While CBCT provides excellent guidance capability, it is less adept at localizing soft tissue targets growing in a low image contrast environment. To advance image-guided irradiation for soft tissue targets, we developed quantitative bioluminescence tomography(QBLT) for small animal radiation research platform(SARRP). We presented a comprehensive approach to systematically tackle the challenging of BLT for in vivo target delineation, quantify its uncertainties in localization, and demonstrate the practicality for radiation guidance. Our QBLT-guided system provides a unique opportunity for investigators to guide conformal irradiation for soft tissue targets. The accurate image-guidance is expected to increase rigorous and reproducibility of scientific discovery.
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