Ms. Karolina Papera Valente Profile

Karolina Papera Valente

PhD Student

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Proceedings Article | 4 March 2019 Presentation + Paper

Merging micro and nano: study of transport of gold nanoparticles inside a tumor microenvironment-on-a-chip

Karolina Valente, Sapanbir Thind, Afzal Suleman, Alexandre Brolo

Proceedings Volume 10875, 108750S (2019) https://doi.org/10.1117/12.2509193

KEYWORDS: Diffusion, Microfluidics, Nanoparticles, Tumors, Tissues, Gold, Cancer, Ultraviolet radiation

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Transport of chemotherapeutic drugs through tissues happens by convection and diffusion. In a normal healthy tissue, capillary vessels are highly pressurized when compared to the tissue interstitial pressure. Therefore, nutrients and drug molecules move from blood vessels to the healthy cells with the aid of capillary pressure. In the case of cancerous tissue, accelerated cell growth within normal cells in addition to disorganized blood vessel network limits the transport of nutrients and drug molecules to mainly diffusion. This happens due to the combination of high tumor interstitial fluid pressure and extracellular matrix (ECM) stiffening, resulting in a decrease of efficacy of delivery of drugs. This work investigated the use of hydrogel in order to mimic the tumor microenvironment in a microfluidic system. A hydrogel matrix was injected inside of a microfluidic device in order to mimic the extracellular matrix of a cancerous tissue. In addition, this work evaluated the transport of gold nanoparticles inside the microfluidic system, by tracking fluorescence.

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