Prof. Michael F. Insana Profile

Prof. Michael F. Insana

Professor

SPIE Involvement:

Author

Publications (41)

Proceedings Article | 1 April 2024 Presentation + Paper

Improving image quality in a new method of data-driven elastography

Will Newman, Jamshid Ghaboussi, Michael Insana

Proceedings Volume 12932, 129320B (2024) https://doi.org/10.1117/12.3004814

KEYWORDS: Finite element methods, Machine learning, Artificial neural networks, Materials properties, Matrices, Data modeling, Ultrasonography, Physics, Elastography

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Quasi-static ultrasonic elasticity imaging (QUSE) lacks necessary data to solve inverse 3-D elasticity problems mathematically. The autoprogressive method (AutoP) is a recently developed, data-driven approach to QUSE that leverages finite element physics and machine learning techniques primed for sensing complex relationships with limited data. The process involves propagating measured force and displacement data from ultrasound into stress-strain training data through finite element analysis (FEA) to train artificial neural networks (ANNs) to learn both constitutive behavior and spatial heterogeneity. Internal displacement data provides material information about the entire 3-D contiguous volume that is integrated into the learning process through FEA physics. To use FEA for tissues as a solid, we must assume they are somewhat compressible to avoid numeric instability, however this assumption introduces a bias into the training data that impacts the quality of the learned material properties. The trade-off between bias and numeric instability must be resolved to provide the highest quality training data to the networks. To understand this trade-off, force and displacement data were acquired from quasi-static compression of an incompressible, linear-elastic gelatin phantom with a stiff cylindrical inclusion. AutoP tests were performed using simulated and measured displacement data sets. For each data set, ANNs were initialized with stress-strain data from simulated compression of a uniform material with a Poisson’s ratio of 0.30, 0.40, and 0.45. We found improvement in the resulting Young’s modulus distribution using a Poisson’s ratio of 0.4 over 0.3, however using 0.45 resulted in non-physical behavior. We have developed an approach that balances numeric instability with training data bias and considers additional complications of sampling and meshing decisions to generate high-quality material property images. Discerning these trade-offs for linear-elastic materials is essential for the extension into multi-phasic, non-linear and time-dependent material property imaging with AutoP.

Proceedings Article | 4 April 2022 Presentation + Paper

Registration methods in power Doppler ultrasound for peripheral perfusion imaging

Bingze Dai, Somaye Babaei, Craig Abbey, Michael Insana

Proceedings Volume 12038, 120380F (2022) https://doi.org/10.1117/12.2612640

KEYWORDS: Blood, Principal component analysis, Tissues, Doppler effect, Image registration, Image filtering, Transducers, Motion estimation, Electronic filtering, Error analysis

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Proceedings Article | 15 February 2021 Presentation + Paper

Clutter filtering strategies for peripheral muscle perfusion imaging using ultrasound

Michael Insana, Yang Zhu, Somaye Babaei, Denise Medina Almora, L. Wawrzyniec Dobrucki, Craig Abbey

Proceedings Volume 11602, 116020M (2021) https://doi.org/10.1117/12.2580871

KEYWORDS: Ultrasonography, Independent component analysis, Image filtering, Principal component analysis, Tissues, Ischemia, Doppler effect, Transducers, Standards development, Scattering

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Proceedings Article | 10 September 2019 Open Access

Exploiting data sparsity to enhance sensitivity in medical images (Conference Presentation)

Michael Insana

Proceedings Volume 11136, 1113602 (2019) https://doi.org/10.1117/12.2525407

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Proceedings Article | 13 March 2017 Paper

Imaging spatially varying biomechanical properties with neural networks

Cameron Hoerig, Wendy Reyes, Léo Fabre, Jamshid Ghaboussi, Michael Insana

Proceedings Volume 10139, 1013905 (2017) https://doi.org/10.1117/12.2254331

KEYWORDS: Elastography, Tissues, Machine learning, Finite element methods, Ultrasonography, Inverse problems, Mathematical modeling, Artificial neural networks, 3D modeling, Kidney, Data modeling, Image segmentation, Neural networks

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Proceedings Article | 1 April 2016 Paper

Ultrasound perfusion signal processing for tumor detection

MinWoo Kim, Craig Abbey, Michael Insana

Proceedings Volume 9790, 97900O (2016) https://doi.org/10.1117/12.2214345

KEYWORDS: Ultrasonography, Blood, Tissues, Statistical analysis, Principal component analysis, Signal processing, Doppler effect, Ultrasonics, Blood circulation, Sensor performance, Data modeling, Tumors, Analytical research

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Proceedings Article | 1 April 2016 Paper

A new approach to ultrasonic elasticity imaging

Cameron Hoerig, Jamshid Ghaboussi, Mostafa Fatemi, Michael Insana

Proceedings Volume 9790, 97900G (2016) https://doi.org/10.1117/12.2216549

KEYWORDS: Tissues, Ultrasonography, Ultrasonics, Diagnostics, Inverse problems, Data modeling, Medical imaging, Machine learning, Finite element methods, Neural networks, 3D modeling, Image segmentation, Data acquisition

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Proceedings Article | 19 March 2014 Paper

Analyzing the performance of ultrasonic B-mode imaging for breast lesion diagnosis

Sara Bahramian, Craig Abbey, Michael Insana

Proceedings Volume 9033, 90332A (2014) https://doi.org/10.1117/12.2043944

KEYWORDS: Signal to noise ratio, Ultrasonography, Image processing, Imaging systems, Data acquisition, Breast, Scattering, Signal analyzers, Ultrasonics, Data modeling

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Proceedings Article | 11 March 2014 Paper

Retrieving high spatial frequency information in sonography for improved microcalcification detection

Sara Bahramian, Michael Insana

Proceedings Volume 9037, 90370W (2014) https://doi.org/10.1117/12.2043955

KEYWORDS: Image processing, Spatial frequencies, Data acquisition, Signal processing, Breast, Scattering, Image acquisition, Signal detection, Ultrasonography, Ultrasonics

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Proceedings Article | 25 February 2012 Paper

Frequency, bandwidth, and information transfer in B-mode imaging

Craig Abbey, Nghia Nguyen, Michael Insana

Proceedings Volume 8320, 83200I (2012) https://doi.org/10.1117/12.912430

KEYWORDS: Filtering (signal processing), Signal processing, Signal analyzers, Signal attenuation, Image processing, Signal to noise ratio, Reflectivity, Ultrasonography, Detection theory, Diffraction

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Proceedings Article | 12 March 2010 Paper

Tomographic reconstruction of the pulse-echo spatiotemporal impulse response

Nghia Nguyen, Craig Abbey, Rebecca Yapp, Michael Insana

Proceedings Volume 7629, 76290F (2010) https://doi.org/10.1117/12.845736

KEYWORDS: Transducers, Data modeling, Ultrasonography, Image filtering, Tomography, Data acquisition, Radon, 3D modeling, Point spread functions, 3D displays

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Proceedings Article | 13 March 2009 Paper

Ultrasonic array beamforming with iterative spatial filters

Nghia Nguyen, Craig Abbey, Michael Insana

Proceedings Volume 7265, 72650A (2009) https://doi.org/10.1117/12.813456

KEYWORDS: Image segmentation, Filtering (signal processing), Data conversion, Data modeling, Image filtering, Scattering, Visualization, Spatial filters, Point spread functions, Signal processing

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Proceedings Article | 13 March 2009 Open Access

Statistical ultrasonics: the influence of Robert F. Wagner

Michael Insana

Proceedings Volume 7263, 72630E (2009) https://doi.org/10.1117/12.817798

KEYWORDS: Ultrasonics, Imaging systems, Statistical analysis, Speckle, Tissues, Medical imaging, Scattering, Signal to noise ratio, Visualization, Image processing

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Proceedings Article | 10 March 2008 Paper

An ideal observer approach to beamforming

Craig Abbey, Nghia Nguyen, Michael Insana

Proceedings Volume 6920, 692006 (2008) https://doi.org/10.1117/12.772776

KEYWORDS: Point spread functions, Signal processing, Scattering, Laser scattering, Diagnostics, Phased arrays, Matrices, Ultrasonography, Systems modeling, Transform theory

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Proceedings Article | 15 February 2008 Paper

Modeling and measurement of tissue elastic moduli using optical coherence elastography

Xing Liang, Amy Oldenburg, Vasilica Crecea, Sureshkumar Kalyanam, Michael Insana, Stephen Boppart

Proceedings Volume 6858, 685803 (2008) https://doi.org/10.1117/12.760779

KEYWORDS: Tissues, Tissue optics, Elastography, Optical coherence tomography, Silicon, Coherence (optics), Tumors, Soft tissue optics, Breast, 3D modeling

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Proceedings Article | 10 May 2007 Paper

Molecular and structural analysis of viscoelastic properties

Rebecca Yapp, Sureshkumar Kalyanam, Michael Insana

Proceedings Volume 6511, 65111Y (2007) https://doi.org/10.1117/12.708723

KEYWORDS: Data modeling, Finite element methods, Polymers, Breast, Tissues, Collagen, Ultrasonography, Molecules, Image processing, Structural analysis

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Proceedings Article | 20 March 2007 Paper

A bivariate binormal ROC methodology for comparing new methods to an existing standard for screening applications

Craig Abbey, Michael Insana, Miguel Eckstein, John Boone

Proceedings Volume 6515, 651505 (2007) https://doi.org/10.1117/12.711513

KEYWORDS: Mammography, Statistical analysis, Diagnostics, Data modeling, Standards development, Breast cancer, Imaging technologies, Tumor growth modeling, Monte Carlo methods, Biopsy

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Proceedings Article | 12 March 2007 Paper

Ultrasonic radiation forces for elasticity imaging of 3-D tissue models

M. Orescanin, M. Insana

Proceedings Volume 6513, 65130H (2007) https://doi.org/10.1117/12.710644

KEYWORDS: Optical spheres, Doppler effect, Acoustics, Transducers, Cameras, Calibration, Polymers, Video, Ultrasonics, 3D modeling

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Proceedings Article | 17 March 2006 Paper

Observer efficiency in boundary discrimination tasks related to assessment of breast lesions with ultrasound

Craig Abbey, Roger Zemp, Jie Liu, Karen Lindfors, Michael Insana

Proceedings Volume 6146, 61460O (2006) https://doi.org/10.1117/12.655731

KEYWORDS: Image filtering, Electronic filtering, Image processing, Scattering, Ultrasonography, Diagnostics, Filtering (signal processing), Breast, Matrices, Image acquisition

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Proceedings Article | 16 March 2006 Paper

Efficient array beamformer using spatial filtering for ultrasound B-mode imaging

Kang-Sik Kim, Jie Liu, Michael Insana

Proceedings Volume 6147, 61470C (2006) https://doi.org/10.1117/12.652474

KEYWORDS: Single mode fibers, Spatial filters, Phased arrays, Point spread functions, Imaging arrays, Near field, Ultrasonography, Beam analyzers, Optical simulations, Electronic filtering

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Proceedings Article | 12 April 2005 Paper

Vascular wall shear rate measurement using coded excitation techniques

Jean Tsou, Jie Liu, Michael Insana

Proceedings Volume 5750, (2005) https://doi.org/10.1117/12.596100

KEYWORDS: Phase modulation, Fermium, Frequency modulation, Blood, Spatial resolution, Error analysis, Transducers, Ultrasonography, Doppler effect, Signal to noise ratio

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Proceedings Article | 28 April 2004 Paper

Simultaneous narrowband ultrasonic strain-flow imaging

Jean Tsou, Jerome Mai, Fermin Lupotti, Michael Insana

Proceedings Volume 5373, (2004) https://doi.org/10.1117/12.536802

KEYWORDS: Tissues, Arteries, Blood, Doppler effect, Ultrasonography, Blood circulation, Imaging systems, Data acquisition, In vivo imaging, Filtering (signal processing)

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Proceedings Article | 28 April 2004 Paper

Ultrasonic mechanical relaxation imaging of pH in biopolymers

Mallika Sridhar, Huini Du, Claire Pellot-Barakat, Scott Simon, Michael Insana

Proceedings Volume 5373, (2004) https://doi.org/10.1117/12.536975

KEYWORDS: Polymers, Tissues, Tumors, Signal to noise ratio, Ultrasonography, Collagen, Data modeling, Ultrasonics, Visualization, Biopolymers

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Proceedings Article | 5 June 2003 Paper

Generalized NEQ for assessment of ultrasound image quality

Roger Zemp, Craig Abbey, Michael Insana

Proceedings Volume 5030, (2003) https://doi.org/10.1117/12.480134

KEYWORDS: Signal to noise ratio, Ultrasonography, Signal detection, Imaging systems, Image quality, Modulation transfer functions, Systems modeling, Target detection, Fourier transforms, Point spread functions

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Proceedings Article | 23 May 2003 Paper

Digital filter design for strain-flow imaging

Christian Kargel, Gernot Hobenreich, Michael Insana

Proceedings Volume 5035, (2003) https://doi.org/10.1117/12.479914

KEYWORDS: Tissues, Optical filters, Image filtering, Doppler effect, Electronic filtering, Infinite impulse response filters, Blood, Data acquisition, Digital filtering, Transducers

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Proceedings Article | 22 May 2003 Paper

Pre-envelope deconvolution for increased lesion detection efficiency in ultrasonic imaging

Craig Abbey, Roger Zemp, Michael Insana

Proceedings Volume 5034, (2003) https://doi.org/10.1117/12.480099

KEYWORDS: Deconvolution, Ultrasonography, Signal detection, Scattering, Data modeling, Systems modeling, Transducers, Image processing, Demodulation, Convolution

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Proceedings Article | 9 May 2002 Paper

Accelerating ultrasonic strain reconstructions by introducing mechanical constraints

Claire Pellot-Barakat, Jerome Mai, Christian Kargel, Alain Herment, Birget Trummer, Michael Insana

Proceedings Volume 4684, (2002) https://doi.org/10.1117/12.467173

KEYWORDS: Tissues, Breast, Data acquisition, Reconstruction algorithms, Arteries, Ultrasonics, Image compression, In vivo imaging, Error analysis, Spatial resolution

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Proceedings Article | 11 April 2002 Paper

Ultrasonic annular array system for detecting tissue motion

Hisham Mhanna, Birget Trummer, Christian Kargel, Michael Insana

Proceedings Volume 4687, (2002) https://doi.org/10.1117/12.462152

KEYWORDS: Transducers, Tissues, Spatial resolution, Tumors, Signal to noise ratio, Optical simulations, Ultrasonics, Ultrasonography, Optical filters, Signal processing

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Proceedings Article | 30 May 2001 Paper

Standing wave pressure fields generated in an acoustic levitation chamber

Andrew Hancock, John Allen, Dustin Kruse, Paul Dayton, Christian Kargel, Michael Insana

Proceedings Volume 4325, (2001) https://doi.org/10.1117/12.428233

KEYWORDS: Particles, Acoustics, Transducers, Reflection, Photography, Lithium niobate, Solids, Adhesives, Biomedical engineering, Measurement devices

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Proceedings Article | 30 May 2001 Paper

Optimization of real-time high-frequency ultrasound for blood flow imaging in the microcirculation

Dustin Kruse, Jerome Mai, Ronald Silverman, Michael Insana, D. Coleman, Katherine Ferrara

Proceedings Volume 4325, (2001) https://doi.org/10.1117/12.428203

KEYWORDS: Blood circulation, Tissues, Velocity measurements, Ultrasonography, Transducers, Optical filters, Blood, Filtering (signal processing), Electronic filtering, Signal attenuation

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Proceedings Article | 30 May 2001 Paper

Ultrasonic strain imaging in media with pulsatile flow

Jerome Mai, Christian Kargel, Hisham Mhanna, Michael Insana

Proceedings Volume 4325, (2001) https://doi.org/10.1117/12.428190

KEYWORDS: Tissues, Ultrasonography, Ultrasonics, Data acquisition, Image compression, Image processing, Blood, Velocity measurements, Acoustics, Signal attenuation

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Proceedings Article | 12 April 2000 Paper

Bioelasticity imaging:II. Spatial resolution

Larry Cook, Yanning Zhu, Timothy Hall, Michael Insana

Proceedings Volume 3982, (2000) https://doi.org/10.1117/12.382240

KEYWORDS: Ultrasonography, Modulation transfer functions, Spatial resolution, Point spread functions, Ultrasonics, Tissues, Spatial frequencies, Optical spheres, Imaging systems, Modulation

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Proceedings Article | 12 April 2000 Paper

Utility of quantitative ultrasound for tracking the progression of polycystic kidney disease

Timothy Hall, Htet Khant, Michael Insana, John Wood, Yanning Zhu, David Preston, Benjamin Cowley

Proceedings Volume 3982, (2000) https://doi.org/10.1117/12.382221

KEYWORDS: Kidney, Ultrasonography, Tissues, Backscatter, Ultrasonics, Acoustics, Blood, Imaging systems, In vitro testing, Control systems

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Proceedings Article | 12 April 2000 Paper

Comparing the performance of ultrasonic strain imaging algorithms

Yanning Zhu, Timothy Hall, Larry Cook, Michael Insana

Proceedings Volume 3982, (2000) https://doi.org/10.1117/12.382238

KEYWORDS: Modulation transfer functions, Kidney, Spatial frequencies, Spatial resolution, Imaging systems, Ultrasonics, Ultrasonography, Tissues, Detection and tracking algorithms, Motion models

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Proceedings Article | 28 May 1999 Paper

Bioelasticity imaging: system design

Michael Insana, Larry Cook

Proceedings Volume 3659, (1999) https://doi.org/10.1117/12.349497

KEYWORDS: Imaging systems, Ultrasonics, Ultrasonography, Tissues, Spatial resolution, Modulation transfer functions, Ions, Motion models, Tantalum, Point spread functions

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Proceedings Article | 16 April 1996 Paper

Comparison of spectral estimation methods in reconstruction of parametric ultrasound images

Pawan Chaturvedi, Michael Insana, Timothy Hall

Proceedings Volume 2710, (1996) https://doi.org/10.1117/12.237966

KEYWORDS: Autoregressive models, Signal to noise ratio, Tissues, Biological research, Ultrasonography, Interference (communication), Image quality, Data modeling, Image resolution, Fourier transforms

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Proceedings Article | 27 March 1996 Paper

Contrast-detail analysis of the effect of image compression on computed tomographic images

Larry Cook, Glendon Cox, Michael Insana, Michael McFadden, Timothy Hall, Roger Gaborski, Fleming Lure

Proceedings Volume 2712, (1996) https://doi.org/10.1117/12.236849

KEYWORDS: Image compression, Head, Computed tomography, Skull, Wavelets, Detection and tracking algorithms, Tomography, Radiology, Wave propagation, Image analysis

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Proceedings Article | 17 April 1995 Paper

Further investigation into the effects of lossy compression using free-response methodology

Larry Cook, Michael Insana, Michael McFadden, Timothy Hall, Glendon Cox, Kyle Bryans

Proceedings Volume 2436, (1995) https://doi.org/10.1117/12.206853

KEYWORDS: Image compression, Signal to noise ratio, Chest, Computer simulations, Radiology, Radiography, Quantization, Diagnostics, Receivers, Bone

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Proceedings Article | 1 April 1994 Paper

Assessment of low-contrast detectability for compressed digital chest images

Larry Cook, Michael Insana, Michael McFadden, Timothy Hall, Glendon Cox

Proceedings Volume 2166, (1994) https://doi.org/10.1117/12.171737

KEYWORDS: Image compression, Chromium, Chest, Target detection, Chest imaging, Critical dimension metrology, Signal to noise ratio, Visualization, Absorbance, Data modeling

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Proceedings Article | 1 July 1990 Paper

Application of statistical pattern recognition and image processing in ultrasound tissue characterization

Reza Momenan, Murray Loew, Robert Wagner, Brian Garra, Michael Insana

Proceedings Volume 1233, (1990) https://doi.org/10.1117/12.18906

KEYWORDS: Image processing, Ultrasonography, Tissues, Image segmentation, Image processing algorithms and systems, Liver, Kidney, Medical imaging, Tumors, Visualization

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Proceedings Article | 1 July 1990 Paper

Application of parametric spectral estimation to medical ultrasound and magnetic resonance spectroscopy

Keith Wear, Robert Wagner, Brian Garra, Laurence Grossman, Michael Insana, Kyle Myers, Sunder Rajan

Proceedings Volume 1231, (1990) https://doi.org/10.1117/12.18781

KEYWORDS: Autoregressive models, Ultrasonography, Magnetic resonance imaging, Data modeling, Ultrasonics, Magnetism, Spectroscopy, Tissues, Chemical analysis, Imaging systems

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