In this study, we demonstrate the potential manufacturing method and application of 2D WSe2-based field-effect transistors (2D-FETs) as a promising biosensor for the selective and rapid detection of a pathogen such as SARS-CoV-2 in vitro. The sensors are manufactured by first synthesizing 2D material on Si/SiO2 substrates, followed by photolithography processes to form the FET devices. Then, the surface of 2D material WSe2 has been functionalized with a specific antibody to selectively detect the SARS-CoV-2 spike protein. The TMDC-based 2D-FETs can potentially serve as sensitive and selective biosensors for the rapid detection of infectious diseases.
In this study, we demonstrate the potential application of 2D monolayer WSe2-based field-effect transistors (2D-FETs) as a promising biosensor for the selective and rapid detection of SARS-CoV-2 in vitro. The sensors are manufactured by first growing the 2D crystals on Si/SiO2 substrates, followed by photolithography processes to form the FET devices. WSe2 crystals are then functionalized with a specific antibody to selectively detect the SARS-CoV-2 spike protein. We demonstrate a detection limit of down to 25 fg/μL in 0.01 PBS. The TMDC-based 2D-FETs can potentially serve as sensitive and selective biosensors for the rapid detection of infectious diseases.
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