, Head, Eye, Biometrics, Genetics, Eye models

Read Abstract +

Showing 5 of 9 publications

View contact details

UPDATE YOUR PROFILE

Is this your profile? Update it now.

Sign into your SPIE.org account

Don’t have a profile and want one?

Create an account on SPIE.org

Keywords/Phrases

Search In:

Publication Years