Dr. Liang Song Profile

Dr. Liang Song

Professor at Shenzhen Institutes of Advanced Technology

SPIE Involvement:

Author

Publications (24)

SPIE Journal Paper | 17 April 2024 Open Access

Influence mechanism of the temporal duration of laser irradiation on photoacoustic technique: a review

Rongkang Gao, Yan Liu, Sumin Qi, Liang Song, Jing Meng, Chengbo Liu

JBO, Vol. 29, Issue S1, S11530, (April 2024) https://doi.org/10.1117/12.10.1117/1.JBO.29.S1.S11530

KEYWORDS: Pulse signals, Pulsed laser operation, Laser frequency, Biomedical optics, Absorption, Acoustic waves, Thermography, Image resolution, Signal detection, Acoustics

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Proceedings Article | 20 November 2019 Paper

Carotid atherosclerosis detection using photoacoustic imaging system

Zhihua Xie, Chengyou Shu, Xiaojing Gong, Liang Song

Proceedings Volume 11190, 111902T (2019) https://doi.org/10.1117/12.2537649

KEYWORDS: Inflammation, Photoacoustic imaging, Arteries, In vivo imaging, Blood, Photoacoustic spectroscopy, Imaging systems, Light scattering, Laser scattering, Oxygen

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Carotid arteries are important channels delivering blood and oxygen to brain. Atherosclerosis plaque in carotid arteries hinders blood delivery, and plaque rupture causes stroke, leading to high morbidity and motility. Extensive preclinical and clinical studies showed that atherosclerosis inflammation activities are highly related to plaque vulnerability. Thus, visualizing the inflammation of atherosclerosis plaques is important in atherosclerosis vulnerability assessment. In this study, photoacoustic imaging modality was applied for carotid atherosclerosis inflammation identification of mouse in vivo. Deficient apolipoprotein E (ApoE-/-) mice with high-fat diet and normal diet for 16 weeks were employed as atherosclerosis models and control models, respectively. Photoacoustic molecular probes with optical absorption at nearinfrared wavelength and specifically target cluster of differentiation 36 (CD36) were employed to mark inflammation cells in carotid atherosclerosis plaques of mouse in vivo. Noninvasive imaging of atherosclerosis inflammation cells marked by molecular probes was performed by point-to-point scanning with a custom-built acoustic-resolution photoacoustic imaging system. Considering low scattering of near-infrared light in tissues and mature commercialization of laser, excitation wavelength in this research is chosen at 1064 nm. Carotid arteries with and without atherosclerosis plaques have been noninvasively imaged and distinguished. Furthermore, carotid atherosclerosis with different inflammation severity has been analyzed by photoacoustic imaging and immunohistochemistry staining. Photoacoustic signal from atherosclerosis arteries showed high relativity with inflammation severity defined by immunohistochemistry staining, evidencing the reliability of the novel imaging technology in atherosclerosis inflammation identification. This study paves the way for photoacoustic imaging technology to atherosclerosis inflammation identification, severity quantification and even further atherosclerosis therapy.

Proceedings Article | 20 November 2019 Paper

High-speed intravascular photoacoustic imaging with blood flushing

Chengyou Shu, Zhihua Xie, Daya Yang, Zhiyi Chen, Liang Song, Xiaojing Gong

Proceedings Volume 11190, 111901V (2019) https://doi.org/10.1117/12.2537147

KEYWORDS: Imaging systems, Photoacoustic spectroscopy, High speed imaging, In vivo imaging, Inflammation, Blood, Photoacoustic imaging, Laser development, Intravascular ultrasound, Metals

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SPIE Journal Paper | 24 September 2018 Open Access

Compact and low-cost handheld quasibright-field linear-array probe design in photoacoustic computed tomography

Yuanyuan Bai, Bing Cong, Xiaojing Gong, Liang Song, Chengbo Liu

JBO, Vol. 23, Issue 12, 121606, (September 2018) https://doi.org/10.1117/12.10.1117/1.JBO.23.12.121606

KEYWORDS: Photoacoustic spectroscopy, Ultrasonography, Transducers, Prostate, Photoacoustic tomography, Acoustics, Signal to noise ratio, Laser energy, Imaging systems, Signal detection

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SPIE Journal Paper | 8 May 2018 Open Access

Dual-foci detection in photoacoustic computed tomography with coplanar light illumination and acoustic detection: a phantom study

Xiangwei Lin, Chengbo Liu, Jing Meng, Xiaojing Gong, Riqiang Lin, Mingjian Sun, Liang Song

JBO, Vol. 23, Issue 05, 050501, (May 2018) https://doi.org/10.1117/12.10.1117/1.JBO.23.5.050501

KEYWORDS: Transducers, Photoacoustic tomography, Acoustics, Signal detection, Imaging systems, Signal to noise ratio, Data acquisition, Quartz, Ultrasonics, Sensors

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SPIE Journal Paper | 23 April 2018 Open Access

Three-dimensional Hessian matrix-based quantitative vascular imaging of rat iris with optical-resolution photoacoustic microscopy in vivo

Huangxuan Zhao, Guangsong Wang, Riqiang Lin, Xiaojing Gong, Liang Song, Tan Li, Wenjia Wang, Kunya Zhang, Xiuqing Qian, Haixia Zhang, Lin Li, Zhicheng Liu, Chengbo Liu

JBO, Vol. 23, Issue 04, 046006, (April 2018) https://doi.org/10.1117/12.10.1117/1.JBO.23.4.046006

KEYWORDS: Algorithm development, 3D image processing, Iris recognition, Iris, Vascular imaging, Blood vessels, Image processing, Photoacoustic imaging, In vivo imaging, Imaging systems

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Proceedings Article | 30 March 2017 Paper

Full field-of-view photoacoustic endoscopy in vivo

Riqiang Lin, Yan Li, Jianhua Chen, Liang Song

Proceedings Volume 10064, 100643Y (2017) https://doi.org/10.1117/12.2251402

KEYWORDS: Endoscopy, In vivo imaging, Photoacoustic spectroscopy, Imaging systems, Rectum, Biomedical optics, Chemical oxygen iodine lasers, Endoscopes, Ultrasonics, 3D image processing

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SPIE Journal Paper | 18 July 2016 Open Access

High-speed, sparse-sampling three-dimensional photoacoustic computed tomography in vivo based on principal component analysis

Jing Meng, Zibo Jiang, Lihong Wang, Jongin Park, Chulhong Kim, Mingjian Sun, Yuanke Zhang, Liang Song

JBO, Vol. 21, Issue 07, 076007, (July 2016) https://doi.org/10.1117/12.10.1117/1.JBO.21.7.076007

KEYWORDS: Principal component analysis, Photoacoustic tomography, Transducers, Image restoration, Data acquisition, CT reconstruction, Photoacoustic spectroscopy, 3D image processing, 3D image reconstruction, Image processing

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Proceedings Article | 27 April 2016 Presentation

Fully integrated reflection-mode photoacoustic/two-photon microscopy in vivo (Conference Presentation)

Liang Song, Wei Song, Yang Zhang, Wei Zheng

Proceedings Volume 9708, 97082H (2016) https://doi.org/10.1117/12.2214685

KEYWORDS: In vivo imaging, Imaging systems, Microscopy, Ultrasonics, Transducers, Photoacoustic microscopy, Two photon excitation microscopy, Biomedical optics, Image resolution, Collagen

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SPIE Journal Paper | 28 March 2016 Open Access

Delay-multiply-and-sum-based synthetic aperture focusing in photoacoustic microscopy

Jongin Park, Seungwan Jeon, Jing Meng, Liang Song, Jin Lee, Chulhong Kim

JBO, Vol. 21, Issue 03, 036010, (March 2016) https://doi.org/10.1117/12.10.1117/1.JBO.21.3.036010

KEYWORDS: Signal to noise ratio, Photoacoustic microscopy, In vivo imaging, Signal processing, Image resolution, Acoustics, Image processing, Signal detection, Transducers, Carbon

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Proceedings Article | 15 March 2016 Paper

Optimization of the image reconstruction procedure in multi-focal photoacoustic computed tomography

Hongying Wan, Depeng Wang, Jing Meng, Liang Song, Leslie Ying, Jun Xia

Proceedings Volume 9708, 970840 (2016) https://doi.org/10.1117/12.2215001

KEYWORDS: Compressed sensing, Tissue optics, Microscopy, Image restoration, Photoacoustic microscopy, Photoacoustic tomography, Photoacoustic spectroscopy, New and emerging technologies, Absorption, Photoacoustic imaging, Transducers, Data acquisition, Reconstruction algorithms, Microlens array, Image resolution, Signal to noise ratio, Imaging systems

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SPIE Journal Paper | 22 June 2015 Open Access

High-speed intravascular spectroscopic photoacoustic imaging at 1000 A-lines per second with a 0.9-mm diameter catheter

Yan Li, Xiaojing Gong, Chengbo Liu, Riqiang Lin, William Hau, Xiaosong Bai, Liang Song

JBO, Vol. 20, Issue 06, 065006, (June 2015) https://doi.org/10.1117/12.10.1117/1.JBO.20.6.065006

KEYWORDS: Photoacoustic spectroscopy, Spectroscopy, Imaging spectroscopy, Imaging systems, Photoacoustic imaging, Intravascular ultrasound, Absorption, Optical parametric oscillators, Laser energy, Image resolution

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SPIE Journal Paper | 5 March 2014 Open Access

Compressed sensing based virtual-detector photoacoustic microscopy in vivo

Jing Meng, Chengbo Liu, Jiaxiang Zheng, Riqiang Lin, Liang Song

JBO, Vol. 19, Issue 03, 036003, (March 2014) https://doi.org/10.1117/12.10.1117/1.JBO.19.3.036003

KEYWORDS: In vivo imaging, Sensors, Photoacoustic microscopy, Ultrasonics, Photoacoustic spectroscopy, Transducers, Compressed sensing, Image quality, Biomedical optics, Image restoration

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Proceedings Article | 3 March 2014 Paper

Integrated intravascular ultrasound and optical-resolution photoacoustic microscopy with a 1-mm-diameter catheter

Xiaosong Bai, Xiaojing Gong, Riqiang Lin, William Hau, Liang Song

Proceedings Volume 8943, 894308 (2014) https://doi.org/10.1117/12.2037017

KEYWORDS: Intravascular ultrasound, Photoacoustic spectroscopy, Imaging systems, Image resolution, Photoacoustic imaging, Ultrasonics, Photoacoustic microscopy, Tissue optics, Integrated optics, Ultrasonography

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Proceedings Article | 18 February 2011 Paper

Photoacoustic image-guided needle biopsy of sentinel lymph nodes

Chulhong Kim, Todd Erpelding, Walter Akers, Konstantin Maslov, Liang Song, Ladislav Jankovic, Julie Margenthaler, Samuel Achilefu, Lihong Wang

Proceedings Volume 7899, 78990K (2011) https://doi.org/10.1117/12.874956

KEYWORDS: Lymphatic system, Biopsy, Photoacoustic spectroscopy, Ultrasonography, In vivo imaging, Imaging systems, Breast, Luminescence, Photoacoustic imaging, Medicine

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SPIE Journal Paper | 1 July 2010 Open Access

Handheld array-based photoacoustic probe for guiding needle biopsy of sentinel lymph nodes

Chulhong Kim, Todd Erpelding, Konstantin Maslov, Ladislav Jankovic, Walter Akers, Liang Song, Samuel Achilefu, Julie Margenthaler, Michael Pashley, Lihong Wang

JBO, Vol. 15, Issue 04, 046010, (July 2010) https://doi.org/10.1117/12.10.1117/1.3469829

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SPIE Journal Paper | 1 March 2010 Open Access

Ultrasound-array-based real-time photoacoustic microscopy of human pulsatile dynamics in vivo

Liang Song, Konstantin Maslov, K. Kirk Shung, Lihong Wang

JBO, Vol. 15, Issue 02, 021303, (March 2010) https://doi.org/10.1117/12.10.1117/1.3333545

KEYWORDS: Imaging systems, Photoacoustic spectroscopy, In vivo imaging, Skin, Arteries, Photoacoustic microscopy, Real time imaging, Photoacoustic imaging, Ultrasonography, Tissue optics

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SPIE Journal Paper | 1 March 2010 Open Access

Compressed sensing in photoacoustic tomography in vivo

Zijian Guo, Changhui Li, Liang Song, Lihong Wang

JBO, Vol. 15, Issue 02, 021311, (March 2010) https://doi.org/10.1117/12.10.1117/1.3381187

KEYWORDS: Acquisition tracking and pointing, Photoacoustic tomography, In vivo imaging, Data acquisition, Compressed sensing, Sensors, Reconstruction algorithms, Ultrasonics, Tomography, Wavelets

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Proceedings Article | 24 February 2010 Paper

Ultrasound array photoacoustic microscopy for dynamic in vivo 3D imaging

Liang Song, Konstantin Maslov, K. Kirk Shung, Lihong Wang

Proceedings Volume 7564, 756403 (2010) https://doi.org/10.1117/12.840582

KEYWORDS: In vivo imaging, Imaging systems, Stereoscopy, Ultrasonography, 3D image processing, Photoacoustic microscopy, 3D modeling, Lymphatic system, Temporal resolution, Biomedical optics

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Proceedings Article | 11 February 2010 Paper

Compressed sensing in photoacoustic tomography with in vivo experiments

Zijian Guo, Changhui Li, Liang Song, Lihong Wang

Proceedings Volume 7564, 75640J (2010) https://doi.org/10.1117/12.841311

KEYWORDS: Acquisition tracking and pointing, Photoacoustic tomography, Data acquisition, In vivo imaging, CT reconstruction, Reconstruction algorithms, Tomography, Compressed sensing, Sensors, Ultrasonics

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Proceedings Article | 25 February 2009 Paper

Fast 3-D photoacoustic imaging in vivo with a high frequency ultrasound array toward clinical applications

Liang Song, Konstantin Maslov, Rachel Bitton, K. Kirk Shung, Lihong Wang

Proceedings Volume 7177, 71770G (2009) https://doi.org/10.1117/12.809013

KEYWORDS: Imaging systems, Ultrasonography, Photoacoustic imaging, In vivo imaging, 3D image processing, Skin, Stereoscopy, Visualization, Tissue optics, Photoacoustic microscopy

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SPIE Journal Paper | 1 September 2008 Open Access

Fast 3-D dark-field reflection-mode photoacoustic microscopy in vivo with a 30-MHz ultrasound linear array

Liang Song, Konstantin Maslov, Rachel Bitton, K. Kirk Shung, Lihong Wang

JBO, Vol. 13, Issue 05, 054028, (September 2008) https://doi.org/10.1117/12.10.1117/1.2976141

KEYWORDS: Imaging systems, Ultrasonography, Photoacoustic microscopy, 3D image processing, Photoacoustic imaging, 3D photoacoustic microscopy, In vivo imaging, Photoacoustic spectroscopy, Stereoscopy, Skin

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Proceedings Article | 29 February 2008 Paper

Realtime photoacoustic microscopy of murine cardiovascular and respiratory dynamics in vivo

Roger Zemp, Liang Song, Rachel Bitton, K. Kirk Shung, Lihong Wang

Proceedings Volume 6856, 68560G (2008) https://doi.org/10.1117/12.763127

KEYWORDS: Imaging systems, Ultrasonography, Photoacoustic imaging, Visualization, Photoacoustic spectroscopy, Transducers, Photoacoustic microscopy, In vivo imaging, Heart, Data acquisition

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Proceedings Article | 1 June 1990 Paper

Potential role of collagen in optical behavior of arterial tissue during laser irradiation

Ramtin Agah, Massoud Motamedi, Praveen Dalmia, Emile Ettedgui, Liang Song, J. Richard Spears

Proceedings Volume 1202, (1990) https://doi.org/10.1117/12.17633

KEYWORDS: Tissue optics, Laser tissue interaction, Collagen, Tissues, Optical properties, Laser irradiation, Scattering, Thermography, Absorption, Rayleigh scattering

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Showing 5 of 24 publications

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