Prof. Marissa Nicole Rylander Profile

Prof. Marissa Nicole Rylander

Assistant Professor at Virginia Polytechnic Institute and State Univ

SPIE Involvement:

Author

SPIE Journal Paper | 4 June 2012 Open Access

Scanning-fiber-based imaging method for tissue engineering

Matthias Hofmann, Bryce Whited, Josh Mitchell, William Vogt, Tracy Criswell, Christopher Rylander, Marissa Rylander, Shay Soker, Ge Wang, Yong Xu

JBO, Vol. 17, Issue 06, 066010, (June 2012) https://doi.org/10.1117/12.10.1117/1.JBO.17.6.066010

KEYWORDS: Luminescence, Image resolution, Skin, Imaging systems, Tissue engineering, Signal to noise ratio, Scattering, Tissues, Tissue optics, Micromirrors

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SPIE Journal Paper | 1 May 2011 Open Access

Optical properties of breast tumor phantoms containing carbon nanotubes and nanohorns

Saugata Sarkar, Christopher Rylander, Marissa Rylander, Abhijit Gurjarpadhye

JBO, Vol. 16, Issue 05, 051304, (May 2011) https://doi.org/10.1117/12.10.1117/1.3574762

KEYWORDS: Absorption, Scattering, Optical properties, Single walled carbon nanotubes, Tumors, Breast, Tissue optics, Signal attenuation, Breast cancer, Transmittance

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Proceedings Article | 21 February 2008 Paper

Effective cancer laser-therapy design through the integration of nanotechnology and computational treatment planning models

Jessica Fisher, Marissa Nichole Rylander

Proceedings Volume 6869, 68690D (2008) https://doi.org/10.1117/12.764071

KEYWORDS: Tumors, Therapeutics, Tissues, Laser therapeutics, Near infrared, Cell death, Proteins, Temperature metrology, Cancer, Laser tissue interaction

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Laser therapies can provide a minimally invasive treatment alternative to surgical resection of tumors. However, the effectiveness of these therapies is limited due to nonspecific heating of target tissue which often leads to healthy tissue injury and extended treatment durations. These therapies can be further compromised due to heat shock protein (HSP) induction in tumor regions where non-lethal temperature elevation occurs, thereby imparting enhanced tumor cell viability and resistance to subsequent chemotherapy and radiation treatments. Introducing multi-walled nanotubes (MWNT) into target tissue prior to laser irradiation increases heating selectivity permitting more precise thermal energy delivery to the tumor region and enhances thermal deposition thereby increasing tumor injury and reducing HSP expression induction. This study investigated the impact of MWNT inclusion in untreated and laser irradiated monolayer cell culture and cell phantom model. Cell viability remained high for all samples with MWNT inclusion and cells integrated into alginate phantoms, demonstrating the non-toxic nature of both MWNTs and alginate phantom models. Following, laser irradiation samples with MWNT inclusion exhibited dramatic temperature elevations and decreased cell viability compared to samples without MWNT. In the cell monolayer studies, laser irradiation of samples with MWNT inclusion experienced up-regulated HSP27, 70 and 90 expression as compared to laser only or untreated samples due to greater temperature increases albeit below the threshold for cell death. Further tuning of laser parameters will permit effective cell killing and down-regulation of HSP. Due to optimal tuning of laser parameters and inclusion of MWNT in phantom models, extensive temperature elevations and cell death occurred, demonstrating MWNT-mediated laser therapy as a viable therapy option when parameters are optimized. In conclusion, MWNT-mediated laser therapies show great promise for effective tumor destruction, but require determination of appropriate MWNT characteristics and laser parameters for maximum tumor destruction.

SPIE Journal Paper | 1 July 2006 Open Access

Optimizing heat shock protein expression induced by prostate cancer laser therapy through predictive computational models

Marissa Rylander, Yusheng Feng, Yongjie Zhang, Jon Bass, Roger Stafford, Andrei Volgin, John Hazle, Kenneth Diller

JBO, Vol. 11, Issue 04, 041113, (July 2006) https://doi.org/10.1117/12.10.1117/1.2241310

KEYWORDS: Tumors, Prostate, Data modeling, Tissues, Injuries, Proteins, Thermal modeling, Laser therapeutics, Temperature metrology, Laser tissue interaction

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Proceedings Article | 14 April 2005 Paper

Design of optimal hyperthermia protocols for prostate cancer by controlling HSP expression through computer modeling

Marissa Rylander, Yusheng Feng, Kenneth Diller, J. Bass

Proceedings Volume 5698, (2005) https://doi.org/10.1117/12.584678

KEYWORDS: Tumors, Proteins, Data modeling, Tissues, Prostate cancer, Prostate, Finite element methods, Laser tissue interaction, Thermal modeling, Laser therapeutics

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Conference Committee Involvement (10)

Optical Interactions with Tissue and Cells XXXI

1 February 2020 | San Francisco, California, United States

Optical Interactions with Tissue and Cells XXX

2 February 2019 | San Francisco, California, United States

Optical Interactions with Tissue and Cells XXIX

29 January 2018 | San Francisco, California, United States

Optical Interactions with Tissue and Cells XXVIII

30 January 2017 | San Francisco, California, United States

Optical Interactions with Tissue and Cells XXVII

14 February 2016 | San Francisco, California, United States

Showing 5 of 10 Conference Committees

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