Dr. Lin Yang Profile

Dr. Lin Yang

Scientist at Physikalisch-Technische Bundesanstalt

SPIE Involvement:

Author

Area of Expertise:

Quantitative Analysis , Computational Physics , Diffuse Optics , Laser Spectroscopy , Numerical Simulation , Optimization

PhD in Physics | Marie Curie Fellow | Scientist in computational diffuse optics & quantitative analysis

SPIE Journal Paper | 15 June 2022 Open Access

Multi-laboratory performance assessment of diffuse optics instruments: the BitMap exercise

Pranav Lanka, Lin Yang, David Orive-Miguel, Joshua Deepak Veesa, Susanna Tagliabue, Aleh Sudakou, Saeed Samaei, Mario Forcione, Zuzana Kovacsova, Anurag Behera, Thomas Gladytz, Dirk Grosenick, Lionel Hervé, Turgut Durduran, Karolina Bejm, Magdalena Morawiec, Michał Kacprzak, Piotr Sawosz, Anna Gerega, Adam Liebert, Antonio Belli, Ilias Tachtsidis, Frédéric Lange, Gemma Bale, Luca Baratelli, Sylvain Gioux, Alexander Kalyanov, Martin Wolf, Sanathana Konugolu-Venkata-Sekar, Marta Zanoletti, Ileana Pirovano, Michele Lacerenza, Lina Qiu, Edoardo Ferocino, Giulia Maffeis, Caterina Amendola, Lorenzo Colombo, Lorenzo Frabasile, Pietro Levoni, Mauro Buttafava, Marco Renna, Laura Di Sieno, Rebecca Re, Andrea Farina, Lorenzo Spinelli, Alberto Dalla Mora, Davide Contini, Paola Taroni, Alberto Tosi, Alessandro Torricelli, Hamid Dehghani, Heidrun Wabnitz, Antonio Pifferi

JBO, Vol. 27, Issue 07, 074716, (June 2022) https://doi.org/10.1117/12.10.1117/1.JBO.27.7.074716

KEYWORDS: Raster graphics, Optical properties, Diffuse optical imaging, Scattering, Imaging spectroscopy, Absorption, Tissue optics, Spectroscopes, Sensors, Oximetry

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Proceedings Article | 5 March 2021 Presentation + Paper

A multi-laboratory comparison of photon migration instruments and their performances: the BitMap exercise

Sri Rama Pranav Kumar Lanka, Lin Yang, David Orive-Miguel, Joshua Deepak Veesa, Susanna Tagliabue, Aleh Sudakou, Saeed Samaei, Mario Forcione, Zuzana Kovacsova, Anurag Behera, Thomas Gladytz, Dirk Grosenick, Lionel Hervé, Giuseppe Lo Presti, Lorenzo Cortese, Turgut Durduran, Karolina Bejm, Magdalena Morawiec, Piotr Sawosz, Michal Kacprzak, Anna Gerega, Adam Liebert, Antonio Belli, Ilias Tachtsidis, Frédéric Lange, Gemma Bale, Luca Baratelli, Sylvain Gioux, Alexander Kalyanov, Martin Wolf, Sanathana Konugolu Venkata Sekar, Marta Zanoletti, Ileana Pirovano, Michele Lacerenza, Lina Qiu, Edoardo Ferocino, Giulia Maffeis, Caterina Amendola, Lorenzo Colombo, Mauro Buttafava, Marco Renna, Laura Di Sieno, Rebecca Re, Andrea Farina, Lorenzo Spinelli, Alberto Dalla Mora, Davide Contini, Alessandro Torricelli, Alberto Tosi, Paola Taroni, Hamid Dehghani, Heidrun Wabnitz, Antonio Pifferi

Proceedings Volume 11639, 116390F (2021) https://doi.org/10.1117/12.2578521

KEYWORDS: Raster graphics, Photonic devices, Tissue optics, Spectroscopes, Oximetry, Optical components, Mammography, Imaging spectroscopy, Functional imaging

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Proceedings Article | 5 March 2021 Presentation + Paper

Depth selectivity in time-domain fNIRS by analyzing moments and time windows

Aleh Sudakou, Heidrun Wabnitz, Lin Yang, Davide Contini, Lorenzo Spinelli, Alessandro Torricelli, Adam Liebert

Proceedings Volume 11639, 116390Q (2021) https://doi.org/10.1117/12.2578518

KEYWORDS: Photons, Absorption, Time metrology, Near infrared spectroscopy, Interference (communication), Brain

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Proceedings Article | 5 March 2021 Presentation

Accurate characterization of phantoms for performance assessment and calibration in diffuse optics

Heidrun Wabnitz, Lin Yang, Thomas Gladytz, Lina Hacker, James Joseph, Dirk Grosenick

Proceedings Volume 11633, 1163306 (2021) https://doi.org/10.1117/12.2588994

KEYWORDS: Diffuse optical imaging, Optical calibration, Calibration, Spatial light modulators, Reflectivity, Optical properties, Monte Carlo methods, Transmittance, Spectroscopes, Solids

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Proceedings Article | 11 July 2019 Paper

The BitMap dataset: an open dataset on performance assessment of diffuse optics instruments

David Orive-Miguel, Pranav Lanka, Lin Yang, Susanna Tagliabue, Aleh Sudakou, Saeed Samaei, Joshua Deepak Veesa, Mario Forcione, Zuzana Kovacsova, Anurag Behera, Lionel Hervé, Turgut Durduran, Adam Liebert, Piotr Sawosz, Antonio Belli, Ilias Tachtsidis, Alberto Dalla Mora, Jérôme Mars, Laurent Condat, Alessandro Torricelli, Hamid Dehghani, Heidrun Wabnitz, Antonio Pifferi

Proceedings Volume 11074, 110741B (2019) https://doi.org/10.1117/12.2526728

KEYWORDS: Diffuse optical imaging, Spectrometers, Oximeters, Transparency, Standards development, Biomedical engineering

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Proceedings Article | 11 July 2019 Paper

The BITMAP exercise: a multi-laboratory performance assessment campaign of diffuse optical instrumentation

Pranav Lanka, Lin Yang, David Orive-Miguel, Joshua Deepak Veesa, Susanna Tagliabue, Aleh Sudakou, Saeed Samaei, Mario Forcione, Zuzana Kovacsova, Anurag Behera, Lionel Hervé, Turgut Durduran, Adam Liebert, Piotr Sawosz, Antonio Belli, Ilias Tachtsidis, Alberto Dalla Mora, Hamid Dehghani, Heidrun Wabnitz, Antonio Pifferi

Proceedings Volume 11074, 110741A (2019) https://doi.org/10.1117/12.2527120

KEYWORDS: Optical instrument design, Spectroscopy, Oximeters, Standards development, Biomedical engineering, Diffuse optical imaging, Absorption, Scattering

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Proceedings Article | 11 July 2019 Paper

Spatially-enhanced time-domain NIRS for determination of optical properties in layered structures

Lin Yang, Pranav Lanka, Heidrun Wabnitz, Rinaldo Cubeddu, Thomas Gladytz, Sanathana Konugolu Venkata Sekar, Dirk Grosenick, Antonio Pifferi, Rainer Macdonald

Proceedings Volume 11074, 110740A (2019) https://doi.org/10.1117/12.2527032

KEYWORDS: Absorption, Near infrared spectroscopy, Optical properties, Scattering, Monte Carlo methods, Tissue optics, Tissues, Brain

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Proceedings Article | 4 March 2019 Presentation

Noise reduction and compression of Monte-Carlo lookup tables by singular value decomposition (Conference Presentation)

Thomas Gladytz, Heidrun Wabnitz, Lin Yang, Dirk Grosenick

Proceedings Volume 10870, 1087005 (2019) https://doi.org/10.1117/12.2506035

KEYWORDS: Monte Carlo methods, Denoising, Optical properties, Modeling, Near infrared spectroscopy, Statistical modeling, Absorption, Interference (communication), Smoothing, Sensors

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Proceedings Article | 27 February 2019 Paper

Digital phantom for time-domain near-infrared spectroscopy of tissue: concept and proof-of-principle experiments

Heidrun Wabnitz, Lin Yang, Rainer Macdonald, Jeeseong Hwang

Proceedings Volume 10870, 108700K (2019) https://doi.org/10.1117/12.2510405

KEYWORDS: Optical fibers, Spatial light modulators, Tissues, Tissue optics, Picosecond phenomena, Oximeters, Near infrared spectroscopy, Optical phantoms

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In the clinically relevant field of tissue oximetry, there is an urgent need to develop phantom-based methods for validation. Physical phantom approaches based on solid or liquid turbid media containing hemoglobin with variable oxygenation have limited capabilities to represent real tissues regarding optical properties, structure and variability. Digital phantoms are an alternative with high flexibility. Rather than physically simulating the process of light propagation, they provide the detector with light signals mimicking the signals detected in vivo. We present a technique to produce digital phantoms for time-domain diffuse optical spectroscopy that mimic arbitrary photon time-of-flight distributions (DTOFs) by creating a time-dependent attenuation. The setup contains a spatial light modulator (SLM) and a set of optical fibers of different lengths corresponding to a stepwise delay. The light pulse entering the arrangement is spatially dispersed and illuminates the SLM which controls the intensity at each pixel. The SLM array is imaged onto the entrance faces of the delay fibers. The amount of photons received by each individual fiber can be adjusted. Finally, the light transmitted through all fibers are combined and fed to the detector of the timedomain instrument under test. In this way, DTOFs of any desired shape can be obtained. For first proof-of-principle experiments to demonstrate the general feasibility of the concept we used a liquid-crystal SLM and a set of four graded-index fibers differing in length by about 100 mm. The tests were performed with a timedomain instrument based on time-correlated single photon counting, with picosecond diode and supercontinuum laser sources and a single-photon avalanche diode as well as a hybrid photomultiplier as detectors. This large separation in fiber lengths allowed the performance regarding amplitude and temporal shape to be assessed for each delay independently. The generation of arbitrary DTOFs was simulated by realizing various patterns of target amplitudes. Temporal position and width of the measured pulse profiles for all fibers were in agreement with the expectations. Amplitude linearity was reasonable while the contrast between highest and lowest amplitude values was not yet satisfactory. Steps of further development are discussed.

Proceedings Article | 16 March 2017 Paper

Broadband spectral measurements of diffuse optical properties by an integrating sphere instrument at the National Institute of Standards and Technology

Paul Lemaillet, Jeeseong Hwang, Heidrun Wabnitz, Dirk Grosenick, Lin Yang, David Allen

Proceedings Volume 10056, 1005604 (2017) https://doi.org/10.1117/12.2263338

KEYWORDS: Indium oxide, Scattering, Optical properties, Integrating spheres, Reflectivity, Transmittance, Standards development, Optical testing, Optical spheres, Solids

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Proceedings Article | 15 March 2017 Paper

Polydimethylsiloxane tissue-mimicking phantoms for quantitative optical medical imaging standards

Jeeseong Hwang, Hyun-Jin Kim, Paul Lemaillet, Heidrun Wabnitz, Dirk Grosenick, Lin Yang, Thomas Gladytz, David McClatchy, David Allen, Kimberly Briggman, Brian Pogue

Proceedings Volume 10056, 1005603 (2017) https://doi.org/10.1117/12.2263379

KEYWORDS: Scattering, Particles, Confocal microscopy, Tissue optics, Light scattering, Integrating spheres, Tissues, Reflectivity, Standards development, Backscatter

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