Prof. Meng-Lin Li Profile

Prof. Meng-Lin Li

Associate Professor at National Tsing Hua Univ

SPIE Involvement:

Author

Publications (39)

Proceedings Article | 27 March 2023 Poster

Minimum-variance Hilbert transform based delay-multiply and sum beamforming for photoacoustic array image reconstruction

Chun-Hsien Chiang, Meng-Lin Li

Proceedings Volume PC12379, PC1237923 (2023) https://doi.org/10.1117/12.2651031

KEYWORDS: Bandpass filters, Biomedical optics, Linear filtering, Photoacoustic imaging, Image resolution, Reconstruction algorithms, Signal analyzers, Imaging arrays, Image restoration, Photoacoustic spectroscopy

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Proceedings Article | 9 March 2023 Presentation

Photoacoustic hyper-beamformation array imaging

Chun-Hsien Chiang, Meng-Lin Li

Proceedings Volume PC12379, PC123790X (2023) https://doi.org/10.1117/12.2650955

KEYWORDS: Imaging arrays, Photoacoustic spectroscopy, Photoacoustic imaging, Reconstruction algorithms, Image restoration, Image resolution, Biomedical optics, Acoustics, Absorption

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Proceedings Article | 5 March 2021 Presentation

Improving axial resolution of optical resolution photoacoustic microscopy with frequency domain delay multiply and sum beamforming method

Sing-Shuo Su, Che-Chou Shen, Meng-Lin Li

Proceedings Volume 11642, 116421E (2021) https://doi.org/10.1117/12.2582989

KEYWORDS: Optical resolution, Photoacoustic microscopy, Sensors, Imaging arrays, Ultrasonography, Spatial resolution, Signal attenuation, Photoacoustic spectroscopy, Photoacoustic imaging, In vivo imaging

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Proceedings Article | 6 March 2020 Presentation

Low complexity and flexible baseband delay-multiply-and-sum photoacoustic array imaging (Conference Presentation)

Meng-Lin Li, Che-Chou Shen

Proceedings Volume 11240, 112402K (2020) https://doi.org/10.1117/12.2546990

KEYWORDS: Imaging arrays, Photoacoustic spectroscopy, Photoacoustic imaging, Image quality, Multispectral imaging, Signal to noise ratio, Image resolution, Bandpass filters, Image filtering, Linear filtering

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Proceedings Article | 6 March 2020 Presentation

In vivo cuticle intact Drosophila mushroom body imaging using laser scanning optical resolution photoacoustic microscopy (Conference Presentation)

Kai-Yao Chang, Wen-Hung Shih, Shun-Chi Wu, Kwok Ho Lam, Yen-Yin Lin, Ann-Shyn Chiang, Meng-Lin Li

Proceedings Volume 11240, 112401Z (2020) https://doi.org/10.1117/12.2547187

KEYWORDS: In vivo imaging, Laser scanners, Optical resolution, Photoacoustic microscopy, Brain, Whole body imaging, Surgery, Neuroimaging, Calcium, Animal model studies

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Proceedings Article | 4 March 2019 Presentation

Improved light delivery in biological tissue using HIFU heating tunnel: photoacoustic verification (Conference Presentation)

Zong Han Hsieh, Chih-Kuang Yeh, Meng-Lin Li

Proceedings Volume 10878, 108782P (2019) https://doi.org/10.1117/12.2507771

KEYWORDS: Photoacoustic spectroscopy, Tissue optics, Light scattering, Monte Carlo methods, Scattering, Optical imaging, Biomedical optics, Photon transport, Ultrasonography, Thermal effects

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Proceedings Article | 4 March 2019 Presentation

Real-time swept-beam compact photoacoustic/ultrasound imaging system (Conference Presentation)

Geng-Shi Jeng, Soon Joon Yoon, Ivan Pelivanov, Meng-Lin Li, Liang Gao, David Li, Matthew O'Donnell

Proceedings Volume 10878, 1087827 (2019) https://doi.org/10.1117/12.2509330

KEYWORDS: Imaging systems, In vivo imaging, Multispectral imaging, Photoacoustic spectroscopy, Photoacoustic imaging, Wavelength tuning, Fiber optics, System integration, Transducers, Light sources

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Proceedings Article | 4 March 2019 Presentation

In vivo three dimensional cuticle intact Drosophila brain imaging using laser scanning optical resolution photoacoustic microscopy

Kai-Yao Chang, Hsuan Ou-Yang, Pei-Shan Ho, Shun-Chi Wu, Yen-Yin Lin, Ann-Shyn Chiang, Meng-Lin Li

Proceedings Volume 10878, 108781Y (2019) https://doi.org/10.1117/12.2508091

KEYWORDS: Surgery, Confocal microscopy, Photoacoustic microscopy, Optical resolution, Laser scanners, Brain imaging, 3D photoacoustic microscopy, 3D image processing, In vivo imaging, Brain

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Proceedings Article | 3 March 2014 Paper

NIR-activated iron oxides as a new multi-functional contrast agent of photoacoustic imaging

Pei-Hsien Ting, Chih-Chia Huang, Meng-Lin Li

Proceedings Volume 8943, 89434E (2014) https://doi.org/10.1117/12.2037448

KEYWORDS: Pulsed laser operation, Imaging systems, Photoacoustic imaging, Photoacoustic spectroscopy, Near infrared, Oxides, Iron, Magnetism, Absorption, Nanoparticles

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Proceedings Article | 3 March 2014 Paper

Optical resolution photoacoustic microscopy using a Blu-ray DVD pickup head

Meng-Lin Li, Po-Hsun Wang

Proceedings Volume 8943, 894315 (2014) https://doi.org/10.1117/12.2037146

KEYWORDS: Digital video discs, Head, Blood, Photoacoustic spectroscopy, Optical resolution, Photoacoustic microscopy, Transducers, Ear, Absorption, Ultrasonography

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Optical resolution photoacoustic microscopy (OR-PAM) has been shown as a promising tool for label-free microvascular and single-cell imaging in clinical and bioscientific applications. However, most OR-PAM systems are realized by using a bulky laser for photoacoustic excitation. The large volume and high price of the laser may restrain the popularity of OR-PAM. In this study, we attempt to develop a compact, portable, and low cost OR-PAM based on a consumer Blu-ray (405 nm) DVD pickup head for label-free micro-vascular imaging and red-blood-cell related blood examination. According to the high optical absorption of the hemoglobin at 405 nm, the proposed OR-PAM has potential to be an alternative for the conventional optical microscopy in the examinations of hematological morphology for blood routine. We showed that the Blu-ray DVD pickup head owns the required laser energy and focusing optics for OR-PAM. The firmware of a Blu-ray DVD drive was modified to allow its pickup head to generate nano-second laser pulses with a tunable pulse repetition rate of >30 kHz and a tunable pulse width ranging from 10 to 30 ns. The laser beam was focused onto the target after passing through a transparent cover slide, and then aligned to be confocal with a 50-MHz focused ultrasonic transducer in forward mode. To keep the target on focus, a scan involving auto-tracking procedure was performed. The measured maximum achievable lateral resolution was 1 μm which was mainly limited by the minimum step size of the used motorized stage. A blood smear was imaged without any staining. The red blood cells were well resolved and the biconcave structure could be clearly visualized. In addition, to verify the in vivo imaging capability of the proposed OR-PAM, the micro-vasculature of a mouse ear was imaged without any contrast agent. The results showed that it performed better than a 200x digital optical microscope in terms of image contrast and vascular morphology. In summaries, the proposed OR-PAM has been demonstrated as a promising tool for label-free blood imaging in both small animal studies and blood examinations, and potentially can be a compact and low-cost OR-PAM platform.

Proceedings Article | 3 March 2014 Paper

Image reconstruction of photoacoustic tomography based on finite-aperture-effect corrected compressed sensing algorithm

Chien-Hao Chiu, Yen Chuo, Meng-Lin Li

Proceedings Volume 8943, 89433X (2014) https://doi.org/10.1117/12.2037149

KEYWORDS: Transducers, Acquisition tracking and pointing, Reconstruction algorithms, Signal detection, Data acquisition, Ultrasonography, Image restoration, Compressed sensing, Photoacoustic tomography, Data modeling

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SPIE Journal Paper | 3 June 2013 Open Access

Deep-penetration photoacoustic array imaging of calcifications

Tsai-Chu Hsiao, Yao-Yu Cheng, Wan-Ting Tein, Shih-Bin Luo, De-Yi Chiou, Ren-Jei Chung, Meng-Lin Li

JBO, Vol. 18, Issue 06, 066002, (June 2013) https://doi.org/10.1117/12.10.1117/1.JBO.18.6.066002

KEYWORDS: Breast, Imaging arrays, Particles, Ultrasonography, Blood, Visualization, Imaging systems, Photoacoustic imaging, Photoacoustic spectroscopy, Signal attenuation

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Proceedings Article | 4 March 2013 Paper

Functional photoacoustic micro-imaging of cerebral hemodynamic changes in single blood vessels after photo-induced brain stroke

Lun-De Liao, You-Yin Chen, Chin-Teng Lin, Meng-Lin Li

Proceedings Volume 8581, 858133 (2013) https://doi.org/10.1117/12.2003543

KEYWORDS: Blood vessels, Hemodynamics, Brain, In vivo imaging, Ischemic stroke, Ultrasonics, Electrodes, Transducers, Photoacoustic microscopy, Blood

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SPIE Journal Paper | 7 May 2012 Open Access

Gold-nanorod contrast-enhanced photoacoustic micro-imaging of focused-ultrasound induced blood-brain-barrier opening in a rat model

Po-Hsun Wang, Meng-Lin Li, Hao-Li Liu, Po-Hung Hsu, Chia-Yu Lin, Chung-Ren Wang, Pin-Yuan Chen, Kuo-Chen Wei, Tzu-Chen Yen

JBO, Vol. 17, Issue 6, 061222, (May 2012) https://doi.org/10.1117/12.10.1117/1.JBO.17.6.061222

KEYWORDS: Blood brain barrier, Brain, Photoacoustic spectroscopy, Absorption, Blood, Neuroimaging, Magnetic resonance imaging, Animal model studies, Gold, Ultrasonography

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SPIE Journal Paper | 7 May 2012 Open Access

Investigation of the cerebral hemodynamic response function in single blood vessels by functional photoacoustic microscopy

Lun-De Liao, Chin-Teng Lin, Hsin-Yi Lai, Jyh-Yeong Chang, You-Yin Chen, Yen-Yu Shih, Timothy Duong, Wan-Ting Zhao, Meng-Lin Li

JBO, Vol. 17, Issue 6, 061210, (May 2012) https://doi.org/10.1117/12.10.1117/1.JBO.17.6.061210

KEYWORDS: Blood vessels, Hemodynamics, Blood, Photoacoustic microscopy, Brain, Functional magnetic resonance imaging, Transducers, Signal detection, Neuroimaging, Ultrasonics

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Proceedings Article | 23 February 2012 Paper

Photoacoustic array imaging of calcifications: phantom study

Yao-You Cheng, Tsai-Chu Hsiao, Wan-Ting Tien, Shih-Bin Luo, De-Yi Chiou, Meng-Lin Li

Proceedings Volume 8223, 822335 (2012) https://doi.org/10.1117/12.908206

KEYWORDS: Ultrasonography, Imaging systems, Imaging arrays, Particles, Photoacoustic spectroscopy, Breast, Tissue optics, Breast cancer, Transducers, Image resolution

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Proceedings Article | 23 February 2012 Paper

Functional photoacoustic micro-imaging of rat cerebral hemodynamic response function in single vessels during forepaw electrical stimulation

Lun-De Liao, You-Yin Chen, Chin-Teng Lin, Jyh-Yeong Chang, Meng-Lin Li

Proceedings Volume 8223, 822334 (2012) https://doi.org/10.1117/12.908131

KEYWORDS: Hemodynamics, Blood vessels, Ultrasonics, Transducers, Photoacoustic spectroscopy, Photoacoustic microscopy, Blood, In vivo imaging, Oxygen, Spatial resolution

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Proceedings Article | 23 February 2012 Paper

DVD pickup head based optical resolution photoacoustic microscopy

Po-Hsun Wang, Meng-Lin Li

Proceedings Volume 8223, 82232V (2012) https://doi.org/10.1117/12.907680

KEYWORDS: Digital video discs, Head, Photoacoustic spectroscopy, Photoacoustic microscopy, Adaptive optics, Carbon, Optical resolution, Image resolution, Ultrasonography, Transducers

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Proceedings Article | 19 February 2011 Paper

Functional transcranial photoacoustic micro-imaging of mouse cerebrovascular cross-section and hemoglobin oxygenation changes during forepaw electrical stimulation

Lun-De Liao, You-Yin Chen, Chin-Teng Lin, Jyh-Yeong Chang, Meng-Lin Li

Proceedings Volume 7899, 78992X (2011) https://doi.org/10.1117/12.874449

KEYWORDS: Ultrasonics, Absorption, Skull, Transducers, Hemodynamics, Photoacoustic spectroscopy, In vivo imaging, Ultrasonography, Signal to noise ratio, Somatosensory cortex

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Proceedings Article | 19 February 2011 Paper

Visualization of microcalcifications using photoacoustic imaging: feasibility study

Tsai-Chu Hsiao, Po-Hsun Wang, Chih-Tai Fan, Yao-You Cheng, Meng-Lin Li

Proceedings Volume 7899, 78992U (2011) https://doi.org/10.1117/12.874335

KEYWORDS: Breast, Photoacoustic imaging, Blood, Particles, Breast cancer, Imaging systems, Mammography, Ultrasonography, Near infrared, Photoacoustic spectroscopy

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Proceedings Article | 26 February 2010 Paper

Photoacoustic microscopy of collagenase-induced Achilles tendinitis in a mouse model

Po-Hsun Wang, Wen-Shiang Chen, Meng-Lin Li

Proceedings Volume 7564, 75642Q (2010) https://doi.org/10.1117/12.841565

KEYWORDS: Ultrasonics, Photoacoustic spectroscopy, Ultrasonography, Photoacoustic microscopy, Inflammation, Photoacoustic imaging, Mouse models, Injuries, Blood vessels, Transducers

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Proceedings Article | 24 February 2010 Paper

Photoacoustic micro-imaging of focused ultrasound induced blood-brain-barrier opening in a rat model

Po-Hsun Wang, Po-Hung Hsu, Hao-Li Liu, Churng-Ren Chris Wang, Meng-Lin Li

Proceedings Volume 7564, 75642U (2010) https://doi.org/10.1117/12.841811

KEYWORDS: Blood brain barrier, Brain, Ultrasonography, Absorption, Photoacoustic spectroscopy, In vivo imaging, Neuroimaging, Tissue optics, Photoacoustic microscopy, Tissues

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Proceedings Article | 24 February 2010 Paper

In vivo functional photoacoustic micro-imaging of the electrically stimulated rat brain with multiwavelengths

Lun-De Liao, Meng-Lin Li, Hsin-Yi Lai, You-Yin Chen, Paul C.-P. Chao, Po-Hsun Wang

Proceedings Volume 7564, 75643F (2010) https://doi.org/10.1117/12.843085

KEYWORDS: Brain, Neuroimaging, In vivo imaging, Tissue optics, Photoacoustic spectroscopy, Photoacoustic microscopy, Ultrasonography, Biomedical optics, Signal detection, Somatosensory cortex

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Proceedings Article | 24 February 2010 Paper

Reconstruction of photoacoustic tomography with finite-aperture detectors: deconvolution of the spatial impulse response

Meng-Lin Li, Chung-Chih Cheng

Proceedings Volume 7564, 75642S (2010) https://doi.org/10.1117/12.841639

KEYWORDS: Transducers, Acquisition tracking and pointing, Image resolution, Photoacoustic tomography, Reconstruction algorithms, Sensors, Photoacoustic spectroscopy, Signal detection, Deconvolution, Spatial resolution

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SPIE Journal Paper | 1 January 2009 Open Access

In-vivo photoacoustic microscopy of nanoshell extravasation from solid tumor vasculature

Meng-Lin Li, James Wang, Jon Schwartz, Kelly Gill-Sharp, George Stoica, Lihong Wang

JBO, Vol. 14, Issue 01, 010507, (January 2009) https://doi.org/10.1117/12.10.1117/1.3081556

KEYWORDS: Tumors, Photoacoustic spectroscopy, Absorption, In vivo imaging, Solids, Gold, Photoacoustic microscopy, Transducers, Blood, Image resolution

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Proceedings Article | 28 February 2008 Paper

Adaptive photoacoustic imaging using the Mallart-Fink focusing factor

Meng-Lin Li

Proceedings Volume 6856, 685627 (2008) https://doi.org/10.1117/12.764317

KEYWORDS: Photoacoustic imaging, Signal to noise ratio, Near field, Photoacoustic spectroscopy, Tissues, Breast, Tissue optics, Image resolution, Ultrasonography, Transducers

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Proceedings Article | 28 February 2007 Paper

In-vivo imaging of nanoshell extravasation from solid tumor vasculature by photoacoustic microscopy

Meng-Lin Li, Jon Schwartz, James Wang, George Stoica, Lihong Wang

Proceedings Volume 6437, 64370B (2007) https://doi.org/10.1117/12.697722

KEYWORDS: Tumors, Gold, In vivo imaging, Solids, Laser sources, Blood, Absorption, Photoacoustic microscopy, Tissue optics, Transducers

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Proceedings Article | 13 February 2007 Paper

A study of reconstruction in photoacoustic tomography with a focused transducer

Meng-Lin Li, Lihong Wang

Proceedings Volume 6437, 64371E (2007) https://doi.org/10.1117/12.703716

KEYWORDS: Transducers, Acquisition tracking and pointing, Sensors, Photoacoustic tomography, Image resolution, Photoacoustic spectroscopy, Reconstruction algorithms, Point spread functions, Algorithm development, Breast

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Proceedings Article | 13 February 2007 Paper

Imaging microvascular dynamics noninvasively with realtime photoacoustic microscopy

Roger Zemp, Rachel Bitton, Meng-Lin Li, K. Kirk Shung, Lihong Wang

Proceedings Volume 6430, 643015 (2007) https://doi.org/10.1117/12.700484

KEYWORDS: Visualization, Photoacoustic microscopy, Photoacoustic spectroscopy, Ultrasonography, Data acquisition, Oscilloscopes, Blood, Transducers, Pulsed laser operation, Spatial resolution

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Proceedings Article | 13 February 2007 Paper

Photoacoustic tomography with a virtual point detector

Xinmai Yang, Meng-Lin Li, Lihong Wang

Proceedings Volume 6437, 643718 (2007) https://doi.org/10.1117/12.698367

KEYWORDS: Sensors, Signal detection, Signal to noise ratio, Spatial resolution, Photoacoustic tomography, Photoacoustic spectroscopy, Image resolution, Acquisition tracking and pointing, Image restoration, Signal processing

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SPIE Journal Paper | 1 January 2007 Open Access

Photoacoustic imaging of the microvasculature with a high-frequency ultrasound array transducer

Roger Zemp, Rachel Bitton, K. Shung, Meng-Lin Li, George Stoica, Lihong Wang

JBO, Vol. 12, Issue 01, 010501, (January 2007) https://doi.org/10.1117/12.10.1117/1.2709850

KEYWORDS: Ultrasonography, Photoacoustic imaging, Transducers, Skin, Photoacoustic microscopy, Data acquisition, Optical fibers, Imaging systems, Visualization, Photography

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SPIE Journal Paper | 1 May 2006 Open Access

Three-dimensional imaging of skin melanoma in vivo by dual-wavelength photoacoustic microscopy

Jung-Taek Oh, Meng-Lin Li, Hao Zhang, Konstantin Maslov, Lihong Wang

JBO, Vol. 11, Issue 03, 034032, (May 2006) https://doi.org/10.1117/12.10.1117/1.2210907

KEYWORDS: Melanoma, Skin, Photoacoustic spectroscopy, 3D image processing, Absorption, In vivo imaging, Tissue optics, Visible radiation, Near infrared, 3D photoacoustic microscopy

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