Dr. Jens M. Steinbrink Profile

Dr. Jens M. Steinbrink

at Charité Universitätsmedizin Berlin

SPIE Involvement:

Author

SPIE Journal Paper | 10 September 2014 Open Access

Optimizing the regularization for image reconstruction of cerebral diffuse optical tomography

Christina Habermehl, Jens Steinbrink, Klaus-Robert Müller, Stefan Haufe

JBO, Vol. 19, Issue 09, 096006, (September 2014) https://doi.org/10.1117/12.10.1117/1.JBO.19.9.096006

KEYWORDS: Image restoration, Reconstruction algorithms, Brain, Data modeling, Phased arrays, Interference (communication), Brain activation, Absorption, Inverse problems, Head

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Functional near-infrared spectroscopy (fNIRS) is an optical method for noninvasively determining brain activation by estimating changes in the absorption of near-infrared light. Diffuse optical tomography (DOT) extends fNIRS by applying overlapping “high density” measurements, and thus providing a three-dimensional imaging with an improved spatial resolution. Reconstructing brain activation images with DOT requires solving an underdetermined inverse problem with far more unknowns in the volume than in the surface measurements. All methods of solving this type of inverse problem rely on regularization and the choice of corresponding regularization or convergence criteria. While several regularization methods are available, it is unclear how well suited they are for cerebral functional DOT in a semi-infinite geometry. Furthermore, the regularization parameter is often chosen without an independent evaluation, and it may be tempting to choose the solution that matches a hypothesis and rejects the other. In this simulation study, we start out by demonstrating how the quality of cerebral DOT reconstructions is altered with the choice of the regularization parameter for different methods. To independently select the regularization parameter, we propose a cross-validation procedure which achieves a reconstruction quality close to the optimum. Additionally, we compare the outcome of seven different image reconstruction methods for cerebral functional DOT. The methods selected include reconstruction procedures that are already widely used for cerebral DOT [minimum ℓ2-norm estimate (ℓ2MNE) and truncated singular value decomposition], recently proposed sparse reconstruction algorithms [minimum ℓ1- and a smooth minimum ℓ0-norm estimate (ℓ1MNE, ℓ0MNE, respectively)] and a depth- and noise-weighted minimum norm (wMNE). Furthermore, we expand the range of algorithms for DOT by adapting two EEG-source localization algorithms [sparse basis field expansions and linearly constrained minimum variance (LCMV) beamforming]. Independent of the applied noise level, we find that the LCMV beamformer is best for single spot activations with perfect location and focality of the results, whereas the minimum ℓ1-norm estimate succeeds with multiple targets.

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SPIE Journal Paper | 3 June 2013 Open Access

Effect of a mirror-like illusion on activation in the precuneus assessed with functional near-infrared spectroscopy

Jan Mehnert, Maddalena Brunetti, Jens Steinbrink, Michael Niedeggen, Christian Dohle

JBO, Vol. 18, Issue 06, 066001, (June 2013) https://doi.org/10.1117/12.10.1117/1.JBO.18.6.066001

KEYWORDS: Mirrors, Brain, Visualization, Near infrared spectroscopy, Video, Electroencephalography, Statistical analysis, Sensors, Functional magnetic resonance imaging, Hemodynamics

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SPIE Journal Paper | 4 May 2012 Open Access

Separation of indocyanine green boluses in the human brain and scalp based on time-resolved in-vivo fluorescence measurements

Alexander Jelzow, Heidrun Wabnitz, Rainer Macdonald, Hellmuth Obrig, Jens Steinbrink

JBO, Vol. 17, Issue 5, 057003, (May 2012) https://doi.org/10.1117/12.10.1117/1.JBO.17.5.057003

KEYWORDS: Brain, Luminescence, Indocyanine green, In vivo imaging, Tissues, Neuroimaging, Biomedical optics, Fluorescence spectroscopy, Picosecond phenomena, Signal to noise ratio

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Proceedings Article | 9 February 2012 Paper

Contrast-enhanced diffuse optical tomography of brain perfusion in humans using ICG

Christina Habermehl, Christoph Schmitz, Jens Steinbrink

Proceedings Volume 8207, 82074O (2012) https://doi.org/10.1117/12.905742

KEYWORDS: Brain, Near infrared spectroscopy, Absorption, Optical fibers, Skin, Sensors, Diffuse optical tomography, Tissue optics, Imaging systems

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Proceedings Article | 15 June 2011 Paper

Three-dimensional superposition of diffuse optical tomography results and subjacent anatomic structures

Christina Habermehl, Christoph Schmitz, Jan Mehnert, Susanne Holtze, Jens Steinbrink

Proceedings Volume 8088, 80880I (2011) https://doi.org/10.1117/12.889372

KEYWORDS: Head, Brain, Optical fibers, Near infrared spectroscopy, Finite element methods, Diffuse optical tomography, Brain mapping, Neuroimaging, Magnetic resonance imaging, Systems modeling

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SPIE Journal Paper | 1 November 2010 Open Access

Optical bedside monitoring of cerebral perfusion: technological and methodological advances applied in a study on acute ischemic stroke

Oliver Steinkellner, Clemens Gruber, Heidrun Wabnitz, Alexander Jelzow, Jens Steinbrink, Jochen Fiebach, Rainer Macdonald, Hellmuth Obrig

JBO, Vol. 15, Issue 06, 061708, (November 2010) https://doi.org/10.1117/12.10.1117/1.3505009

KEYWORDS: Targeting Task Performance metric, Luminescence, Ischemic stroke, Photons, Solids, Biomedical optics, Brain, Near infrared spectroscopy, Contamination, Independent component analysis

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SPIE Journal Paper | 1 July 2008 Open Access

Fluorescence tomography technique optimized for noninvasive imaging of the mouse brain

Riad Bourayou, Heide Boeth, Heval Benav, Thomas Betz, Ute Lindauer, Till Nierhaus, Jan Klohs, Andreas Wunder, Ulrich Dirnagl, Jens Steinbrink

JBO, Vol. 13, Issue 04, 041311, (July 2008) https://doi.org/10.1117/12.10.1117/1.2968262

KEYWORDS: Sensors, Brain, Monte Carlo methods, Tissues, Head, Optical properties, Fluorescence tomography, Tomography, Neuroimaging, Luminescence

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Proceedings Article | 15 October 2003 Paper

Functional brain imaging by CW-NIRS coregistered by blood flow monitors

Jens Steinbrink, Florian Kempf, Stephan Schreiber, Kamil Uludag, Matthias Kohl, Jose Valdueza, Arno Villringer, Hellmuth Obrig

Proceedings Volume 5138, (2003) https://doi.org/10.1117/12.500479

KEYWORDS: Near infrared spectroscopy, Blood circulation, Absorption, Brain, Blood, Visualization, Tissues, Doppler effect, Brain imaging, Blood pressure

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Proceedings Article | 15 October 2003 Paper

Intra- and extracerebral changes of hemoglobin concentrations by analysis of moments of distributions of times of flight of photons

Adam Liebert, Heidrun Wabnitz, Jens Steinbrink, Hellmuth Obrig, Michael Moeller, Rainer Macdonald, Herbert Rinneberg

Proceedings Volume 5138, (2003) https://doi.org/10.1117/12.500578

KEYWORDS: Absorption, Photons, Head, Tissues, Brain, Monte Carlo methods, Tissue optics, Optical properties, Visualization, Time metrology

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SPIE Journal Paper | 1 July 2002 Open Access

Noninvasive monitoring of cerebral blood flow by a dye bolus method: separation of brain from skin and skull signals

Matthias Kohl-Bareis, Hellmuth Obrig, Jens Steinbrink, Jasmin Malak, Kamil Uludag, Arno Villringer

JBO, Vol. 7, Issue 03, (July 2002) https://doi.org/10.1117/12.10.1117/1.1482719

KEYWORDS: Absorption, Signal attenuation, Tissue optics, Skin, Skull, Near infrared spectroscopy, Sensors, Tissues, Magnetic resonance imaging, Cerebral blood flow

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SPIE Journal Paper | 1 January 2002 Open Access

Crosstalk in the Lambert-Beer calculation for near-infrared wavelengths estimated by Monte simulations

Kamil Uludag, Matthias Kohl-Bareis, Jens Steinbrink, Hellmuth Obrig, Arno Villringer

JBO, Vol. 7, Issue 01, (January 2002) https://doi.org/10.1117/12.10.1117/1.1427048

KEYWORDS: Chromophores, Absorption, Tissues, Signal attenuation, Head, Optical spheres, Photons, Brain, Scattering, Monte Carlo methods

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Proceedings Article | 29 June 2001 Paper

Noninvasive cerebral blood flow monitoring by a dye bolus method:separation of extra- and intracerebral absorption changes by frequency-domain spectroscopy

Matthias Kohl-Bareis, Hellmuth Obrig, Jens Steinbrink, Jasmin Malak, Kamil Uludag, Arno Villringer

Proceedings Volume 4250, (2001) https://doi.org/10.1117/12.434501

KEYWORDS: Absorption, Tissue optics, Near infrared spectroscopy, Signal attenuation, Tissues, Spectroscopy, Skin, Skull, Signal detection, Magnetic resonance imaging

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Showing 5 of 12 publications

Conference Committee Involvement (2)

Diffuse Optical Imaging V

23 June 2015 | Munich, Germany

Diffuse Optical Imaging IV

12 May 2013 | Munich, Germany

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