Optics and light-based technology are becoming more and more important as a cross-field of new science and engineering, and the scope of optics education should be extended. Since 2018, in Zhejiang University a new wave of general education reform has started, and our course Light-based Science and Technologies and Human Civilization has become a common core course. In the last 3 years our students mainly come from science and engineering, only a few students come from social science. From now on we will offer this course to multidisciplinary students, especially the students of politics, economics, law and arts. In this paper we present our learning organization, especially the group discussion in multidisciplinary students. The students from different specialties are divided into one group. The discussion topics are about research methodology, famous arguments in optics history, optics in daily life and imagination of the future.
Non-invasive deep tissue imaging and focusing is highly demanded in biomedical research. However, for in vivo applications, the major challenge is the limited imaging depth, a of random scattering in biological tissue causing exponential attenuation of the ballistic component the light wave. Here we present the optical focusing with diffraction-limited resolution deep inside highly scattering media by using machine learning. Compared with conventional adaptive optics, method can not only provide high-speed sensor-less wavefront measurement with more than 90% accuracy, but also dramatically reduce photobleaching and photodamage. This technology paves the way for many important applications in fundamental biology research, especially in neuroscience.
The refractive index heterogeneity severely limits the imaging performance of optical microscopy in deep tissue. Adaptive optics (AO) is currently widely used to recover the diffraction-limited resolution at depth. However, there is a tradeoff between the time resolution and spatial resolution, which makes it difficult to achieve the real-time imaging in deep tissue. This is partially because that the effective correction area of conventional AO is limited with a single guide star (GS). Therefore, the using of multiple guide stars is a potential solution to increase the corrected field of view. Here we report an automatic selection algorithm of multiple guide stars and demonstrate the feasibility by implementing this method in the system of conjugate adaptive optical correction with multiple GSs. The simulation results indicate that compared with the case of the single guide star, high-resolution imaging can be obtained in most imaging areas with automatically selected 9 guide stars. Further, we can obtain optimally numbers and positions of the guide stars automatically and expect larger area aberrations. Therefore, this method has the great potential in in vivo deep tissue imaging.
Starting from 2015, a general education course named “Light-based science and technologies and human civilization” has been offered in Zhejiang University. We try to give a humanism view angle to observe optics and optical engineering, and combine them with the relationship of human and the nature, the development of human society and human health. In this course we introduce different historical periods of light-based science and technologies, the great optical researchers, the typical research methods, advantages, academic discussions and the relationship with human civilization. The relevant cross-fields of learning and Nobel Prize winners are also included. This course provides the students with the typical examples about how academic revolution influences the world development, and also with humanism sight which exceeds the range of science and technologies themselves.
Access to the requested content is limited to institutions that have purchased or subscribe to SPIE eBooks.
You are receiving this notice because your organization may not have SPIE eBooks access.*
*Shibboleth/Open Athens users─please
sign in
to access your institution's subscriptions.
To obtain this item, you may purchase the complete book in print format on
SPIE.org.