Dr. Leonid Zubkov Profile

Dr. Leonid Zubkov

Sr. Research Associate at Drexel Univ

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Publications (10)

Proceedings Article | 17 May 2018 Presentation + Paper

The temporal correlation transfer simulation in a tissue model with anisotropic scattering patterns for the blood flow analyses

A. Yu. Valkov, L. Zubkov, V. Kuzmin

Proceedings Volume 10685, 106851Y (2018) https://doi.org/10.1117/12.2314541

KEYWORDS: Roentgenium, Modulation, Phase shift keying

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The diffuse correlation spectroscopy (DCS) and diffuse near infrared spectroscopy (DNIRS) are the contemporary non-invasive optical methods which have turned out now to be ones of the most required optical tools for assessing tissue health, in regards to mammography, brain, and deep tissue injury. Earlier we reported on an observation, within the DCS technics, of development of pressure injuries measuring dermal and subcutaneous red blood cell motion; the data obtained has produced remarkably a characteristic decay time of the light intensity temporal correlation function being five times larger for patients of the group with developing open pressure injuries as compared with the group exhibiting healthier stage. The quantitative determination of the characteristic time required a definite picture of scatterer motion. For quantitative study the crucial problem to solve is a proper account for the scattering anisotropy. We perform comparative simulations of the diffuse photon density wave (DPDW) signals and the temporal intensity correlation functions either with the Henyey-Greenstein (HG) or Rayleigh-Gans (RG) phase functions, which we consider is more appropriate as the hard sphere suspension model for imitating a tissue. We find that for a half space geometry the results obtained for these two scattering patterns turn to be quite close; however for finite size tissue geometries results of simulations of the source-detector plot for backscattered intensity differ noticeably at small distances; simulating the temporal correlation function with these two phase functions we find the blood flow to be different for different scattering patterns in case of spatial restrictions. The DPDW methodology is widely used in a number of biomedical applications. Here we present results of Monte Carlo simulations that employ an effective numerical procedure, based upon a description of radiative transfer in terms of the Bethe-Salpeter equation, and compare them with measurements from Intralipid aqueous solutions. We find the Monte Carlo simulations and measurements to be in a very good agreement for a wide range of source-detector separations.

SPIE Journal Paper | 11 February 2017 Open Access

Pressure injury prediction using diffusely scattered light

David Diaz, Alec Lafontant, Michael Neidrauer, Michael Weingarten, Rose Ann DiMaria-Ghalili, Ericka Scruggs, Julianne Rece, Guy Fried, Vladimir Kuzmin, Leonid Zubkov

JBO, Vol. 22, Issue 02, 025003, (February 2017) https://doi.org/10.1117/12.10.1117/1.JBO.22.2.025003

KEYWORDS: Tissue optics, Injuries, Polonium, Light scattering, Tissues, Blood circulation, Diffusion, Sensors, Skin, Optical fibers

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Proceedings Article | 4 March 2016 Paper

Assessment of sacrococcygeal pressure ulcers using diffuse correlation spectroscopy

Rose Ann DiMaria-Ghalili, Guy Fried, Peter Lewin, Leonid Zubkov, David Diaz, Michael Neidrauer, Michael Weingarten, Alec Lafontant, Julianne Rece

Proceedings Volume 9715, 97150M (2016) https://doi.org/10.1117/12.2212980

KEYWORDS: Spectroscopy, Tissue optics, Blood circulation, Tissues, Light scattering, Oxygen, Metabolism, Injuries, Capillaries, Correlation function, Skin, Optical fibers, Blood, Scattering

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SPIE Journal Paper | 14 October 2015 Open Access

Diffuse photon density wave measurements and Monte Carlo simulations

Vladimir Kuzmin, Michael Neidrauer, David Diaz, Leonid Zubkov

JBO, Vol. 20, Issue 10, 105006, (October 2015) https://doi.org/10.1117/12.10.1117/1.JBO.20.10.105006

KEYWORDS: Monte Carlo methods, Scattering, Sensors, Diffusion, Modulation, Diffuse photon density waves, Anisotropy, Signal detection, Photon transport, Tissues

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Proceedings Article | 22 May 2015 Paper

20 kHz ultrasound assisted treatment of chronic wounds with concurrent optic monitoring

Peter Lewin, Christopher Bawiec, Youhan Sunny, Michael Weingarten, Leonid Zubkov, David Margolis, Michael Neidrauer, David Diaz, Sumati Nadkarni

Proceedings Volume 9467, 94670E (2015) https://doi.org/10.1117/12.2083508

KEYWORDS: Ultrasonography, Wound healing, Tissue optics, Blood circulation, Tissues, Medicine, In vitro testing, Diagnostics, Spectroscopes, Capillaries

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Proceedings Article | 6 March 2015 Paper

Diffuse photon density wave measurements in comparison with the Monte Carlo simulations

V. Kuzmin, D. Diaz, M. Neidrauer, L. Zubkov

Proceedings Volume 9325, 93250E (2015) https://doi.org/10.1117/12.2084723

KEYWORDS: Scattering, Monte Carlo methods, Diffusion, Sensors, Modulation, Light scattering, Anisotropy, Photon transport, Radiative transfer, Tissue optics

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Proceedings Article | 27 February 2014 Paper

Development of a multi-frequency diffuse photon density wave device for the characterization of tissue damage at multiple depths

David Diaz, Michael Weingarten, Joshua Samuels, Richard Huneke, Peter Lewin, Leonid Zubkov, Michael Neidrauer, Vladimir Kuzmin

Proceedings Volume 8935, 89351K (2014) https://doi.org/10.1117/12.2040095

KEYWORDS: Tissue optics, Modulation, Scattering, Phase shifts, Tissues, Absorption, Sensors, Optical properties, Light scattering, Actuators

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SPIE Journal Paper | 1 November 2009 Open Access

Noninvasive assessment of diabetic foot ulcers with diffuse photon density wave methodology: pilot human study

Elisabeth Papazoglou, Michael Neidrauer, Leonid Zubkov, Michael Weingarten, Kambiz Pourrezaei

JBO, Vol. 14, Issue 06, 064032, (November 2009) https://doi.org/10.1117/12.10.1117/1.3275467

KEYWORDS: Wound healing, Diabetic foot ulcers, Tissue optics, Absorption, Diffuse photon density waves, Near infrared, Skin, Digital photography, Optical fibers, Oxygen

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SPIE Journal Paper | 1 July 2008 Open Access

Changes in optical properties of tissue during acute wound healing in an animal model

Elisabeth Papazoglou, Michael Weingarten, Leonid Zubkov, Michael Neidrauer, Linda Zhu, Som Tyagi, Kambiz Pourrezaei

JBO, Vol. 13, Issue 04, 044005, (July 2008) https://doi.org/10.1117/12.10.1117/1.2960952

KEYWORDS: Wound healing, Tissue optics, Optical properties, Absorption, Animal model studies, Near infrared spectroscopy, Tissues, Scattering, Surgery, Diffusion

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Proceedings Article | 22 February 2008 Paper

Noninvasive quantitative assessment of diabetic wounds with diffuse photon density wave technology

Michael Neidrauer, Kambiz Pourrezaei, Linda Zhu, Michael Weingarten, Elisabeth Papazoglou, Leonid Zubkov

Proceedings Volume 6863, 68630L (2008) https://doi.org/10.1117/12.766518

KEYWORDS: Wound healing, Absorption, Tissue optics, Near infrared, Tissues, Surgery, Diffuse photon density waves, Blood, Optical properties, Scattering

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Showing 5 of 10 publications

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