Dr. Michael B. Sinclair Profile

Dr. Michael B. Sinclair

at Sandia National Labs

SPIE Involvement:

Author

Publications (23)

Proceedings Article | 4 October 2023 Presentation

Near-field imaging of optical resonance modes in silicon metasurfaces using photoelectron microscopy

Alex Boehm, Sylvain Gennaro, Chloe Doiron, Thomas Beechem, Michael Sinclair, Igal Brener, Raktim Sarma, Taisuke Ohta

Proceedings Volume PC12646, PC1264616 (2023) https://doi.org/10.1117/12.2676035

KEYWORDS: Near field optics, Near field, Silicon, Electron microscopy, Optical imaging, Quantum nanophotonics, Quantum fields, Light-matter interactions, Imaging spectroscopy, Resonators

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Proceedings Article | 9 September 2019 Presentation

High-harmonic generation from an epsilon-near-zero material (Conference Presentation)

Yuanmu Yang, Jian Lu, Alejandro Manjavacas, Ting Shan Luk, Hanzhe Liu, Kyle Kelley, Jon-Paul Maria, Michael Sinclair, Evan Runnerstrom, Shambhu Ghimire, Igal Brener

Proceedings Volume 11080, 110800D (2019) https://doi.org/10.1117/12.2537655

KEYWORDS: Solid state physics, Extreme ultraviolet, Light sources, Ultraviolet radiation, Chemical species, Solids, Absorption, Cadmium, Oxides, Nanophotonics

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Proceedings Article | 19 September 2018 Paper

Coupling effects in dense arrays of 3D optical metamaterials

D. Bruce Burckel, Bryan Adomanis, Salvatore Campione, Michael Sinclair

Proceedings Volume 10719, 107190L (2018) https://doi.org/10.1117/12.2322185

KEYWORDS: Polarization, Magnetism, Split ring resonators, Scattering, Optical arrays, Optical metamaterials, Silicon, Data modeling, 3D modeling, Finite-difference time-domain method

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Proceedings Article | 17 September 2018 Presentation

Voltage tuning of reflectance from a strongly coupled metasurface-semiconductor hybrid structure (Conference Presentation)

Raktim Sarma, Salvatore Campione, Michael Goldflam, Joshua Shank, Sean Smith, Jinhyun Noh, Peide Ye, Michael Sinclair, Ganapathi Subramania, Isaac Ruiz, Stephen Howell, Joel Wendt, Igal Brener

Proceedings Volume 10721, 107211E (2018) https://doi.org/10.1117/12.2321256

KEYWORDS: Reflectivity, Modulation, Beam steering, Dielectric polarization, Electronics, Semiconductors, Gold, Indium gallium arsenide, Doping, Scattering

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Proceedings Article | 17 September 2018 Presentation

Reflectance modulation from a metasurface coupled to intersubband transitions in semiconductor quantum wells using quantum tunneling (Conference Presentation)

Raktim Sarma, Salvatore Campione, Michael Goldflam, Loan Le, M. Lange, Joshua Shank, Michael Wanke, Jinhyun Noh, Peide Ye, Isaac Ruiz, Stephen Howell, Michael Sinclair, Joel Wendt, Igal Brener

Proceedings Volume 10721, 1072123 (2018) https://doi.org/10.1117/12.2321900

KEYWORDS: Quantum wells, Modulation, Reflectivity, Semiconductors, Indium gallium arsenide, Heterojunctions, Optical design, Ultrafast phenomena, Optical modulators, Tunable filters

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Proceedings Article | 10 September 2011 Paper

Modeling study of multi-layer 3D metamaterials

D. Bruce Burckel, Michael Sinclair

Proceedings Volume 8093, 809317 (2011) https://doi.org/10.1117/12.893718

KEYWORDS: Resonators, Metamaterials, Magnetism, 3D modeling, Electromagnetism, Polarization, Split ring resonators, Solids, Projection lithography, Multilayers

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Proceedings Article | 9 September 2010 Paper

Micro-optics for high-efficiency optical performance and simplified tracking for concentrated photovoltaics (CPV)

W. Sweatt, B. Jared, G. Nielson, M. Okandan, A. Filatov, M. Sinclair, J. Cruz-Campa, A. Lentine

Proceedings Volume 7652, 765210 (2010) https://doi.org/10.1117/12.870964

KEYWORDS: Solar cells, Photovoltaics, Lenses, Collimation, Micro optics, Sun, Absorption, Lens design, Silicon, Energy efficiency

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Proceedings Article | 22 August 2009 Paper

Metamaterial resonators on curved surfaces

D. B. Burckel, P. Davids, I. Brener, G. Ten Eyck, A. R. Ellis, J. Wendt, B. Passmore, E. Shaner, M. Sinclair

Proceedings Volume 7392, 739204 (2009) https://doi.org/10.1117/12.826903

KEYWORDS: Resonators, Metamaterials, Magnetism, Lithography, Scanning electron microscopy, 3D modeling, Spherical lenses, Metals, Finite-difference time-domain method, Microwave radiation

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Proceedings Article | 4 March 2009 Paper

Hyperspectral image correlation for monitoring membrane protein dynamics in living cells

Ryan Davis, Bryan Carson, Howland D. Jones, Michael Sinclair

Proceedings Volume 7184, 71840J (2009) https://doi.org/10.1117/12.807743

KEYWORDS: Luminescence, Diffusion, Receptors, Imaging spectroscopy, Optical filters, Image analysis, Hyperspectral imaging, Image processing, Proteins, Image filtering

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Temporal image correlation provides a powerful fluorescence technique for measuring several biologically relevant parameters of molecules in living cells. These parameters include, but are not limited to local concentrations, diffusion dynamics, and aggregation states of biomolecules. However, the complex cellular environment presents several limitations, precluding high quantitative accuracy and constraining biological implementation. In order to address these issues, high speed spectral imaging was employed to compare the results of image correlation from spectrally unmixed and virtually implemented fluorescence emission filters. Of particular interest in this study is the impact of cellular autofluorescence, which is ubiquitous in fluorescence imaging of cells and tissues. Using traditional instrumentation, corrections for autofluorescence are commonly estimated as a static offset collected from a separate control specimen. While this may be sufficient in highly homogenous regions of interest, the low analyte concentrations requisite to fluctuation-based methods result in the potential for unbounded error resulting from spectral cross-talk between local autofluorescence inhomogeneities and the fluorescence signal of interest. Thus we demonstrate the importance of accurate autofluorescence characterization and discuss potential corrections using a case study focusing on fluorescence confocal spectral imaging of immune cells before and after stimulation with lipopolysaccheride (LPS). In these experiments, binding of LPS to the membrane receptor, YFP-TLR4, is observed to result in initiation of the immune response characterized by altered receptor diffusion dynamics and apparent heterogeneous aggregation states. In addition to characterizing errors resulting from autofluorescence spectral bleed-through, we present data leading to a deeper understanding of the molecular dynamics of the immune response and suggest hypotheses for future work utilizing hyperspectrally enabled multi-label fluorescence studies on this system of high biological import.

Proceedings Article | 29 August 2008 Paper

Variable-angle directional emissometer for moderate-temperature emissivity measurements

A. R. Ellis, H. M. Graham, Michael Sinclair, J. C. Verley

Proceedings Volume 7065, 706508 (2008) https://doi.org/10.1117/12.796507

KEYWORDS: Reflectivity, Temperature metrology, Sensors, FT-IR spectroscopy, High dynamic range imaging, Mirrors, Reflectometry, Signal detection, Aluminum, Data modeling

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Proceedings Article | 28 February 2008 Paper

Accurate measurement of cellular autofluorescence is critical for imaging of host-pathogen interactions

Jerilyn Timlin, Rachel Noek, Julia Kaiser, Michael Sinclair, Howland Jones, Ryan Davis, Todd Lane

Proceedings Volume 6859, 68590A (2008) https://doi.org/10.1117/12.763915

KEYWORDS: Imaging spectroscopy, Proteins, Luminescence, Fluorescent proteins, Bacteria, Microscopes, Signal detection, Tissues, Confocal microscopy, Image analysis

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Proceedings Article | 15 October 2007 Paper

Hyperspectral confocal fluorescence imaging of cells

David Haaland, Howland Jones, Michael Sinclair, Bryan Carson, Catherine Branda, Jens Poschet, Roberto Rebeil, Bing Tian, Ping Liu, Allan Brasier

Proceedings Volume 6765, 676509 (2007) https://doi.org/10.1117/12.738152

KEYWORDS: Microscopes, Luminescence, Green fluorescent protein, Hyperspectral imaging, Confocal microscopy, Composites, Imaging systems, Proteins, Image analysis, Live cell imaging

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Confocal fluorescence imaging of biological systems is an important method by which researchers can investigate molecular processes occurring in live cells. We have developed a new 3D hyperspectral confocal fluorescence microscope that can further enhance the usefulness of fluorescence microscopy in studying biological systems. The new microscope can increase the information content obtained from the image since, at each voxel, the microscope records 512 wavelengths from the emission spectrum (490 to 800 nm) while providing optical sectioning of samples with diffraction-limited spatial resolution. When coupled with multivariate curve resolution (MCR) analyses, the microscope can resolve multiple spatially and spectrally overlapped emission components, thereby greatly increasing the number of fluorescent labels, relative to most commercial microscopes, that can be monitored simultaneously. The MCR algorithm allows the "discovery" of all emitting sources and estimation of their relative concentrations without cross talk, including those emission sources that might not have been expected in the imaged cells. In this work, we have used the new microscope to obtain time-resolved hyperspectral images of cellular processes. We have quantitatively monitored the translocation of the GFP-labeled RelA protein (without interference from autofluorescence) into and out of the nucleus of live HeLa cells in response to continuous stimulation by the cytokine, TNFα. These studies have been extended to imaging live mouse macrophage cells with YFP-labeled RelA and GFP-labeled IRF3 protein. Hyperspectral imaging coupled with MCR analysis makes possible, for the first time, quantitative analysis of GFP, YFP, and autofluorescence without concern for cross-talk between emission sources. The significant power and quantitative capabilities of the new hyperspectral imaging system are further demonstrated with the imaging of a simple fluorescence dye (SYTO 13) traditionally used to stain the nucleus of live cells. We will demonstrate the microscope system's ability to actually discover and quantify the presence of two separate SYTO 13 fluorescent species shifted in wavelength by only a few nm. These two emission components exhibit very different spatial distributions in macrophage cells (i.e., nucleus vs. cytoplasm + nucleus). Two highly overlapped autofluorescence components in addition to the two SYTO 13 components were also observed, and the spatial distributions of the two autofluorescence components were quantitatively mapped throughout the cells in three dimensions.

Proceedings Article | 27 February 2007 Paper

Exploring membrane protein dynamics by multicolor single quantum dot imaging using wide field, TIRF, and hyperspectral microscopy

Diane Lidke, Nicholas Andrews, Janet Pfeiffer, Howland D.T. Jones, Michael Sinclair, David Haaland, Alan Burns, Bridget Wilson, Janet Oliver, Keith Lidke

Proceedings Volume 6448, 64480Y (2007) https://doi.org/10.1117/12.718464

KEYWORDS: Proteins, Microscopes, Microscopy, Hyperspectral imaging, Diffusion, Receptors, Imaging systems, Quantum dots, Luminescence, Particles

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Proceedings Article | 21 February 2006 Paper

Imaging multiple endogenous and exogenous fluorescent species in cells and tissues

Jerilyn Timlin, Linda Nieman, Howland Jones, Michael Sinclair, David Haaland, John Guzowski

Proceedings Volume 6088, 608805 (2006) https://doi.org/10.1117/12.647228

KEYWORDS: Tissues, Hyperspectral imaging, Microscopes, Glasses, Luminescence, Image analysis, Brain, Biological research, Neuroimaging, Optical filters

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Proceedings Article | 23 January 2006 Paper

Microstereolithography production of integrated Hadamard mask structures

Christopher Robinson, Larinn Southwell, Jeremy Palmer, Mark Smith, Michael Sinclair, Bart Chavez, Brent Stucker, Francisco Medina, Ryan Wicker

Proceedings Volume 6109, 61090B (2006) https://doi.org/10.1117/12.646417

KEYWORDS: Photomasks, Computer aided design, Spectroscopy, Prototyping, Manufacturing, Integrated optics, Microfabrication, Solids, Optical mounts, Solid modeling

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Proceedings Article | 24 January 2004 Paper

A MEMS-based correlation radiometer

Michael Sinclair, Kent Pfeifer, Michael Butler, Stephen Senturia, Erik Deutsch, Dan Youngner, Eugen Cabuz, G. Hocker

Proceedings Volume 5346, (2004) https://doi.org/10.1117/12.536306

KEYWORDS: Radiometry, Modulation, Sensors, Diffraction gratings, Mirrors, Radio optics, Electrodes, Prototyping, Infrared radiation, Signal detection

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Proceedings Article | 2 July 2003 Paper

Multivariate curve resolution for hyperspectral image analysis: applications to microarray technology

David Haaland, Jerilyn Timlin, Michael Sinclair, Mark Van Benthem, M. Juanita Martinez, Anthony Aragon, Margaret Werner-Washburne

Proceedings Volume 4959, (2003) https://doi.org/10.1117/12.477945

KEYWORDS: Scanners, Glasses, Axons, Hyperspectral imaging, Luminescence, Image analysis, Fluorescent markers, Image resolution, Optical filters, Laser scanners

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Proceedings Article | 13 November 2001 Paper

A plethora of micro-optical systems

William Sweatt, Mial Warren, Shanalyn Kemme, Todd Christenson, Olga Blum-Spahn, Michael Sinclair, Michael Butler, Stephen Gentry

Proceedings Volume 4437, (2001) https://doi.org/10.1117/12.448149

KEYWORDS: Molecules, Absorption, Fiber optics, Telecommunications, X-ray lithography, X-rays, Lithography, Sensors, Vertical cavity surface emitting lasers, Fiber optic communications

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Proceedings Article | 3 May 1999 Paper

Thin-film silica sol-gels doped with ion-responsive fluorescent lipid bilayers

Darryl Sasaki, Lauren Shea, Michael Sinclair

Proceedings Volume 3602, (1999) https://doi.org/10.1117/12.347531

KEYWORDS: Metals, Ions, Silica, Luminescence, Sol-gels, Thin films, Sensors, Time multiplexed optical shutter, Receptors, Fiber optics

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Proceedings Article | 31 October 1997 Paper

Synthetic infrared spectra for correlation spectroscopy

Michael Sinclair, Michael Butler, Antonio Ricco, Stanley Kravitz, W. Zubrzycki, Mial Warren

Proceedings Volume 3118, (1997) https://doi.org/10.1117/12.292690

KEYWORDS: Chemical elements, Modulation, Spectroscopy, Spectrometers, Diffraction, Infrared radiation, Infrared spectroscopy, Etching, Holography, Absorption

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Proceedings Article | 15 May 1997 Paper

Diffractive optical elements for the production of synthetic spectra

Michael Sinclair, Michael Butler, Antonio Ricco, Stanley Kravitz, W. Zubrzycki

Proceedings Volume 3010, (1997) https://doi.org/10.1117/12.274400

KEYWORDS: Spectroscopy, Chemical elements, Modulation, Infrared radiation, Diffraction, Sensors, Etching, Absorption, Diffractive optical elements, Holography

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Proceedings Article | 19 June 1995 Paper

Fractal quantum well heterostructures for broadband light emitters

Mary Crawford, Paul Gourley, Ken Meissner, Michael Sinclair, Eric Jones, Weng Chow, Richard Schneider

Proceedings Volume 2399, (1995) https://doi.org/10.1117/12.212516

KEYWORDS: Fractal analysis, Luminescence, Quantum wells, Heterojunctions, Light emitting diodes, Visible radiation, Gallium arsenide, Electrons, Time metrology, Temperature metrology

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Proceedings Article | 25 February 1993 Paper

Dielectric optical waveguide sensors integrated with GaAs active devices

Richard Carson, Stephen Casalnuovo, Michael Sinclair

Proceedings Volume 1791, (1993) https://doi.org/10.1117/12.141159

KEYWORDS: Waveguides, Sensors, Light emitting diodes, Refractive index, Dielectrics, Gallium arsenide, Photodetectors, Silicon, Reliability, Etching

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Showing 5 of 23 publications

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