Dr. Luis Rivas Profile

Dr. Luis Rivas

at Ctr. de Investigaciones Biologicas

SPIE Involvement:

Author

Publications (1)

This will count as one of your downloads.

You will have access to both the presentation and article (if available).

DOWNLOAD NOW

This content is available for download via your institution's subscription. To access this item, please sign in to your personal account.

Email or Username Forgot your username?

Password Forgot your password?

Show

Keep me signed in

No SPIE account? Create an account

Proceedings Article | 7 August 2019 Paper

Self-sterilizing photoactivated catheters to prevent nosocomial infections

F. Amaro, M. Gómez-Mendoza, A. Descalzo, L. Rivas, G. Orellana

Proceedings Volume 11070, 110708C (2019) https://doi.org/10.1117/12.2525896

KEYWORDS: Bacteria, Oxygen, Medicine, Microorganisms, In vitro testing, Semiconductor lasers, Photodynamic therapy

Read Abstract +

Bacterial colonization and biofilm formation on catheters are the primary causes of nosocomial infections and entails a limitation for their long-term use, often requiring catheter removal. Ca. 80% of the urinary tract infections contracted by patients in hospitals are catheter-associated, leading to substantial morbidity, mortality and higher costs. The increase of multi-drug resistant bacteria has created an urgent need for new strategies to prevent biofilm formation on catheters and antimicrobial photodynamic inactivation (aPDI) appears to be a promising approach. We have developed (patent pending) self-sterilizing silicone catheters with a covalently attached layer of photosensitizer (PS) that shows strong antibacterial effect in vitro against a panel of bacterial species commonly related to catheter-associated infections such as Pseudomonas aeruginosa and Staphylococcus epidermidis. Illumination with a 532 nm diode laser light of the PSderivatized catheter surfaces induced killing of 99-99.9% of the bacterial biofilm attached to it. The population survival decreased to a negligible level after 60 min of illumination and no significant decrease of the bacterial viability was observed in the absence of either light or PS. Time-resolved luminescence measurements with detection at 1265 nm confirmed generation of singlet molecular oxygen (¹O₂) only in PS-derivatized catheters upon illumination, paving the way for future applications to reduce the occurrence of catheter-associated urinary tract infections.

My Library

You currently do not have any folders to save your paper to! Create a new folder below.

Folder Name

Folder Description

View contact details

UPDATE YOUR PROFILE

Is this your profile? Update it now.

Sign into your SPIE.org account

Don’t have a profile and want one?

Create an account on SPIE.org

Access to the requested content is limited to institutions that have purchased or subscribe to SPIE eBooks. You are receiving this notice because your organization may not have SPIE eBooks access.*

*Shibboleth/Open Athens users─please sign in to access your institution's subscriptions.

To obtain this item, you may purchase the complete book in print or electronic format on SPIE.org.

ORGANIZATIONAL
Sign in with credentials provided by your organization.

Organizational Username

Organizational Password

Show/Hide Password

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available

Members:

Non-members: ADD TO CART

Keywords/Phrases

Search In:

Publication Years