Dr. Jacob Schmidt Profile

Dr. Jacob Schmidt

at Univ of California Los Angeles

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Proceedings Article | 29 August 2008 Paper

Automatable lipid bilayer formation for ion channel studies

Jason Poulos, Hyunwoo Bang, Tae-Joon Jeon, Jacob Schmidt

Proceedings Volume 7035, 703509 (2008) https://doi.org/10.1117/12.795375

KEYWORDS: Ion channels, Interfaces, Proteins, Electrodes, Capacitance, Molecules, Sensors, Microfluidics, Natural surfaces, Feedback control

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Transmembrane proteins and ion channels are important drug targets and have been explored as single molecule sensors. For these proteins to function normally they must be integrated within lipid bilayers; however, the labor and skill required to create artificial lipid bilayers have the limited the possible applications utilizing these proteins. In order to reduce the complexity and cost of lipid bilayer formation and measurement, we have modified a previously published lipid bilayer formation technique using mechanically contacted monolayers so that the process is automatable, requiring minimal operator input. Measurement electronics are integrated with the fluid handling system, greatly reducing the time and operator feedback characteristically required of traditional bilayer experiments. To demonstrate the biological functionality of the resultant bilayers and the system's capabilities as a membrane platform, the ion channel gramicidin A was incorporated and measured with this system.

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