Dr. Jorge Plutzky Profile

Dr. Jorge Plutzky

at Brigham and Womens Hospital

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Author

Publications (5)

SPIE Journal Paper | 12 September 2024 Open Access

Enhanced peripheral tissue oxygenation and hemoglobin concentration after a high-fat meal measured with spatial frequency domain imaging

Anahita Pilvar, Jorge Plutzky, Darren Roblyer

BIOS, Vol. 1, Issue 02, 025004, (September 2024) https://doi.org/10.1117/12.10.1117/1.BIOS.1.2.025004

KEYWORDS: Tissues, Blood, Blood pressure, Optical properties, Oxygenation, Hemodynamics, Glucose, Biomedical optics, Heart, Scattering

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SignificanceThe magnitude and temporal dynamics of changes in blood nutrient and lipid levels following a high-fat meal have been previously shown to be an important indicator of current and future cardiovascular health and disease. Measurement of circulating nutrients and lipids currently requires invasive blood draws. The development of a non-invasive method for continuous monitoring of postprandial (i.e., after-meal) changes may assist in enhancing cardiovascular health management, dietary monitoring, and identification of disease-promoting factors. Spatial frequency domain imaging (SFDI) is a non-contact, label-free optical technique that can quantify tissue optical properties and hemodynamics in vivo. We hypothesized that SFDI may track the postprandial state in peripheral tissue.AimWe aim to investigate the relationship between postprandial factors, namely triglycerides and glucose, and the optical properties and oxygenation of peripheral tissue measured with SFDI.ApproachFifteen healthy volunteers consumed both a low- (2 g) and high- (60 g) fat meal on different days. A custom SFDI device was used to measure the dorsal hand surface of volunteers before the meal and each hour for 5 h after the meal. Measurements were taken at 730, 880, and 1100 nm. Longitudinal postprandial changes in tissue optical properties were correlated with changes in blood triglycerides and glucose levels as well as blood pressure, heart rate, and room temperature. A machine-learning model was trained to estimate triglyceride levels from SFDI metrics.ResultsSeveral SFDI metrics increased and peaked 3 to 4 h following the high-fat meal, including tissue oxygen saturation (StO2) and oxyhemoglobin (HbO2) concentration, and were substantially different from the low-fat cohort (p<0.05 at 3 h). The increases were large, >5% for StO2 and >10% for HbO2 concentration on average. The temporal changes in these metrics broadly tracked triglyceride levels, which peaked at 3 h post-meal. The predictive model accurately estimated blood triglyceride levels (RMSE 40 mg/dL).ConclusionThese findings suggest that SFDI could serve as a powerful non-invasive tool to monitor postprandial hemodynamics. In the future, SFDI measurements may help enhance cardiovascular disease prediction and management.

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SPIE Journal Paper | 8 June 2023 Open Access

Feasibility of postprandial optical scattering of lipoproteins in blood as an optical marker of cardiovascular disease risk: modeling and experimental validation

Anahita Pilvar, Declan Smith, Jorge Plutzky, Darren Roblyer

JBO, Vol. 28, Issue 06, 065002, (June 2023) https://doi.org/10.1117/12.10.1117/1.JBO.28.6.065002

KEYWORDS: Blood, Particles, Mie scattering, Scattering, Simulations, Refractive index, Optical properties, Red blood cells, Plasma, Chemical vapor deposition

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Proceedings Article | 7 March 2023 Presentation

Scattering and hemodynamic changes after a high-fat meal measured with SFDI

Anahita Pilvar, Declan Smith, Thomas Livecchi, Mark Pierce, Jorge Plutzky, Darren Roblyer

Proceedings Volume PC12376, PC123760L (2023) https://doi.org/10.1117/12.2650724

KEYWORDS: Short wave infrared radiation, Scattering, Blood, Hemodynamics, Shortwaves, Mie scattering, Infrared radiation, Infrared imaging, Tissue optics, Particles

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SPIE Journal Paper | 17 June 2022 Open Access

Shortwave infrared spatial frequency domain imaging for non-invasive measurement of tissue and blood optical properties

Anahita Pilvar, Jorge Plutzky, Mark Pierce, Darren Roblyer

JBO, Vol. 27, Issue 06, 066003, (June 2022) https://doi.org/10.1117/12.10.1117/1.JBO.27.6.066003

KEYWORDS: Short wave infrared radiation, Optical properties, Skin, Tissue optics, Spatial frequencies, Blood, Infrared radiation, Infrared imaging, Shortwaves, Scattering

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Proceedings Article | 7 March 2022 Presentation

Clinic-ready shortwave infrared spatial frequency domain imaging (SWIR SFDI) system for non-invasive monitoring of postprandial blood lipids

Anahita Pilvar, Mark Pierce, Jorge Plutzky, Darren Roblyer

Proceedings Volume PC11944, PC119440H (2022) https://doi.org/10.1117/12.2608185

KEYWORDS: Short wave infrared radiation, Imaging systems, Blood, Shortwaves, Infrared radiation, Infrared imaging, Blood vessels, Tissue optics, Optical properties, Chemical vapor deposition

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