Mr. Jiaxing Song Profile

Jiaxing Song

at South China Normal Univ

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Proceedings Article | 6 March 2009 Paper

Effect of the prosurvival protein MCL-1 on photodynamic therapy induced apoptosis

Jiaxing Song, Yunlong Li, Yanchun Wei

Proceedings Volume 7280, 72801T (2009) https://doi.org/10.1117/12.822047

KEYWORDS: Photodynamic therapy, Cell death, Proteins, Confocal microscopy, Luminescence, Tumors, Cancer, Oncology, Colorectal cancer, Oxygen

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Photodynamic Therapy (PDT), a promising and approved therapeutics for neoplastic and vascular disease, could induce expression of angiogenic and survival molecules including vascular endothelial growth factor, cyclooxygenase-2 (COX-2), and MCL-1. However, the precise effect of MCL-1 which is a member of the bcl-2 family on PDT is not well characterized. The work described here was aimed at determining whether expression of MCL-1 could exhibit a side effect on PDT. The results showed that expression of MCL-1 was increased prominently after Hela cells treated with PDT. By using confocal fluorescence microscopy and cell viability assay, it was found that overexpression of MCL-1 could have a vital influence on Photofrin-PDT-mediated apoptosis. Moreover, further analyses indicated that MCL-1 delayed translocation of Bax and release of cytochrome c from mitochrondria, further leading to cause a delay in cell apoptosis in Hela cells treated with PDT. The process was associated with MCL-1 interaction directly with Bax. In conclusion, overexpression of MCL-1 plays an important part in efficiency of PDT killing tumor cells, in other words, MCL-1 overexpression decreases PDT induced apoptosis through directly interacting with Bax. These results suggest that targeting MCL-1 expression might be a highly effective therapeutic measure for promoting the tumoricidal effectiveness of PDT.

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