Mr. Kyle B. Cutler Profile

Kyle B. Cutler

Graduate Student Researcher at Univ of California Irvine

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Author

Publications (2)

SPIE Journal Paper | 13 August 2021 Open Access

Multi-modal diffuse optical spectroscopy for high-speed monitoring and wide-area mapping of tissue optical properties and hemodynamics

Jesse Lam, Brian Hill, Timothy Quang, Robert Amelard, Sehwan Kim, Hossein Yazdi, Robert Warren, Kyle Cutler, Bruce Tromberg

JBO, Vol. 26, Issue 08, 085002, (August 2021) https://doi.org/10.1117/12.10.1117/1.JBO.26.8.085002

KEYWORDS: Tissues, Hemodynamics, Tissue optics, Data acquisition, Diffuse optical spectroscopy, Oxygen, Optical properties, Imaging systems, Semiconductor lasers, In vivo imaging

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Significance: Diffuse optical spectroscopic imaging (DOSI) is a versatile technology sensitive to changes in tissue composition and hemodynamics and has been used for a wide variety of clinical applications. Specific applications have prompted the development of versions of the DOSI technology to fit specific clinical needs. This work describes the development and characterization of a multi-modal DOSI (MM-DOSI) system that can acquire metabolic, compositional, and pulsatile information at multiple penetration depths in a single hardware platform. Additionally, a 3D tracking system is integrated with MM-DOSI, which enables registration of the acquired data to the physical imaging area. Aim: We demonstrate imaging, layered compositional analysis, and metabolism tracking capabilities using a single MM-DOSI system on optical phantoms as well as in vivo human tissue. Approach: We characterize system performance with a silicone phantom containing an embedded object. To demonstrate multi-layer sensitivity, we imaged human calf tissue with a 4.8-mm skin-adipose thickness. Human thenar tissue was also measured using a combined broadband DOSI and continuous-wave near-infrared spectroscopy method (∼15 Hz acquisition rate). Results: High-resolution optical property maps of absorption (μa) and reduced scattering (μs ′ ) were recovered on the phantom by capturing over 1000 measurement points in under 5 minutes. On human calf tissue, we show two probing depth layers have significantly different (p < 0.001) total-hemo/myoglobin and μs ′ composition. On thenar tissue, we calculate tissue arterial oxygen saturation, venous oxygen saturation, and tissue metabolic rate of oxygen consumption during baseline and after release of an arterial occlusion. Conclusions: The MM-DOSI can switch between collection of broadband spectra, high-resolution images, or multi-depth hemodynamics without any hardware reconfiguration. We conclude that MM-DOSI enables acquisition of high resolution, multi-modal data consolidated in a single platform, which can provide a more comprehensive understanding of tissue hemodynamics and composition for a wide range of clinical applications.

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SPIE Journal Paper | 20 December 2017 Open Access

Noninvasive optical imaging of resistance training adaptations in human muscle

Robert Warren, Joshua Cotter, Goutham Ganesan, Lisa Le, Janelle Agustin, Bridgette Duarte, Kyle Cutler, Thomas O'Sullivan, Bruce Tromberg

JBO, Vol. 22, Issue 12, 121611, (December 2017) https://doi.org/10.1117/12.10.1117/1.JBO.22.12.121611

KEYWORDS: Dual energy x-ray absorptiometry, Tissues, Near infrared spectroscopy, Optical imaging, Resistance, Tissue optics, Spectroscopy, Imaging spectroscopy, Capillaries, Absorption

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