Dr. Kin F. Chan Profile

Dr. Kin F. Chan

Co-founder/CTO

SPIE Involvement:

Conference Chair | Conference Program Committee | Editor | Author

Area of Expertise:

Laser Tissue Interaction , Tissue Optics , Laser & Optical Engineering , Measurement & Automation , Wound Healing , Preclinical & Clinical

Profile Summary

https://www.researchgate.net/profile/Kin_Chan5

Publications (25)

Proceedings Article | 7 March 2021 Presentation

Deep learning based quantification of cutaneous drug uptake from standard epi-fluorescence microscopy

Conor Evans, Maiko Hermsmeier, Kin Chan

Proceedings Volume 11624, 116240J (2021) https://doi.org/10.1117/12.2577350

KEYWORDS: Skin, Microscopy, Luminescence, Fluorescence lifetime imaging, Tissues, Neural networks, Convolutional neural networks

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Proceedings Article | 5 March 2021 Presentation

Welcome and Introduction to SPIE Conference 11624

Conor Evans, Kin Chan

Proceedings Volume 11624, 1162402 (2021) https://doi.org/10.1117/12.2593324

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Proceedings Article | 5 March 2019 Paper

Multimodal microscopy toolkit for visualizing multicomponent topical drug formulations in humans

Alexander Fast, Sinyoung Jeong, Maiko Hermsmeier, Akira Yamamoto, Xin Chen, Kin Chan, Conor Evans

Proceedings Volume 10882, 108822J (2019) https://doi.org/10.1117/12.2510157

KEYWORDS: Tissues, Fluorescence lifetime imaging, Visualization, Skin, Raman spectroscopy, Microscopy, Confocal microscopy, Absorption, Multiphoton tomography, Natural surfaces

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Proceedings Article | 4 March 2019 Presentation

Fluorescence lifetime imaging microscopy along with non-Euclidean phasor analysis for visualization of drug distribution of a topical drug in human facial skin (Conference Presentation)

Sinyoung Jeong, Alexander Fast, Sam Osseiran, Maiko Hermsmeier, Tanvee Sawant, Kin Chan, Conor Evans

Proceedings Volume 10859, 1085908 (2019) https://doi.org/10.1117/12.2510218

KEYWORDS: Skin, Visualization, Fluorescence lifetime imaging, Visual analytics, Microscopy, Luminescence

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Proceedings Article | 14 March 2018 Presentation

Phasor approach to fluorescence lifetime imaging microscopy for visualization and quantification of drug distribution of a topical minocycline gel in human facial skin (Conference Presentation)

Sinyoung Jeong, Maiko Hermsmeier, Sam Osseiran, Akira Yamamoto, Usha Nagavarapu, Kin Chan, Conor Evans

Proceedings Volume 10475, 104750I (2018) https://doi.org/10.1117/12.2290898

KEYWORDS: Fluorescence lifetime imaging, Visualization, Skin, Microscopy, Tissues, Luminescence, Biological research, Molecules, Image visualization, Visual analytics

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Proceedings Article | 14 March 2018 Presentation

Effects of endogenous fluorescence from ex vivo human facial skin specimens in the pharmacokinetic study of a topical minocycline gel using two-photon excitation fluorescence (2PEF) and fluorescence lifetime imaging microscopy (FLIM) (Conference Presentation)

Maiko Hermsmeier, Sinyoung Jeong, Akira Yamamoto, Xin Chen, Usha Nagavarapu, Conor Evans, Kin Chan

Proceedings Volume 10475, 104750H (2018) https://doi.org/10.1117/12.2294403

KEYWORDS: Skin, Luminescence, Fluorescence lifetime imaging, Microscopy, Integrating spheres, Tissues, Microscopes, Safety, Drug development, Objectives

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Proceedings Article | 14 March 2018 Presentation

Fluorescence lifetime imaging microscopy (FLIM) for visualization of targeted drug delivery and local distribution in skin of a single daily dose of topical minocycline gel: an update on translational research from preclinical to clinical (Conference Presentation)

Sinyoung Jeong, Maiko Hermsmeier, Sam Osseiran, Akira Yamamoto, Xin Chen, Usha Nagavarapu, Conor Evans, Kin F. Chan, AnnaMarie Daniels

Proceedings Volume 10467, 104670J (2018) https://doi.org/10.1117/12.2294084

KEYWORDS: Fluorescence lifetime imaging, Microscopy, Luminescence, Skin, Visualization, Translational research, Pharmacology, Toxicology, Nonlinear optics

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Proceedings Article | 19 April 2017 Presentation

Visualization of drug distribution of topical minocycline in human facial skin with fluorescence microscopy (Conference Presentation)

Maiko Hermsmeier, Tanvee Sawant, Diana Lac, Akira Yamamoto, Xin Chen, Usha Nagavarapu, Conor Evans, Kin Foong Chan

Proceedings Volume 10046, 100460A (2017) https://doi.org/10.1117/12.2256621

KEYWORDS: Luminescence, Visualization, Microscopy, Skin, Tissues, Bacteria, Inflammation, Photomedicine, Current controlled current source

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Proceedings Article | 19 April 2017 Presentation

Optical microscopy of targeted drug delivery and local distribution in skin of a topical minocycline: implications in translational research and guidance for therapeutic dose selection (Conference Presentation)

Maiko Hermsmeier, Tanvee Sawant, Diana Lac, Akira Yamamoto, Xin Chen, Susan Huang, Usha Nagavarapu, Conor Evans, Kin Foong Chan, AnnaMarie Daniels

Proceedings Volume 10037, 100370K (2017) https://doi.org/10.1117/12.2256790

KEYWORDS: Skin, Luminescence, Microscopy, Safety, Optical microscopy, Translational research, In vitro testing, Molecules, Toxicity, Vehicle control

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SPIE Journal Paper | 1 November 2010 Open Access

Immunohistochemical evaluation of the heat shock response to nonablative fractional resurfacing

Basil Hantash, Vikramaditya Bedi, Steven Struck, Kin Chan

JBO, Vol. 15, Issue 06, 068002, (November 2010) https://doi.org/10.1117/12.10.1117/1.3526355

KEYWORDS: Skin, Proteins, Collagen, Cell death, Wound healing, Tissues, In vivo imaging, Injuries, Laser therapeutics, Human subjects

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SPIE Journal Paper | 1 March 2010 Open Access

Femtosecond laser lithotripsy: feasibility and ablation mechanism

Jinze Qiu, Joel Teichman, Tianyi Wang, Joseph Neev, Randolph Glickman, Kin Foong Chan, Thomas Milner

JBO, Vol. 15, Issue 02, 028001, (March 2010) https://doi.org/10.1117/12.10.1117/1.3368998

KEYWORDS: Laser ablation, Femtosecond phenomena, Calculi, Plasma, Calculus, Laser lithotripsy, Pulsed laser operation, Laser therapeutics, Ferroelectric polymers, Photography

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SPIE Journal Paper | 1 March 2009 Open Access

In vivo confocal imaging of epidermal cell migration and dermal changes post nonablative fractional resurfacing: study of the wound healing process with corroborated histopathologic evidence

Oliver Stumpp, Vikramaditya Bedi, Danica Wyatt, Diana Lac, Zakia Rahman, Kin-Foong Chan

JBO, Vol. 14, Issue 02, 024018, (March 2009) https://doi.org/10.1117/12.10.1117/1.3103316

KEYWORDS: Confocal microscopy, Tissues, Wound healing, In vivo imaging, Statistical analysis, Tissue optics, Skin, Collagen, Biopsy, Microscopes

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SPIE Journal Paper | 1 July 2006 Open Access

Laser-induced transepidermal elimination of dermal content by fractional photothermolysis

Basil Hantash, Vikramaditya Bedi, Vasanthi Sudireddy, Steven Struck, G. Scott Herron, Kin Foong Chan

JBO, Vol. 11, Issue 04, 041115, (July 2006) https://doi.org/10.1117/12.10.1117/1.2241745

KEYWORDS: Skin, Laser therapeutics, Pulsed laser operation, Tissues, Strontium vapor lasers, Collagen, Fiber lasers, Laser systems engineering, Laser tissue interaction, Wound healing

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The wound healing process in skin is studied in human subjects treated with fractional photothermolysis. In-vivo histological evaluation of vacuoles formed over microthermal zones (MTZs) and their content is undertaken. A 30-W, 1550-nm single-mode fiber laser system delivers an array of 60 µm or 140 µm 1/e2 incidence microbeam spot size at variable pulse energy and density. Treatments span from 6 to 20 mJ with skin excisions performed 1-day post-treatment. Staining with hematoxylin and eosin demonstrates an intact stratum corneum with vacuolar formation within the epidermis. The re-epithelialization process with repopulation of melanocytes and keratinocytes at the basal layer is apparent by 1-day post-treatment. The dermal-epidermal (DE) junction is weakened and separated just above zones of dermal coagulation. Complete loss of dermal cell viability is noted within the confines of the MTZs 1-day post-treatment, as assessed by lactate dehydrogenase. All cells falling outside the irradiation field remain viable. Content within the epidermal vacuoles stain positively with Gomori trichrome, suggesting a dermal origin. However, the positive staining could be due to loss of specificity after thermal alteration. Nevertheless, this dermal extrusion hypothesis is supported by very specific positive staining with an antihuman elastin antibody. Fractional photothermolysis creates microthermal lesions that allow transport and extrusion of dermal content through a compromised DE junction. Some dermal material is incorporated into the microepidermal necrotic debris and shuttled up the epidermis to eventually be exfoliated through the stratum corneum. This is the first report of a nonablative laser-induced transport mechanism by which dermal content can be predictably extruded biologically through the epidermis. Thus, treatment with the 1550-nm fiber laser may provide the first therapeutic option for clinical indications, including pigmentary disorders such as medically recalcitrant melasma, solar elastosis, as well as ...

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SPIE Journal Paper | 1 October 2003

High-resolution maskless lithography

Kin Foong Chan, Zhiqiang Feng, Ren Yang, Akihito Ishikawa, WenHui Mei

JM3, Vol. 2, Issue 04, (October 2003) https://doi.org/10.1117/12.10.1117/1.1611182

KEYWORDS: Digital micromirror devices, Maskless lithography, Lithography, Microlens array, Glasses, Photomasks, Scanning electron microscopy, Photoresist materials, Microelectromechanical systems, LCDs

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SPIE Journal Paper | 1 July 2003

Design and fabrication of microlens and spatial filter array by self-alignment for maskless lithography systems

Ren Yang, Kin Foong Chan, Zhiqiang Feng, Ishikawa Akihito, WenHui Mei

JM3, Vol. 2, Issue 03, (July 2003) https://doi.org/10.1117/12.10.1117/1.1584445

KEYWORDS: Microlens array, Microlens, Spatial filters, Digital micromirror devices, Maskless lithography, Glasses, Photoresist materials, Lithography, Chromium, Micromirrors

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Proceedings Article | 20 January 2003 Paper

High-resolution maskless lithography by the integration of micro-optics and point array technique

Kin Foong Chan, Zhiqiang Feng, Ren Yang, Wenhui Mei

Proceedings Volume 4985, (2003) https://doi.org/10.1117/12.472856

KEYWORDS: Digital micromirror devices, Maskless lithography, Semiconductors, Glasses, Photomasks, Scanning electron microscopy, Micro optics, Lithography, Light sources, Lens design

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Proceedings Article | 20 January 2003 Paper

Design and fabrication of microlens and spatial filter array by self-alignment

Ren Yang, Kin Foong Chan, Zhiqiang Feng, Wenhui Mei

Proceedings Volume 4985, (2003) https://doi.org/10.1117/12.472865

KEYWORDS: Microlens array, Microlens, Glasses, Maskless lithography, Digital micromirror devices, Spatial filters, Photoresist materials, Metals, Lithography, Semiconductors

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Proceedings Article | 13 June 2000 Paper

In-vitro Erbium:YAG laser lithotripsy

Kin Foong Chan, Gracie Vargas, Patricia Parker, Joel Teichman, Randolph Glickman, H. Stan McGuff, Ashley Welch

Proceedings Volume 3914, (2000) https://doi.org/10.1117/12.388046

KEYWORDS: Er:YAG lasers, Calculus, Acoustics, Sapphire, Laser lithotripsy, Plasma, Fiber lasers, Pulsed laser operation, Laser therapeutics, Laser energy

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Proceedings Article | 17 May 2000 Paper

Use of osmotically active agents to alter optical properties of tissue: influence on the detected fluorescence signal from a subsurface target

Gracie Vargas, Kin Foong Chan, Sharon Thomsen, Ashley Welch

Proceedings Volume 3907, (2000) https://doi.org/10.1117/12.386242

KEYWORDS: Signal detection, Tissue optics, Skin, Luminescence, Scattering, Tissues, In vitro testing, In vivo imaging, Optical properties, Fluorescence spectroscopy

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Proceedings Article | 28 April 2000 Paper

Influence of optical absorption on urinary calculus threshold fluence and ablation efficiency during infrared laser ablation

Kin Foong Chan, Daniel Hammer, Bernard Choi, Gracie Vargas, Brian Sorg, T. Joshua Pfefer, Joel Teichman, H. Stan McGuff, Hans Pratisto, E. Duco Jansen, Ashley Welch

Proceedings Volume 3925, (2000) https://doi.org/10.1117/12.384253

KEYWORDS: Laser ablation, Absorption, Calculi, Laser damage threshold, Tissue optics, Calculus, Absorbance, Hard tissue optics, Free electron lasers, Infrared radiation

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Proceedings Article | 17 September 1999 Paper

Photothermal ablation is the primary mechanism in holmium:YAG laser lithotripsy of urinary calculi

Randolph Glickman, Joel Teichman, Nicole Corbin, George Vassar, Susan Weintraub, Kin Foong Chan, Ashley Welch

Proceedings Volume 3863, (1999) https://doi.org/10.1117/12.364416

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Proceedings Article | 14 June 1999 Paper

Chemical decomposition of urinary stones during holmium-laser lithotripsy: II. Evidence for photothermal breakdown

Randolph Glickman, Joel Teichman, George Vassar, Susan Weintraub, Kin Foong Chan, T. Joshua Pfefer, Ashley Welch

Proceedings Volume 3601, (1999) https://doi.org/10.1117/12.350022

KEYWORDS: Laser ablation, Magnesium, Cyanide, Calcium, Laser energy, Calculi, Pulsed laser operation, Absorption, Laser therapeutics, Chemical analysis

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Proceedings Article | 14 June 1999 Paper

Chemical decomposition of urinary stones during holmium-laser lithotripsy: I. Lack of a photomechanical effect

Kin Foong Chan, George Vassar, T. Joshua Pfefer, Joel Teichman, Randolph Glickman, Susan Weintraub, Ashley Welch

Proceedings Volume 3601, (1999) https://doi.org/10.1117/12.350023

KEYWORDS: Holmium, Acoustics, Pulsed laser operation, Laser energy, Laser therapeutics, Laser lithotripsy, Photography, Cavitation, Calculus, Fiber lasers

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Proceedings Article | 13 May 1998 Paper

Fluorescence-based temperature measurement in laser-induced vapor bubbles

Kin Foong Chan, T. Joshua Pfefer, Daniel Hammer, E. Duco Jansen, Martin Frenz, Ashley Welch

Proceedings Volume 3254, (1998) https://doi.org/10.1117/12.308174

KEYWORDS: Temperature metrology, Pulsed laser operation, Luminescence, Fiber lasers, Optical fibers, Infrared radiation, Photography, Spatial resolution, Spherical lenses, Laser irradiation

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Proceedings Article | 13 May 1998 Paper

Pulsed holmium:YAG-induced thermal damage in albumen

T. Joshua Pfefer, Kin Foong Chan, Daniel Hammer, Ashley Welch

Proceedings Volume 3254, (1998) https://doi.org/10.1117/12.308164

KEYWORDS: Pulsed laser operation, Absorption, Data modeling, Optical simulations, Laser scattering, Thermal modeling, Diffusion, Thermography, Tissues, Tissue optics

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Showing 5 of 25 publications

Proceedings Volume Editor (10)

SPIE Conference Volume | 1 April 2024

Visualizing and Quantifying Drug Distribution in Tissue VIII

SPIE Conference Volume | 21 April 2023

Visualizing and Quantifying Drug Distribution in Tissue VII

SPIE Conference Volume | 28 March 2022

Visualizing and Quantifying Drug Distribution in Tissue VI

SPIE Conference Volume | 23 April 2021

Visualizing and Quantifying Drug Distribution in Tissue V

SPIE Conference Volume | 4 March 2020

Visualizing and Quantifying Drug Distribution in Tissue IV

Showing 5 of 10 publications

Conference Committee Involvement (21)

Advanced Photonics in Urology 2025

25 January 2025 | San Francisco, California, United States

Visualizing and Quantifying Drug Distribution in Tissue IX

25 January 2025 | San Francisco, California, United States

Advanced Photonics in Urology 2024

27 January 2024 | San Francisco, California, United States

Visualizing and Quantifying Drug Distribution in Tissue VIII

27 January 2024 | San Francisco, California, United States

Advanced Photonics in Urology 2023

28 January 2023 | San Francisco, California, United States

Visualizing and Quantifying Drug Distribution in Tissue VII

28 January 2023 | San Francisco, California, United States

Visualizing and Quantifying Drug Distribution in Tissue VI

22 January 2022 | San Francisco, California, United States

Visualizing and Quantifying Drug Distribution in Tissue V

6 March 2021 | Online Only, California, United States

Advanced Photonics in Urology

6 March 2021 | Online Only, California, United States

Therapeutics and Diagnostics in Urology 2020

1 February 2020 | San Francisco, California, United States

Visualizing and Quantifying Drug Distribution in Tissue IV

1 February 2020 | San Francisco, California, United States

Therapeutics and Diagnostics in Urology 2019

2 February 2019 | San Francisco, California, United States

Visualizing and Quantifying Drug Distribution in Tissue III

2 February 2019 | San Francisco, California, United States

Therapeutics and Diagnostics in Urology 2018

27 January 2018 | San Francisco, California, United States

Visualizing and Quantifying Drug Distribution in Tissue II

27 January 2018 | San Francisco, California, United States

Therapeutics and Diagnostics in Urology

28 January 2017 | San Francisco, California, United States

Visualizing and Quantifying Drug Distribution in Tissue

28 January 2017 | San Francisco, California, United States

Therapeutics and Diagnostics in Urology

13 February 2016 | San Francisco, California, United States

Therapeutics and Diagnostics in Urology

7 February 2015 | San Francisco, California, United States

Therapeutics and Diagnostics in Urology

1 February 2014 | San Francisco, California, United States

Therapeutics and Diagnostics in Urology: Lasers, Robotics, Minimally Invasive, and Advanced Biomedical Devices

2 February 2013 | San Francisco, California, United States

Showing 5 of 21 Conference Committees

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