Bovine brucellosis is an infectious illness caused mainly by Brucella abortus that may affect domestic and wild animals. Accurate and fast diagnosis is critical for disease control and eradication. Thus, we have identified Brucella abortus antibodies in bovine serum by exploring the agglutination process that is carried out when positive samples are mixed with the antigen. In this case, when placed above the on-chip integrated waveguide, the reaction led to scattering spots that indicated the positive serum. The monitoring was performed through optical images over time and analyzed by artificial neural network. Classification models were able to differentiate the positive from the negative samples with 81.25% accuracy. This work may represent a breakthrough for the diagnosis of other infectious diseases.
We present an axially tapered large mode area W-fiber for high peak power femtosecond pulse propagation at 1550-nm wavelength. Our numerical simulations show pulse compression with output pulse of 36 kW peak power and 81 fs duration in down-tapered case and nearly undistorted propagation of 20 kW, 150 fs pulse in up-tapered case. Such direction dependent propagation of the pulse in the fiber should find applications in high power laser systems.
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