Ms. Melissa A. Lapierre-Devlin Profile

Melissa A. Lapierre-Devlin

at Boston College

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Proceedings Article | 11 November 2005 Paper

Amplified electrocatalysis at DNA-modified nanowires for ultrasensitive biosensing

Melissa Lapierre-Devlin, Shana Kelley

Proceedings Volume 6007, 600705 (2005) https://doi.org/10.1117/12.630723

KEYWORDS: Gold, Electrodes, Biosensing, 3D acquisition, Ions, Ruthenium, Diffusion, Nanostructures, Target detection, Nanowires

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Three-dimensional gold nanowire ensembles (NEE) are a novel and useful platform for electrochemical DNA detection. Work performed in our laboratory using the three-dimensional nanostructures with an electrocatalytic reporter system has produced attomole sensitivity towards target DNA sequences. Large electrocatalytic signals observed at DNA-modified nanowires produce high signal-to-noise ratios, which is one factor that contributes to the improved sensitivity. DNA- modified nanostructures generate amplified electrocatalysis signals that are significantly larger than those observed at bulk gold surfaces, and our experiments indicate that the three-dimensional architectures of the nanowires facilitate the electrocatalytic reaction because of enhanced diffusion and accessibility occurring around these structures. The heightened sensitivity achieved indicates that the nanowire ensembles constitute a promising platform for ultrasensitive biosensors.

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