To explore the damage range in the photothermal treatment at different temperatures, a temperature-feedback photothermal control system was developed. The system used an infrared thermal imager to noninvasively monitor the temperature .so it could avoid the damage caused by thermocouple measurement and apply the PID controller to achieve the desired temperature(1). the range of damage at the surface and the depth of internal damage were recorded at the different temperatures, which are based on the temperature-feedback photothermal control system. Finally, the recorded data are used to fit the curve by linear regression, and the damage depth was predicted according to the range of external damage at the surface. The technique could be a potential application for monitoring tumor treatment.
Photothermal therapy of tumors has become an important method. In recent years, the method has been widely studied in tumor therapy, and the corresponding results has been obtained well. However, it is still not been solved the effects of the heat on the tumor and its surrounding tissues, and the temperature control in corresponding tissues during the treatment process. In our study, the mouse skin was chosen as the research object. Infrared thermal imager and optical coherence tomography (OCT) were combined to monitor the photothermal therapy in real time in vivo. Temperature and morphological structure were obtained during the photothermal therapy process. The results will provide effective guidance for the photothermal therapy of tissue.