Phenology monitoring observations have been traditionally linked to citizen science (CS) practices and limited to common species closely located to an observer’s residence. This is a modest approximation to cover the strong variability of the vegetation phenology across biomes and to improve the knowledge of vegetation changes as climate change impacts. Thankfully, remote sensing imagery (RS), especially data from high spatial and temporal resolution satellites such as Sentinel-2A and 2B, has the potential to become an essential dataset for in-situ approaches by guiding volunteers in achieving this aim. This study presents the methodological design carried out in Catalunya to harmonize phenological vegetation monitoring protocol between RS and CS making data acquired from both approaches interoperable. First, an Earth Observation Open Data Cube (ODC) containing Sentinel-2 radiometrically corrected data was created. The ODC offers a solution for storing big data products in an efficient way with low-cost hardware and provides easy access to data by indexing it. A selection of ~40 000 areas presenting a homogeneous cover common species of interest has been extracted from existing vegetation cartography. A time-series analysis of vegetation indices (greening and flowering) derived from the ODC has been performed for each area. A final subset of ~5 000 areas presenting a flowering amplitude signal > 10% and a greening-up amplitude signal > 20% was extracted and included in an interactive map browser available to CS observers so they are guided to interesting areas to report their phenophase and evaluate their correlation with RS data. This protocol, resulting from the PhenoTandem project (CSEOL - ESA) provides an innovative approach making in-situ observations interoperable with RS products and confirms a promising partnership for phenology monitoring.