Mr. Matt J. Van Nortwick Profile

Matt J. Van Nortwick

Graduate Student Biomedical Engineering at Univ of Michigan

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Proceedings Article | 3 March 2009 Paper

Fiber optic FTIR instrument for in vivo detection of colonic neoplasia

Matthew Van Nortwick, John Hargrove, Rolf Wolters, James Crawford, May Arroyo, Mark Mackanos, Christopher Contag, Thomas Wang

Proceedings Volume 7172, 71720K (2009) https://doi.org/10.1117/12.808570

KEYWORDS: FT-IR spectroscopy, Tissues, Optical fibers, Endoscopy, Silver, Biopsy, Absorbance, Cancer, Absorption, Endoscopes

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We demonstrate the proof of concept for use of a fiber optic FTIR instrument to perform in vivo detection of colonic neoplasia as an adjunct to medical endoscopy. FTIR is sensitive to the molecular composition of tissue, and can be used as a guide for biopsy by identifying pre-malignant tissue (dysplasia). First, we demonstrate the use of a silver halide optical fiber to collect mid-infrared absorption spectra in the 950 to 1800 cm^-1 regime with high signal-to-noise from biopsy specimens of colonic mucosa tissue ex vivo. We observed subtle differences in wavenumber and magnitude of the absorbance peaks over this regime. We then show that optimal sub-ranges can be defined within this spectral regime and that spectral pre-processing can be performed to classify the tissue as normal, hyperplasia, or dysplasia with high levels of performance. We used a partial least squares discriminant analysis and a leave-one-subject-out crossvalidation strategy to classify the spectra. The results were compared with histology, and the optimal thresholds resulted in an overall sensitivity, specificity, accuracy, and positive predictive value of 96%, 92%, 93%, and 82%, respectively for this technique. We demonstrate that mid-infrared absorption spectra can be collected remotely with an optical fiber and used to identify colonic dysplasia with high accuracy. We are now developing an endoscope compatible optical fiber to use this technique clinically for the early detection of cancer.

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